Waist Circumference and Domain-Specific Cognitive Function among Non-demented Japanese Older Adults Stratified by Sex: Results from the Takashima Cognition Study

2020 ◽  
pp. 1-2
Author(s):  
Takashi Waki ◽  
Sachiko Tanaka-Mizuno ◽  
Naoyuki Takashima ◽  
Hajime Takechi ◽  
Takehito Hayakawa ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Waist Circumference ◽  
Domain Specific ◽  
Japanese Older Adults

scholarly journals Waist Circumference and Domain-Specific Cognitive Function Among Non-Demented Japanese Older Adults Stratified by Sex: Results from the Takashima Cognition Study

2020 ◽  
Vol 73 (3) ◽  
pp. 887-896
Author(s):  
Takashi Waki ◽  
Sachiko Tanaka-Mizuno ◽  
Naoyuki Takashima ◽  
Hajime Takechi ◽  
Takehito Hayakawa ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Waist Circumference ◽  
Domain Specific ◽  
Japanese Older Adults

scholarly journals Association of Gait With Global and Domain-specific Cognitive Function Among Community-dwelling Older Adults: A Cross-sectional Study

2021 ◽  
Author(s):  
WEN HAO ◽  
Wenjing Zhao ◽  
Takashi Kimura ◽  
Shigekazu Ukawa ◽  
Ken Kadoya ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Initial Contact ◽  
Sectional Study ◽  
Cross Sectional ◽  
Domain Specific ◽  
Global Cognitive Function ◽  
Gait Parameters

Abstract Background: Gait is associated with cognitive function and is a trait marker of dementia; however, research on gait and cognitive function usually concentrates on several individual gait parameters. This study used wearable sensors to measure gait parameters in different aspects and comprehensively explored the association of gait with global cognitive function and domain-specific cognitive function.Methods: The data of this cross-sectional study were obtained from 236 community-dwelling Japanese older adults (125 men and 111 women) aged 70–81 years. Gait was measured by asking participants to walk a 6-meter course and back using the Physilog® sensors (GaiUp®, Switzerland). Global cognitive function and cognitive domains were evaluated by face-to-face interviews using the Japanese version of the Montreal Cognitive Assessment. Twenty gait parameters were summarized as independent gait factors using factor analysis. A generalized linear model and linear regression model were used to explore the relationship of gait with global cognitive function and domain-specific cognitive function adjusted for several confounding factors.Results: Factor analysis yielded four gait factors: general cycle, initial contact, propulsion, and mid-swing. Among them, general cycle factor was significantly associated with global cognitive function (β=-0.565, [-0.967, -0.163]), executive function (P=0.012), and memory (P=0.045); initial contact was associated with executive function (P=0.019).Conclusion: Better gait was related to better cognitive function, especially the general cycle, which was correlated with both global and domain-specific cognitive function. The predictive value should be examined in future cohort studies.

scholarly journals Plasma MCP-1 and changes on cognitive function in community-dwelling older adults

2022 ◽  
Vol 14 (1) ◽  
Author(s):  
Juan Luis Sanchez-Sanchez ◽  
Kelly V. Giudici ◽  
Sophie Guyonnet ◽  
Julien Delrieu ◽  
Yan Li ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Episodic Memory ◽  
Cognitive Decline ◽  
Continuous Variable ◽  
Community Dwelling ◽  
Clinical Dementia Rating ◽  
Delayed Recall ◽  
Domain Specific

Abstract Background Monocyte Chemoattractant Protein-1 (MCP-1), a glial-derived chemokine, mediates neuroinflammation and may regulate memory outcomes among older adults. We aimed to explore the associations of plasma MCP-1 levels (alone and in combination with β-amyloid deposition—Aβ42/40) with overall and domain-specific cognitive evolution among older adults. Methods Secondary analyses including 1097 subjects (mean age = 75.3 years ± 4.4; 63.8% women) from the Multidomain Alzheimer Preventive Trial (MAPT). MCP-1 (higher is worse) and Aβ42/40 (lower is worse) were measured in plasma collected at year 1. MCP-1 in continuous and as a dichotomy (values in the highest quartile (MCP-1+)) were used, as well as a dichotomy of Aβ42/40. Outcomes were measured annually over 4 years and included the following: cognitive composite z-score (CCS), the Mini-Mental State Examination (MMSE), and Clinical Dementia Rating (CDR) sum of boxes (overall cognitive function); composite executive function z-score, composite attention z-score, Free and Cued Selective Reminding Test (FCSRT - memory). Results Plasma MCP-1 as a continuous variable was associated with the worsening of episodic memory over 4 years of follow-up, specifically in measures of free and cued delayed recall. MCP-1+ was associated with worse evolution in the CCS (4-year between-group difference: β = −0.14, 95%CI = −0.26, −0.02) and the CDR sum of boxes (2-year: β = 0.19, 95%CI = 0.06, 0.32). In domain-specific analyses, MCP-1+ was associated with declines in the FCSRT delayed recall sub-domains. In the presence of low Aβ42/40, MCP-1+ was not associated with greater declines in cognitive functions. The interaction with continuous biomarker values Aβ42/40× MCP-1 × time was significant in models with CDR sum of boxes and FCSRT DTR as dependent variables. Conclusions Baseline plasma MCP-1 levels were associated with longitudinal declines in overall cognitive and episodic memory performance in older adults over a 4-year follow-up. How plasma MCP-1 interacts with Aβ42/40 to determine cognitive decline at different stages of cognitive decline/dementia should be clarified by further research. The MCP-1 association on cognitive decline was strongest in those with amyloid plaques, as measured by blood plasma Aβ42/40.

