scholarly journals 64Cu production by 14 MeV neutron beam

2020 ◽  
Vol 22 (2-3) ◽  
pp. 257-264
Author(s):  
M. Capogni ◽  
M. Capone ◽  
A. Pietropaolo ◽  
A. Fazio ◽  
G. Dellepiane ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Neutron Beam ◽  
Nuclear Reactions ◽  
Target Material ◽  
Production Method ◽  
Research Center ◽  
Radiochemical Analysis ◽  
Fusion Neutron ◽  
Primary Activity ◽  
Activity Measurements

64Cu is an emerging radionuclide of great interest in personalized nuclear medicine. It is produced by a cyclotron via the reaction 64Ni(p,n)64Cu. This production method increased during the last decades, because small biomedical cyclotrons can be easily installed close to the nuclear medicine department of a hospital. As a matter of fact, 64Ni is a very expensive target material. For this reason, an alternative 64Cu production method was investigated at ENEA by using the quasi-monochromatic 14 MeV fusion neutron beam made available at the Frascati Neutron Generator (FNG) located at the ENEA – Frascati Research Center. In particular, two nuclear reactions were studied: 65Cu(n,2n)64Cu and 64Zn(n,p)64Cu. The radiochemical analysis of the activated samples was performed at the ENEA-NMLNWM laboratory located in ENEA-Casaccia Research Center. The activity measurements were carried out at the ENEA-INMRI, located in the ENEA-Casaccia Research Center, with high metrological level conditions and by assuring their traceability to the 64Cu primary activity standard here developed and maintained. A prediction of the 64Cu production by means of the high-brilliance 14 MeV neutron source named Sorgentina is also discussed.

scholarly journals The ISOLPHARM project: A New ISOL production method of high specific activity beta-emitting radionuclides as radiopharmaceutical precursors

2018 ◽  
Vol 48 ◽  
pp. 1860103 ◽  
Author(s):  
A. Andrighetto ◽  
F. Borgna ◽  
M. Ballan ◽  
S. Corradetti ◽  
E. Vettorato ◽  
...  
Keyword(s):  
Nuclear Reactions ◽  
Specific Activity ◽  
Isotope Separation ◽  
High Specific Activity ◽  
Target Material ◽  
Mass Range ◽  
Production Method ◽  
Radioactive Isotopes ◽  
Innovative Technology ◽  
On Line

The ISOLPHARM project explores the feasibility of exploiting an innovative technology to produce extremely high specific activity beta-emitting radionuclides as radiopharmaceutical precursors. This technique is expected to produce radiopharmaceuticals that are virtually mainly impossible to obtain in standard production facilities, at lower cost and with less environmental impact than traditional techniques. The groundbreaking ISOLPHARM method investigated in this project has been granted an international patent (INFN). As a component of the SPES (Selective Production of Exotic Species) project at the Istituto Nazionale di Fisica Nucleare–Laboratori Nazionali di Legnaro (INFN–LNL), a new facility will produce radioactive ion beams of neutron-rich nuclei with high purity and a mass range of 80–160 amu. The radioactive isotopes will result from nuclear reactions induced by accelerating 40 MeV protons in a cyclotron to collide on a target of UC[Formula: see text]. The uranium in the target material will be [Formula: see text]U, yielding radioactive isotopes that belong to elements with an atomic number between 28 and 57. Isotope separation on line (ISOL) is adopted in the ISOLPHARM project to obtain pure isobaric beams for radiopharmaceutical applications, with no isotopic contaminations in the beam or subsequent trapping substrate. Isobaric contaminations may potentially affect radiochemical and radionuclide purity, but proper methods to separate chemically different elements can be developed.

A Feasibility Study of an Application of Fusion Neutron Beam Source Based on Cylindrical Discharge Device for Cancer Therapy

2013 ◽  
Vol 64 (2) ◽  
pp. 379-383
Author(s):  
Yasunori Nakai ◽  
Kazuyuki Noborio ◽  
Yuto Takeuchi ◽  
Ryuta Kasada ◽  
Yasushi Yamamoto ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Feasibility Study ◽  
Neutron Beam ◽  
Beam Source ◽  
Fusion Neutron ◽  
Discharge Device

scholarly journals Vortex Target: A New Design for a Powder-in-Gas Target for Large-Scale Radionuclide Production

Instruments ◽  
2019 ◽  
Vol 3 (2) ◽  
pp. 24 ◽  
Author(s):  
Gerrie Lange
Keyword(s):  
Large Scale ◽  
Gas Flow ◽  
Nuclear Reactions ◽  
Volume Ratio ◽  
Target Material ◽  
Thick Target ◽  
Beam Power ◽  
Design Work ◽  
Radionuclide Production ◽  
Gas Target

This paper presents a design and working principle for a combined powder-in-gas target. The excellent surface-to-volume ratio of micrometer-sized powder particles injected into a forced carrier-gas-driven environment provides optimal beam power-induced heat relief. Finely dispersed powders can be controlled by a combined pump-driven inward-spiraling gas flow and a fan structure in the center. Known proton-induced nuclear reactions on isotopically enriched materials such as 68Zn and 100Mo were taken into account to be conceptually remodeled as a powder-in-gas target assembly, which was compared to thick target designs. The small irradiation chambers that were modeled in our studies for powdery ‘thick’ targets with a mass thickness (g/cm2) comparable to 68Zn and 100Mo resulted in the need to load 2.5 and 12.6 grams of the isotopically enriched target material, respectively, into a convective 7-bar pressured helium cooling circuit for irradiation, with ion currents and entrance energies of 0.8 (13 MeV) and 2 mA (20 MeV), respectively. Current densities of ~2 μA/mm2 (20 MeV), induces power loads of up to 4 kW/cm2. Moreover, the design work showed that this powder-in-gas target concept could potentially be applied to other radionuclide production routes that involve powdery starting materials. Although the modeling work showed good convective heat relief expectations for micrometer-sized powder, more detailed mathematical investigation on the powder-in-gas target restrictions, electrostatic behavior, and erosion effects during irradiation are required for developing a real prototype assembly.

