Long-term survival of the exon 10 insertional cystic fibrosis mutant mouse is a consequence of low level residual wild-type Cftr gene expression

1994 ◽  
Vol 5 (8) ◽  
pp. 465-472 ◽  
Author(s):  
J. R. Dorin ◽  
B. J. Stevenson ◽  
S. Fleming ◽  
E. W. F. W. Alton ◽  
P. Dickinson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cystic Fibrosis ◽  
Mutant Mouse ◽  
Cftr Gene ◽  
Wild Type ◽  
Term Survival ◽  
Long Term Survival ◽  
Low Level ◽  
Exon 10

Predictive value of gene expression profiling for long-term survival after heart transplantation

2017 ◽  
Vol 41 ◽  
pp. 27-31 ◽  
Author(s):  
Buntaro Fujita ◽  
Emir Prashovikj ◽  
Uwe Schulz ◽  
Jochen Börgermann ◽  
Jakub Sunavsky ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Transplantation ◽  
Gene Expression Profiling ◽  
Predictive Value ◽  
Expression Profiling ◽  
Term Survival ◽  
Long Term Survival

Long-term survival in a patient with low-level inflammatory markers and liver metastasis, converted resectable by TACE

Immunotherapy ◽  
2017 ◽  
Vol 9 (13) ◽  
pp. 1067-1069
Author(s):  
Malkhaz Mizandari ◽  
Natela Paksashvili ◽  
Nino Kikodze ◽  
Tamta Azrumelashvili ◽  
Ia Pantsulaia ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Inflammatory Markers ◽  
Term Survival ◽  
Long Term Survival ◽  
Low Level

Predictors of Long Term Survival in Patients With Cystic Fibrosis Following Lung Transplantation

2018 ◽  
Vol 37 (4) ◽  
pp. S446
Author(s):  
C.A. Robinson ◽  
A. Deibel ◽  
M.M. Schuurmans ◽  
I. Inci ◽  
C. Benden
Keyword(s):  
Cystic Fibrosis ◽  
Lung Transplantation ◽  
Term Survival ◽  
Long Term Survival

Long-term survival in primary glioblastoma revisited: The contribution of isocitrate dehydrogenase mutations.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 2027-2027
Author(s):  
Michael Weller ◽  
Bettina Hentschel ◽  
Matthias Simon ◽  
Manfred Westphal ◽  
Gabriele Schackert ◽  
...  
Keyword(s):  
Promoter Methylation ◽  
Mgmt Promoter Methylation ◽  
Molecular Characteristics ◽  
Wild Type ◽  
Who Grade ◽  
Term Survival ◽  
Long Term Survival ◽  
Tp53 Mutations ◽  
Mgmt Promoter

2027 Background: The determinants of long-term survival in glioblastoma have remained largely obscure. Isocitrate dehydrogenase (IDH) 1 or 2 mutations are common in WHO grade 2/3 gliomas, but rare in primary glioblastomas, and associated with longer survival. Methods: We compared clinical and molecular characteristics of 69 patients with centrally confirmed glioblastoma and survival > 36 months (LTS-36), including 33 patients surviving > 60 months (LTS-60), with 259 patients surviving < 36 months. MGMT promoter methylation, 1p/19q codeletions, EGFR amplification, TP53 mutations and IDH1/2mutations were determined by standard techniques. Results: The rate of IDH1/2 mutations in LTS-36 patients was 34% (23/67 patients) as opposed to 4.3% in controls (11/257 patients). Long-term survivors with IDH1/2 -mutant glioblastomas were younger, had almost no EGFR amplifications, but exhibited more often 1p/19q codeletions and TP53 mutations than LTS patients with IDH1/2 wild-type glioblastomas. Among LTS-36 patients, wild-type TP53 status, MGMT promoter methylation, and absence of EGFR amplification, but not IDH1/2 mutation, were associated with prolonged survival. Among 11 patients with IDH1/2-mutant glioblastomas without long-term survival, the only difference to IDH1/2-mutant long-term survivors was less frequent MGMT promoter methylation. Compared with LTS-36 patients, LTS-60 patients had been treated initially with radiotherapy alone and had TP53 mutations less frequently. Conclusions: IDH1/2 mutations define a subgroup of tumors of LTS patients that exhibit molecular characteristics of WHO grade 2/3 gliomas and secondary glioblastomas. Determinants of LTS with IDH1/2 wild-type glioblastomas, which exhibit typical molecular features of primary glioblastomas, beyond MGMT promoter methylation, remain to be identified.

Recipient Age Impacts Long-Term Survival in Adult Subjects with Cystic Fibrosis after Lung Transplantation

2021 ◽  
Vol 18 (1) ◽  
pp. 44-50
Author(s):  
Jaskaran Sethi ◽  
Andrew Bugajski ◽  
Kapil N. Patel ◽  
Nicole M. Davis ◽  
Keith M. Wille ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Transplantation ◽  
Term Survival ◽  
Long Term Survival ◽  
Recipient Age

scholarly journals Survival of and In Situ Gene Expression by Vibrio vulnificus at Varying Salinities in Estuarine Environments

2007 ◽  
Vol 74 (1) ◽  
pp. 182-187 ◽  
Author(s):  
Melissa K. Jones ◽  
Elizabeth Warner ◽  
James D. Oliver
Keyword(s):  
Gene Expression ◽  
Vibrio Vulnificus ◽  
Natural Habitat ◽  
Term Survival ◽  
Long Term Survival ◽  
Wide Range ◽  
Opportunistic Human Pathogen

ABSTRACT The opportunistic human pathogen Vibrio vulnificus survives in a wide range of ecological environments, which demonstrates its ability to adapt to highly variable conditions. Survival and gene expression under various conditions have been extensively studied in vitro; however, little work has been done to evaluate this bacterium in its natural habitat. Therefore, this study monitored the long-term survival of V. vulnificus in situ and simultaneously evaluated the expression of stress (rpoS, relA, hfq, and groEL) and putative virulence (vvpE, smcR, viuB, and trkA) genes at estuarine sites of varying salinity. Additionally, the survival and gene expression of an rpoS and an oxyR mutant were examined under the same conditions. Differences between the sampling sites in the long-term survival of any strain were not seen. However, differences were seen in the expression of viuB, trkA, and relA but our findings differed from what has been previously shown in vitro. These results also routinely demonstrated that genes required for survival under in vitro stress or host conditions are not necessarily required for survival in the water column. Overall, this study highlights the need for further in situ evaluation of this bacterium in order to gain a true understanding of its ecology and how it relates to its natural habitat.

Sign in / Sign up

Export Citation Format

Share Document