scholarly journals Alcohol Consumption and Domain-Specific Cognitive Function in Older Adults: Longitudinal Data From the Johns Hopkins Precursors Study

2010 ◽  
Vol 66B (1) ◽  
pp. 39-47 ◽  
Author(s):  
A. L. Gross ◽  
G. W. Rebok ◽  
D. E. Ford ◽  
A. Y. Chu ◽  
J. J. Gallo ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Alcohol Consumption ◽  
Longitudinal Data ◽  
Domain Specific

scholarly journals Development of a Questionnaire to Evaluate Older Adults’ Total Sedentary Time and Sedentary Time With Cognitive Activity

2021 ◽  
pp. 089198872110064
Author(s):  
Satoshi Kurita ◽  
Takehiko Doi ◽  
Kota Tsutsumimoto ◽  
Sho Nakakubo ◽  
Hideaki Ishii ◽  
...  
Keyword(s):  
Older Adults ◽  
Executive Function ◽  
Cognitive Function ◽  
Processing Speed ◽  
Sedentary Time ◽  
Neuropsychological Test ◽  
Cognitive Activity ◽  
Measured Time ◽  
Validity Measures ◽  
Japanese Older Adults

This study aimed to develop a questionnaire for evaluating total sedentary time (ST) and ST with cognitive activity, and to examine the association between ST and cognitive function among Japanese older adults. The questionnaire to evaluate ST comprised 12 items regarding behavior in specific settings, including 8 items on ST with cognitive activity, in a usual week. Older adults aged ≥75 years who participated in a health check-up assessing cognitive function completed the developed questionnaire and subsequently wore an accelerometer and recorded a diary of ST with cognitive activity for a week as validity measures. Cognitive function was assessed with neuropsychological tests covering 4 domains: memory, attention, executive function, and processing speed. Fifty-two participants were included in the validity analysis. Spearman’s correlation coefficient indicated fair-to-good agreement between the questionnaire-measured and the diary-measured time for ST with cognitive activity (r = 0.59, p < 0.001), but this was not the case for total ST. Bland-Altman plots showed that the questionnaire-measured total ST contained proportional bias (r = 0.51, p < 0.001). Multiple regression analysis (n = 49) showed longer questionnaire-measured ST with cognitive activity was significantly associated with better neuropsychological test scores (attention: β = -0.38, p = 0.025; executive function: β = -0.46, p = 0.003; and processing speed: β = 0.31, p = 0.041), while total ST was not associated with better cognitive performance. The developed questionnaire showed acceptable validity to measure ST with cognitive activity, which was found to be protectively associated with cognitive function.

scholarly journals Relationship Between Domain-Specific Cognitive Function and Speech-in-Noise Performance in Older Adults: The Atherosclerosis Risk in Communities Hearing Pilot Study

2019 ◽  
Vol 28 (4) ◽  
pp. 1006-1014 ◽  
Author(s):  
Sara K. Mamo ◽  
Nicholas S. Reed ◽  
A. Richey Sharrett ◽  
Marilyn S. Albert ◽  
Josef Coresh ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Pilot Study ◽  
Cognitive Status ◽  
Noise Performance ◽  
Atherosclerosis Risk In Communities ◽  
Aural Rehabilitation ◽  
Domain Specific ◽  
Speech In Noise ◽  
Atherosclerosis Risk