Neutron Beam Generation by the Cylindrical Fusion Neutron Source

2009 ◽  
Vol 56 (2) ◽  
pp. 761-765 ◽  
Author(s):  
Yasushi Yamamoto ◽  
Atsunori Ishidou ◽  
Kazuyuki Noborio ◽  
Satoshi Konishi
Keyword(s):  
Neutron Source ◽  
Neutron Beam ◽  
Beam Generation ◽  
Fusion Neutron ◽  
Fusion Neutron Source

ISOSPIN SYMMETRY BREAKING AND BRANCHING RATIO IN THE DEUTERON REACTIONS AT VERY LOW ENERGIES

2011 ◽  
Vol 20 (02) ◽  
pp. 576-581 ◽  
Author(s):  
A.I. KILIÇ ◽  
K. CZERSKI ◽  
P. HEIDE ◽  
A. HUKE ◽  
G. RUPRECHT ◽  
...  
Keyword(s):  
Cross Sections ◽  
Nuclear Reactions ◽  
Branching Ratio ◽  
Target Material ◽  
Direct Reaction ◽  
Isospin Symmetry ◽  
Total Cross Sections ◽  
Theoretical Approaches ◽  
Low Energies ◽  
Isospin Symmetry Breaking

The target-material dependence of the neutron-proton branching ratio and breaking of the isospin symmetry in the the 2H(d, n)3He and 2H(d, p)3H reactions at very low deuteron energies have been investigated. Angular distributions and total cross sections of the proton and neutron mirror channels have been measured for nuclear reactions taking place in different metallic environments. For Sr , Li , Na targets, we have found a first evidence for an alteration of the neutron-proton branching ratio and angular anisotropy of the neutron channel. We discuss various theoretical approaches explaining isospin mixing effects both in gas and metallic target experiments including a deuteron polarization in the crystal lattice. Direct reaction contribution has been calculated within the zero range distorted wave Born approximation (DWBA).

Cross sections of proton induced nuclear reactions on enriched 111Cd and 112Cd for the production of 111In for use in nuclear medicine

1994 ◽  
Vol 45 (2) ◽  
pp. 239-249 ◽  
Author(s):  
F. Tárkányi, ◽  
F. Szelecsényi ◽  
P. Kopecký ◽  
T. Molnár ◽  
L. Andó ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Cross Sections ◽  
Nuclear Reactions

The Professional Retraining Program in Radiotherapy for Medical Physicists

2018 ◽  
pp. 68-73
Author(s):  
А. Черняев ◽  
A. Chernyaev ◽  
П. Борщеговская ◽  
P. Borschegovskaya ◽  
С. Варзарь ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Ionizing Radiation ◽  
Medical Research ◽  
Radiation Safety ◽  
Research Center ◽  
State University ◽  
National Medical ◽  
Medical Physicists ◽  
Radiation Medicine ◽  
Moscow State University

The article assesses the personnel situation in the field of domestic radiation therapy and nuclear medicine. Despite the fact that in recent years there has been a significant re-equipping of Russian medical centers with the latest devices, the quantitative indicators of medical equipment normalized for the number of residents of the country are still significantly inferior to the indexes other countries. And this problem is greatly aggravated by the insufficient number of specialists who can work on the equipment supplied. First and foremost, this refer to medical physicists who are responsible not only for ensuring the required accuracy when applying a dose of ionizing radiation to the tumor, but also for ensuring radiation safety when working with sources of ionizing radiation. A continuing vocational educational retraining program covering development, operation and application of high-tech systems for radiotherapy is being proposed. This program was developed and tested at the Department of Physics of Accelerators and Radiation Medicine of the Physical Faculty of M.V. Lomonosov Moscow State University with the support of the Rusnano Foundation for Educational Programs. The co-executors in the development and approbation of the Program were the National Medical Research Center of Radiology, A.I. Burnasyan Federal Medical Biophysical Center of the FMBA of Russia. Invited experts in the process of developing the Program were scientists and specialists of the Bauman MSTU, Tomsk Polytechnic University, NRNU MEPhI, N.N. Blokhin National Medical Research Center of Oncology. As a result of a professional educational program, the necessary professional skills for working as specialists in radiotherapy units and nuclear medicine centers are formed, which will successfully solve the problem of professional human resources for the clinical centers of Russia. The program was developed and successfully implemented at the Department of Physics of Accelerators and Radiation Medicine of the Physics Department of M.V. Lomonosov Moscow State University. The need to develop a program of assessment of medical physicists, which are working at the moment, is being considered. This will guarantee a high level of knowledge necessary for full participation in the medical process and making responsible decisions on the therapeutic use of radiation devices and ensuring radiation safety of patients and personnel.

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