scholarly journals Effect of Low versus High Frequency Subthalamic Deep Brain Stimulation on Speech Intelligibility and Verbal Fluency in Parkinson’s Disease: A Double-Blind Study

2019 ◽  
Vol 9 (1) ◽  
pp. 141-151 ◽  
Author(s):  
Timothy Grover ◽  
Dejan Georgiev ◽  
Rania Kalliola ◽  
Philipp Mahlknecht ◽  
André Zacharia ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
High Frequency ◽  
Verbal Fluency ◽  
Speech Intelligibility ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Deep Brain

scholarly journals Deep Brain Stimulation Frequency of the Subthalamic Nucleus Affects Phonemic and Action Fluency in Parkinson’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Valéria de Carvalho Fagundes ◽  
Carlos R. M. Rieder ◽  
Aline Nunes da Cruz ◽  
Bárbara Costa Beber ◽  
Mirna Wetters Portuguez
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
High Frequency ◽  
Verbal Fluency ◽  
Low Frequency ◽  
Stn Dbs ◽  
Deep Brain

Introduction.Deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson’s disease (PD) has been linked to a decline in verbal fluency. The decline can be attributed to surgical effects, but the relative contributions of the stimulation parameters are not well understood. This study aimed to investigate the impact of the frequency of STN-DBS on the performance of verbal fluency tasks in patients with PD.Methods.Twenty individuals with PD who received bilateral STN-DBS were evaluated. Their performances of verbal fluency tasks (semantic, phonemic, action, and unconstrained fluencies) upon receiving low-frequency (60 Hz) and high-frequency (130 Hz) STN-DBS were assessed.Results.The performances of phonemic and action fluencies were significantly different between low- and high-frequency STN-DBS. Patients showed a decrease in these verbal fluencies for high-frequency STN-DBS.Conclusion.Low-frequency STN-DBS may be less harmful to the verbal fluency of PD patients.

Seizure outcome after hippocampal deep brain stimulation in patients with refractory temporal lobe epilepsy: A prospective, controlled, randomized, double-blind study

Epilepsia ◽  
2017 ◽  
Vol 58 (10) ◽  
pp. 1728-1733 ◽  
Author(s):  
Arthur Cukiert ◽  
Cristine Mella Cukiert ◽  
Jose Augusto Burattini ◽  
Pedro Paulo Mariani ◽  
Daniela Fontes Bezerra
Keyword(s):  
Deep Brain Stimulation ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Brain Stimulation ◽  
Blind Study ◽  
Seizure Outcome ◽  
Double Blind Study ◽  
Double Blind ◽  
Deep Brain

A double-blind study on a patient with tardive dyskinesia treated with pallidal deep brain stimulation

2009 ◽  
Vol 119 (4) ◽  
pp. 269-273 ◽  
Author(s):  
Z. Kefalopoulou ◽  
A. Paschali ◽  
E. Markaki ◽  
P. Vassilakos ◽  
J. Ellul ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Tardive Dyskinesia ◽  
Brain Stimulation ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

scholarly journals Intraoperative Characterization of Subthalamic Nucleus-to-Cortex Evoked Potentials in Parkinson’s Disease Deep Brain Stimulation

2021 ◽  
Vol 15 ◽  
Author(s):  
Lila H. Levinson ◽  
David J. Caldwell ◽  
Jeneva A. Cronin ◽  
Brady Houston ◽  
Steve I. Perlmutter ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Evoked Potentials ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
High Frequency ◽  
Therapeutic Effects ◽  
Stn Dbs ◽  
Deep Brain

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a clinically effective tool for treating medically refractory Parkinson’s disease (PD), but its neural mechanisms remain debated. Previous work has demonstrated that STN DBS results in evoked potentials (EPs) in the primary motor cortex (M1), suggesting that modulation of cortical physiology may be involved in its therapeutic effects. Due to technical challenges presented by high-amplitude DBS artifacts, these EPs are often measured in response to low-frequency stimulation, which is generally ineffective at PD symptom management. This study aims to characterize STN-to-cortex EPs seen during clinically relevant high-frequency STN DBS for PD. Intraoperatively, we applied STN DBS to 6 PD patients while recording electrocorticography (ECoG) from an electrode strip over the ipsilateral central sulcus. Using recently published techniques, we removed large stimulation artifacts to enable quantification of STN-to-cortex EPs. Two cortical EPs were observed – one synchronized with DBS onset and persisting during ongoing stimulation, and one immediately following DBS offset, here termed the “start” and the “end” EPs respectively. The start EP is, to our knowledge, the first long-latency cortical EP reported during ongoing high-frequency DBS. The start and end EPs differ in magnitude (p < 0.05) and latency (p < 0.001), and the end, but not the start, EP magnitude has a significant relationship (p < 0.001, adjusted for random effects of subject) to ongoing high gamma (80–150 Hz) power during the EP. These contrasts may suggest mechanistic or circuit differences in EP production during the two time periods. This represents a potential framework for relating DBS clinical efficacy to the effects of a variety of stimulation parameters on EPs.

High-frequency deep brain stimulation of the putamen improves bradykinesia in Parkinson's disease

2011 ◽  
Vol 27 (1) ◽  
pp. 168-169
Author(s):  
Erwin B. Montgomery ◽  
He Huang ◽  
Harrison C. Walker ◽  
Barton L. Guthrie ◽  
Ray L. Watts
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
High Frequency ◽  
Deep Brain ◽  
Stimulation Of
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