scholarly journals Subthalamic Nucleus Stimulation Increases Brain Derived Neurotrophic Factor in the Nigrostriatal System and Primary Motor Cortex

2011 ◽  
Vol 1 (1) ◽  
pp. 123-136 ◽  
Author(s):  
Anne L. Spieles-Engemann ◽  
Kathy Steece-Collier ◽  
Michael M. Behbehani ◽  
Timothy J. Collier ◽  
Susan L. Wohlgenant ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Subthalamic Nucleus ◽  
Neurotrophic Factor ◽  
Primary Motor Cortex ◽  
Brain Derived Neurotrophic Factor ◽  
Nigrostriatal System ◽  
Subthalamic Nucleus Stimulation

scholarly journals Do Brain-Derived Neurotrophic Factor Genetic Polymorphisms Modulate the Efficacy of Motor Cortex Plasticity Induced by Non-invasive Brain Stimulation? A Systematic Review

2021 ◽  
Vol 15 ◽  
Author(s):  
Ryoki Sasaki ◽  
Sho Kojima ◽  
Hideaki Onishi
Keyword(s):  
Systematic Review ◽  
Motor Cortex ◽  
Brain Stimulation ◽  
Neural Plasticity ◽  
Neurotrophic Factor ◽  
Primary Motor Cortex ◽  
Motor Evoked Potential ◽  
Brain Derived Neurotrophic Factor ◽  
Motor Deficit ◽  
Non Invasive

Techniques of non-invasive brain stimulation (NIBS) of the human primary motor cortex (M1) are widely used in basic and clinical research to induce neural plasticity. The induction of neural plasticity in the M1 may improve motor performance ability in healthy individuals and patients with motor deficit caused by brain disorders. However, several recent studies revealed that various NIBS techniques yield high interindividual variability in the response, and that the brain-derived neurotrophic factor (BDNF) genotype (i.e., Val/Val and Met carrier types) may be a factor contributing to this variability. Here, we conducted a systematic review of all published studies that investigated the effects of the BDNF genotype on various forms of NIBS techniques applied to the human M1. The motor-evoked potential (MEP) amplitudes elicited by single-pulse transcranial magnetic stimulation (TMS), which can evaluate M1 excitability, were investigated as the main outcome. A total of 1,827 articles were identified, of which 17 (facilitatory NIBS protocol, 27 data) and 10 (inhibitory NIBS protocol, 14 data) were included in this review. More than two-thirds of the data (70.4–78.6%) on both NIBS protocols did not show a significant genotype effect of NIBS on MEP changes. Conversely, most of the remaining data revealed that the Val/Val type is likely to yield a greater MEP response after NIBS than the Met carrier type in both NIBS protocols (21.4–25.9%). Finally, to aid future investigation, we discuss the potential effect of the BDNF genotype based on mechanisms and methodological issues.

scholarly journals Modulation of motor cortex neuronal activity and motor behavior during subthalamic nucleus stimulation in the normal primate

2015 ◽  
Vol 113 (7) ◽  
pp. 2549-2554 ◽  
Author(s):  
Luke A. Johnson ◽  
Weidong Xu ◽  
Kenneth B. Baker ◽  
Jianyu Zhang ◽  
Jerrold L. Vitek
Keyword(s):  
Motor Cortex ◽  
Subthalamic Nucleus ◽  
Neuronal Activity ◽  
Stimulus Intensity ◽  
Motor Performance ◽  
Primary Motor Cortex ◽  
Motor Behavior ◽  
Retrieval Task ◽  
Subthalamic Nucleus Stimulation ◽  
Stn Dbs

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established surgical therapy for advanced Parkinson's disease (PD). An emerging hypothesis is that the therapeutic benefit of DBS is derived from direct modulation of primary motor cortex (M1), yet little is known about the influence of STN DBS on individual neurons in M1. We investigated the effect of STN DBS, delivered at discrete interval intensities (20, 40, 60, 80, and 100%) of corticospinal tract threshold (CSTT), on motor performance and M1 neuronal activity in a naive nonhuman primate. Motor performance during a food reach and retrieval task improved during low-intensity stimulation (20% CSTT) but worsened as intensity approached the threshold for activation of corticospinal fibers (80% and 100% CSTT). To assess cortical effects of STN DBS, spontaneous, extracellular neuronal activity was collected from M1 neurons before, during, and after DBS at the same CSTT stimulus intensities. STN DBS significantly modulated the firing of a majority of M1 neurons; however, the direction of effect varied with stimulus intensity such that, at 20% CSTT, most neurons were suppressed, whereas at the highest stimulus intensities the majority of neurons were activated. At a population level, firing rates increased as stimulus intensity increased. These results show that STN DBS influences both motor performance and M1 neuronal activity systematically according to stimulus intensity. In addition, the unanticipated reduction in reach times suggests that STN DBS, at stimulus intensities lower than typically used for treatment of PD motor signs, can enhance normal motor performance.

Somatotopically arranged inputs from putamen and subthalamic nucleus to primary motor cortex

2006 ◽  
Vol 56 (3) ◽  
pp. 300-308 ◽  
Author(s):  
Shigehiro Miyachi ◽  
Xiaofeng Lu ◽  
Michiko Imanishi ◽  
Kaori Sawada ◽  
Atsushi Nambu ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Subthalamic Nucleus ◽  
Primary Motor Cortex

scholarly journals Brain-Derived Neurotrophic Factor – A Major Player in Stimulation-Induced Homeostatic Metaplasticity of Human Motor Cortex?

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e57957 ◽  
Author(s):  
Claudia Mastroeni ◽  
Til Ole Bergmann ◽  
Vincenzo Rizzo ◽  
Christoph Ritter ◽  
Christine Klein ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Human Motor Cortex ◽  
Major Player ◽  
Human Motor

Effects of subthalamic nucleus stimulation on motor cortex excitability in Parkinson's disease

Neurology ◽  
2002 ◽  
Vol 58 (11) ◽  
pp. 1665-1672 ◽  
Author(s):  
D. Cunic ◽  
L. Roshan ◽  
F. I. Khan ◽  
A. M. Lozano ◽  
A. E. Lang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Subthalamic Nucleus ◽  
Subthalamic Nucleus Stimulation ◽  
Motor Cortex Excitability
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