Purpose The purpose of this study was to investigate associations between performance on a clinical speech-in-noise measure with a comprehensive neurocognitive battery of tests. Method A group of older adults ( N = 250, M age = 77 years, age range: 67.3–89.1 years) enrolled in the Atherosclerosis Risk in Communities Neurocognitive Study took part in the hearing pilot study (2013) that included testing for audiometric thresholds and speech-in-noise performance (Quick Speech-in-Noise Test; Killion, Niquette, Gudmundsen, Revit, & Banerjee, 2004). This research study analyzed the associations between domain-specific cognitive function and speech-in-noise performance after adjusting for hearing thresholds and other demographic and cardiovascular factors. Results Multivariable-adjusted associations were found between all cognitive domains and speech-in-noise performance in the full sample, but the observed associations varied when participants with varying levels of moderate to moderately severe hearing loss were excluded from the analysis. Conclusions The findings are discussed in terms considering the cognitive status of older adults in relation to their speech-in-noise performance during audiological evaluation and implications for aural rehabilitation.

scholarly journals Examining the Association between Life-Space Mobility and Cognitive Function in Older Adults: A Systematic Review

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Nileththi A. De Silva ◽  
Michael A. Gregory ◽  
Shree S. Venkateshan ◽  
Chris P. Verschoor ◽  
Ayse Kuspinar
Keyword(s):  
Mental Health ◽  
Older Adults ◽  
Cognitive Function ◽  
Processing Speed ◽  
Random Effects Model ◽  
Life Space ◽  
Function Learning ◽  
Domain Specific ◽  
The Relationship ◽  
Moderate Relationship

Purpose. The purpose of this review is to investigate the relationship between life-space mobility and cognition in older adults.Methods. MEDLINE, Embase, CINAHL, and PsycINFO were searched through December 2018 for studies containing measures of life-space mobility and cognitive function. Two independent reviewers screened studies. Eligible studies were combined using a random-effects model, and heterogeneity was assessed using theI2.Results. Thirty-five articles were identified for review. A moderate and statistically significant association (pooledr = 0.30, 95% confidence interval 0.19 to 0.40.) was observed between life-space mobility and cognition among nine studies. Life-space mobility demonstrated small-to-moderate associations with domain-specific cognitive functioning, particularly executive function, learning, memory, and processing speed. Furthermore, individuals who had restricted life-space mobility (Life-Space Assessment ≤ 40) experienced a steeper decline in cognition (β = 0.56 andp = 0.0471) compared to those who did not (Life-Space Assessment ≥ 41).Conclusion. This review examined the association between life-space mobility and cognitive function in older adults. The results suggest that a moderate relationship between life-space mobility and cognition exists, whether adjusted or unadjusted for covariates such as sociodemographics, mental health, functional capacity, and comorbidities.

scholarly journals Cognitive Function of Elderly Persons in Japanese Neighborhoods: The Role of Street Layout

2019 ◽  
Vol 34 (6) ◽  
pp. 381-389 ◽  
Author(s):  
Mohammad Javad Koohsari ◽  
Tomoki Nakaya ◽  
Gavin R. McCormack ◽  
Ai Shibata ◽  
Kaori Ishii ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Cognitive Function ◽  
Elderly Persons ◽  
Cross Sectional ◽  
Home Location ◽  
Street Layout ◽  
Japanese Older Adults ◽  
State Examination

Objectives:The aims of this study were to examine (a) associations of two metric and space syntax measures of street layout with the cognitive function of Japanese older adults and (b) the extent to which objectively assessed physical activity mediated such associations.Methods:Cross-sectional data from 277 older adults who lived in Japan were used. Street layout attributes were objectively calculated for each participant’s geocoded home location. The Mini-Mental State Examination was used to evaluate cognitive function. Physical activity was objectively assessed with accelerometers.Results:There was a statistically significant negative association between street integration and the odds of having cognitive impairment. Objectively assessed physical activity did not attenuate this relationship.Conclusions:Our findings provide unique evidence regarding the importance of the topological aspects of street layouts in (re)designing neighborhoods to support mental illness.

scholarly journals P4-426: WAIST CIRCUMFERENCE AND DOMAIN-SPECIFIC COGNITIVE FUNCTION AMONG THE NON-DEMENTED JAPANESE ELDERLY: RESULTS FROM THE TAKASHIMA STUDY

2019 ◽  
Vol 15 ◽  
pp. P1466-P1466
Author(s):  
Takashi Waki ◽  
Sachiko Tanaka ◽  
Naoyuki Takashima ◽  
Hajime Takechi ◽  
Takehito Hayakawa ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Waist Circumference ◽  
Domain Specific ◽  
Japanese Elderly
Sign in / Sign up

Export Citation Format

Share Document