scholarly journals Quality of Life and Mild Cognitive Impairment in Early Parkinson’s Disease: Does Subtype Matter?

2015 ◽  
Vol 4 (3) ◽  
pp. 331-336 ◽  
Author(s):  
Rachael A. Lawson ◽  
Alison J. Yarnall ◽  
Gordon W. Duncan ◽  
Tien K. Khoo ◽  
David P. Breen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Parkinson’S Disease

scholarly journals Severity of mild cognitive impairment in early Parkinson's disease contributes to poorer quality of life

2014 ◽  
Vol 20 (10) ◽  
pp. 1071-1075 ◽  
Author(s):  
Rachael A. Lawson ◽  
Alison J. Yarnall ◽  
Gordon W. Duncan ◽  
Tien K. Khoo ◽  
David P. Breen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Parkinson’S Disease

Impact of Mild Cognitive Impairment on Health-Related Quality of Life in Parkinson's Disease

2013 ◽  
Vol 36 (1-2) ◽  
pp. 67-75 ◽  
Author(s):  
William Reginold ◽  
Sarah Duff-Canning ◽  
Christopher Meaney ◽  
Melissa J. Armstrong ◽  
Susan Fox ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals P.155 Prospective cohort analysis of normal versus mild cognitive impairment for quality of life outcome following DBS for Parkinson’s disease

2021 ◽  
Vol 48 (s3) ◽  
pp. S64-S64
Author(s):  
C Honey ◽  
T Almeida ◽  
CR Honey
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prospective Cohort ◽  
Linear Regression Analysis ◽  
Cohort Analysis ◽  
Normal Cognition

Background: All guidelines for DBS in Parkinson’s disease (PD) include a contraindication for ‘dementia’. It is unclear where this cut-off should occur and if patients with mild cognitive impairment (MCI) do not do as well. This prospective cohort analysis assessed if pre-operative cognition affected post-operative quality of life. Methods: PD patients receiving bilateral STN-DBS (n=100) were prospectively studied using STROBE guidelines. All had Montreal Cognitive Assessment (MoCA), motor (UPDRS), mood (BDI-II), and quality of life (Parkinson Disease Questionnaire summary index, PDQ-39-SI). Two cohorts, pre-operative MCI (MoCA:18-25) and normal cognition (MoCA:26-30), had post-operative PDQ-39-SI at 1-year. The primary outcome was the proportion of patients with an improved PDQ-39-SI at 1-year. Results: Cohorts were not significantly different in age, severity of illness, response to dopamine, or mood. MCI was present in 27/100. Improved quality of life at 1-year occurred in 75% with normal cognition and 70% with MCI (p=0.54) with RR=1.1 (95% CI, 0.8-1.5). Linear regression analysis showed no correlation between pre-operative cognition and post-operative outcome (R2=0.02). Conclusions: Parkinson’s patients with MCI should be offered DBS if their motor symptoms require surgery. Guidelines for DBS surgery in PD should change from “dementia is contraindicated” to “patients require adequate cognitive functioning, MoCA318”.

Mild cognitive impairment in Parkinson's disease: Characterization and impact on quality of life according to subtype

2019 ◽  
Vol 19 (6) ◽  
pp. 497-502 ◽  
Author(s):  
Luiz Felipe R Vasconcellos ◽  
João S Pereira ◽  
Helenice Charchat‐Fichman ◽  
Denise Greca ◽  
Manuela Cruz ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment

Lower serum uric acid is associated with mild cognitive impairment in early Parkinson’s disease: a 4-year follow-up study

2016 ◽  
Vol 123 (12) ◽  
pp. 1399-1402 ◽  
Author(s):  
Maria Teresa Pellecchia ◽  
Riccardo Savastano ◽  
Marcello Moccia ◽  
Marina Picillo ◽  
Pietro Siano ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Uric Acid ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Serum Uric Acid ◽  
Lower Serum ◽  
Follow Up Study ◽  
Early Parkinson’S Disease

Effects of Simulated Horseback Riding on Balance, Postural Sway, and Quality of Life in Older Adults With Parkinson’s Disease

2019 ◽  
Vol 36 (4) ◽  
pp. 413-430 ◽  
Author(s):  
Leah S. Goudy ◽  
Brandon Rhett Rigby ◽  
Lisa Silliman-French ◽  
Kevin A. Becker
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Postural Sway ◽  
Berg Balance Scale ◽  
Horseback Riding ◽  
Scale Scores

The purpose of this study was to determine changes in balance, postural sway, and quality of life after 6 wk of simulated horseback riding in adults diagnosed with Parkinson’s disease. Eight older adults completed two 60-min riding sessions weekly for 6 wk. Variables of balance, postural sway, and quality of life were measured 6 wks before and within 1 wk before and after the intervention. Berg Balance Scale scores decreased from baseline to preintervention (48.36 ± 5.97 vs. 45.86 ± 6.42,p = .050) and increased from preintervention to postintervention (45.86 ± 6.42 vs. 50.00 ± 4.38,p = .002). Cognitive impairment, a dimension of quality of life, improved from baseline to postintervention (37.5 ± 20.5 vs. 21.5 ± 14.4,p = .007). Six weeks of simulated horseback riding may improve balance and cognitive impairment in older adults with Parkinson’s disease.

Rasagiline improves quality of life in patients with early Parkinson's disease

2006 ◽  
Vol 21 (5) ◽  
pp. 616-623 ◽  
Author(s):  
Kevin M. Biglan ◽  
Steven Schwid ◽  
Shirley Eberly ◽  
Karen Blindauer ◽  
Stanley Fahn ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Early Parkinson’S Disease

IMPACT & TREATMENT OF NON-MOTOR SYMPTOMS IN EARLY PARKINSON'S DISEASE

2015 ◽  
Vol 86 (11) ◽  
pp. e4.80-e4
Author(s):  
Fahd Baig ◽  
Michael Lawton ◽  
Michal Rolinski ◽  
Claudio Ruffmann ◽  
Kannan Nithi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Symptoms ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Non Motor Symptoms ◽  
Early Parkinson’S Disease

ObjectiveTo delineate treatment and quality of life of non-motor symptoms (NMS) in early Parkinson's disease (PD) and first-degree relatives.BackgroundNon-motor symptoms (NMS) are an important prodromal feature of Parkinson's disease (PD). However, their frequency, treatment rates and impact on health-related quality of life (HRQoL) in the early motor phase is unclear.Methods769 population-ascertained PD subjects within 3.5 years of diagnosis and 287 control subjects were assessed. Validated severity questionnaires were employed to assess NMS symptoms across the following domains: (1) neuropsychiatric (2) gastrointestinal (3) sleep (4) sensory (5) autonomic (6) sexual. Health related quality of life (HRQoL), functional status and management were also evaluated.ResultsNMS were common in early PD. More than half of the PD cases had hyposmia, pain, fatigue, sleep disturbance or urinary dysfunction. PD cases had worse HRQoL scores than controls (OR 4.1, p<0.001) with depression, anxiety and pain being stronger drivers than MDS-UPDRS motor scores. Quality of life is affected in early PD, although 23% of participants reported no problems. NMS were rarely treated in routine clinical practice.ConclusionsDespite their major impact on HRQoL, NMS are usually under-recognised and treated. The use of screening tools could improve recognition and treatment of NMS in early PD.

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