Efficacy and Comparative Effectiveness of Atypical Antipsychotic Medications for Off-Label Uses in Adults: A Systematic Review and Meta-Analysis

2013 ◽  
Vol 2013 ◽  
pp. 348-349
Author(s):  
P.F. Buckley
Keyword(s):  
Systematic Review ◽  
Atypical Antipsychotic ◽  
Comparative Effectiveness ◽  
Meta Analysis ◽  
Antipsychotic Medications ◽  
Off Label ◽  
Atypical Antipsychotic Medications

scholarly journals Efficacy and Comparative Effectiveness of Atypical Antipsychotic Medications for Off-Label Uses in Adults

JAMA ◽  
2011 ◽  
Vol 306 (12) ◽  
pp. 1359 ◽  
Author(s):  
Alicia Ruelaz Maher ◽  
Margaret Maglione ◽  
Steven Bagley ◽  
Marika Suttorp ◽  
Jian-Hui Hu ◽  
...  
Keyword(s):  
Atypical Antipsychotic ◽  
Comparative Effectiveness ◽  
Antipsychotic Medications ◽  
Off Label ◽  
Atypical Antipsychotic Medications

Risk of Death with Atypical Antipsychotic Medications for Dementia

2018 ◽  
Author(s):  
Adam P. Mecca ◽  
Rajesh R. Tampi
Keyword(s):  
Side Effects ◽  
Atypical Antipsychotic ◽  
Odds Ratio ◽  
Clinical Case ◽  
Atypical Antipsychotics ◽  
Meta Analysis ◽  
Antipsychotic Medications ◽  
Risk Of Death ◽  
Increased Risk ◽  
Atypical Antipsychotic Medications

This chapter provides a summary of a landmark meta-analysis that investigated the risks of atypical antipsychotic use to treat psychosis, aggression, or agitation in patients with dementia. The chapter briefly reviews the study design, as well as implications and limitations. A relevant clinical case concludes the chapter. In summary, atypical antipsychotic use for 6 to 26 weeks was associated with increased risk of death (Odds Ratio of 1.54 for antipsychotic vs placebo). There were no differences in risk between individual medications, disease severity, indication for antipsychotic, or treatment setting. In patients with psychosis, agitation, or aggression due to dementia, the efficacy of atypical antipsychotics is questionable and their use comes with considerable risks of side effects and adverse events.

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