scholarly journals Continuous Real-Time in vivo Measurement of Cerebral Nitric Oxide Supports Theoretical Predictions of an Irreversible Switching in Cerebral ROS after Sufficient Exposure to External Toxins

2013 ◽  
Vol 3 (3) ◽  
pp. 351-362 ◽  
Author(s):  
Niall J. Finnerty ◽  
Saidhbhe L. O'Riordan ◽  
John P. Lowry ◽  
Mathieu Cloutier ◽  
Peter Wellstead
Keyword(s):  
Nitric Oxide ◽  
Real Time ◽  
Oxide Supports ◽  
In Vivo Measurement ◽  
Theoretical Predictions

Real-Time Quantitation of Renal Ischemia Using Targeted Microbubbles: In-vivo Measurement of P-selectin Expression

2009 ◽  
Vol 23 (3) ◽  
pp. 373-378 ◽  
Author(s):  
Sero Andonian ◽  
Tonya Coulthard ◽  
Arthur D. Smith ◽  
Pravin S. Singhal ◽  
Benjamin R. Lee
Keyword(s):  
Real Time ◽  
Renal Ischemia ◽  
In Vivo Measurement ◽  
Targeted Microbubbles

Real Time In Vivo Measurement of Ascorbate in the Brain Using Carbon Nanotube-Modified Microelectrodes

2013 ◽  
Vol 25 (7) ◽  
pp. 1757-1763 ◽  
Author(s):  
Nuno R. Ferreira ◽  
Ricardo M. Santos ◽  
João Laranjinha ◽  
Rui M. Barbosa
Keyword(s):  
Carbon Nanotube ◽  
Real Time ◽  
In Vivo Measurement ◽  
The Brain

scholarly journals In vivo characterisation of a Nafion®-modified Pt electrode for real-time nitric oxide monitoring in brain extracellular fluid

2012 ◽  
Vol 4 (2) ◽  
pp. 550 ◽  
Author(s):  
Niall J. Finnerty ◽  
Saidhbhe L. O'Riordan ◽  
Finbar O. Brown ◽  
Pier A. Serra ◽  
Robert D. O'Neill ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Real Time ◽  
Extracellular Fluid ◽  
Pt Electrode ◽  
Brain Extracellular Fluid

Mechanisms of polymicrobial sepsis-induced ileus

2004 ◽  
Vol 287 (3) ◽  
pp. G685-G694 ◽  
Author(s):  
Marcus Overhaus ◽  
Sandra Tögel ◽  
Michael A. Pezzone ◽  
Anthony J. Bauer
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Real Time ◽  
Inducible Nitric Oxide Synthase ◽  
Gastrointestinal Transit ◽  
Polymicrobial Sepsis ◽  
Rt Pcr ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Sepsis frequently occurs after hemorrhage, trauma, burn, or abdominal surgery and is a leading cause of morbidity and mortality in severely ill patients. We performed experiments to delineate intestinal molecular and functional motility consequences of polymicrobial sepsis in the clinically relevant cecal ligation and puncture (CLP) sepsis model. CLP was performed on male Sprague-Dawley rats. Gastrointestinal transit, colonic in vivo pressure recordings, and in vitro muscle contractions were recorded. Histochemistry was performed for macrophages, monocytes, and neutrophils. Inflammatory gene expressions were quantified by real-time RT-PCR. CLP delayed gastrointestinal transit, decreased colonic pressures, and suppressed in vivo circular muscle contractility of the jejunum and colon over a 4-day period. A leukocytic infiltrate of monocytes and neutrophils developed over 24 h. Real-time RT-PCR demonstrated a significant temporal elevation in IL-6, IL-1β, monocyte chemoattractant protein-1, and inducible nitric oxide synthase, with higher expression levels of IL-6 and inducible nitric oxide synthase in colonic extracts compared with small intestine. Polymicrobial CLP sepsis induces a complex inflammatory response within the intestinal muscularis with the recruitment of leukocytes and elaboration of mediators that inhibit intestinal muscle function. Differences were elucidated between endotoxin and CLP models of sepsis, as well as a heterogeneous regional response of the gastrointestinal tract to CLP. Thus the intestine is not only a source of bacteremia but also an important target of bacterial products with major functional consequences to intestinal motility and the generation of cytokines, which participate in the development of multiple organ failure.

REAL-TIME QUANTITATION OF RENAL ISCHEMIA USING TARGETED MICROBUBBLES: IN VIVO MEASUREMENT OF P-SELECTIN EXPRESSION

2009 ◽  
Vol 181 (4S) ◽  
pp. 807-807
Author(s):  
Sero Andonian ◽  
Tonya Coulthard ◽  
Pravin S Singhal ◽  
Arthur D Smith ◽  
Benajamin R Lee
Keyword(s):  
Real Time ◽  
Renal Ischemia ◽  
In Vivo Measurement ◽  
Targeted Microbubbles
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