Episodic Memory Decline Predicts Cortical Amyloid Status in Community-Dwelling Older Adults

2011 ◽  
Vol 27 (3) ◽  
pp. 627-637 ◽  
Author(s):  
David G. Darby ◽  
Amy Brodtmann ◽  
Robert H. Pietrzak ◽  
Julia Fredrickson ◽  
Michael Woodward ◽  
...  
Keyword(s):  
Older Adults ◽  
Episodic Memory ◽  
Community Dwelling ◽  
Memory Decline ◽  
Community Dwelling Older Adults

scholarly journals Coping Capacity and Episodic Memory in Older Adults With SMCs: The Mediating Role of Healthy Lifestyle

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 278-279
Author(s):  
Feilong Wang ◽  
Shijie Li ◽  
Kaifa Wang ◽  
Yanni Yang
Keyword(s):  
Older Adults ◽  
Episodic Memory ◽  
Healthy Lifestyle ◽  
Community Dwelling ◽  
Mediating Effect ◽  
Equation Modeling ◽  
Coping Capacity ◽  
Memory Decline ◽  
Mediating Role

Abstract Older adults with subjective memory complaints (SMCs) are at increased risk for episodic memory decline. Episodic memory decline is an important predictor of objective memory impairment (one of the earliest symptoms of Alzheimer’s disease) and an often-suggested criterion of successful memory aging. Therefore, it is important to explore the determinant factors that influence episodic memory in older adults with SMCs. Roy adaptation model and preliminary evidence suggest that older adults with SMCs undergo a coping and adaptation process, a process influenced by many health-related risks and protective factors. This study aimed to explore the relationship between coping capacity and episodic memory, and the mediating role of healthy lifestyle between coping capacity and episodic memory in a sample of 309 community-dwelling older adults with SMCs. Results from the structural equation modeling showed that coping capacity directly affects episodic memory (r=0.629, p＜0.001), and there is a partial mediating effect (60.5%) of healthy lifestyle among this sample of older adults with SMCs. This study demonstrates that coping capacity and adaptation positively correlate with episodic memory in older adults with SMCs, and that these correlations are mediated by healthy lifestyle. The results suggest that older adults with poor coping capacity should be assessed and monitored regularly, and clear lifestyle-related interventions initiated by healthcare providers that promote healthy lifestyles may effectively improve coping capacity and episodic memory in this population group. Note: First author: Feilong Wang, Co-first author: Shijie li, Corresponding author: Yanni Yang

scholarly journals Self-Reported Memory Problems Are Related to Depressive Symptoms in Older Adults With Certain Personality Traits

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 389-390
Author(s):  
Sakshi Bhargava ◽  
Nikki Hill ◽  
Jacqueline Mogle
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Personality Traits ◽  
Community Dwelling ◽  
Memory Decline ◽  
Memory Problems ◽  
Neo Five Factor Inventory ◽  
Cognitively Intact ◽  
Community Dwelling Older Adults

Abstract Self-reported memory problems and depressive symptoms tend to co-occur in older adults; however, this relationship may depend on personality traits and the type of self-reported memory assessed. Using a coordinated analytic framework, this study examined whether neuroticism, extraversion, and conscientiousness moderated the associations of older adults’ self-reported memory with depressive symptoms at between- and within-person levels across three large, longitudinal datasets (range=8-12 years of follow-up) of community-dwelling older adults with no evidence of cognitive impairment (n=427-6,960; Mage: 69.47- 75.94; 72-84% White; 60-64% Female). Assessments of depressive symptoms (GDS-15 or CES-D) and self-reported memory (perceived memory decline, frequency of forgetting, and current memory rating) were taken annually or biennially; personality was assessed via the IPIP or NEO Five-Factor Inventory. Results were largely consistent across datasets. Specifically, between persons, self-reported memory problems (including perceived memory decline, higher frequency of forgetting, and lower current memory rating) were related to higher depressive symptoms only among older adults higher in neuroticism. In one dataset, results supported a protective effect of conscientiousness such that higher frequency of forgetting was related to lower depressive symptoms among older adults higher in this trait. Within persons and across datasets, at times when perceived memory decline was reported, or current memory rating was lower, depressive symptoms tended to be higher only in older adults higher in neuroticism. Results demonstrate the importance of considering personality traits and the type of self-reported memory when examining associations among reports of memory problems and depressive symptoms in cognitively intact older adults.

scholarly journals Spouse-Appraised Memory Functioning Predicts Memory Decline Better Than Subjective Memory Complaints in Community Dwelling Older Adults at Genetic Risk for Alzheimer's Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Youssef Bellaali ◽  
John L. Woodard ◽  
Bernard Hanseeuw ◽  
Adrian Ivanoiu
Keyword(s):  
Older Adults ◽  
Community Dwelling ◽  
Carrier Status ◽  
Subjective Memory Complaints ◽  
Subjective Memory ◽  
Memory Decline ◽  
Apoe Ε4 ◽  
Memory Functioning ◽  
Community Dwelling Older Adults ◽  
With Memory

Objective: Alzheimer's disease (AD) begins with subtle memory decline, years before dementia onset. The presence of subjective memory complaints (SMC) has been proposed as a marker of preclinical AD. However, recent evidence has demonstrated early and progressive loss of awareness of memory difficulties in non-demented older adults harboring AD pathology. We investigated the respective contributions of SMC and spouse-appraised memory functioning (SAM) to predict memory decline in a large cohort of community dwelling older adults.Methods: The Wisconsin Longitudinal Study collected cognitive data from a community-based cohort of 3,583 participants in both 2005 and 2011. The participant and the participant's spouse were each asked to rate the participant's memory functioning using a Likert scale. We predicted change in objective episodic memory with models including baseline SMC, baseline SAM, or both SMC and SAM. We also evaluated an awareness index (SMC minus SAM). We then tested the interaction between Apolipoprotein E (APOE ε4) carrier status and SMC/SAM to evaluate whether the effects were driven by individuals at-risk for AD pathology.Results: In separate models, SMC (−0.081 ± 0.036, p = 0.025) and SAM (−0.084 ± 0.278, p = 0.003) were both associated with memory decline over ~6 years. However, the AI was not significantly associated with memory decline (0.031 ± 0.024, p = 0.19). When both predictors were included in the same model, SAM (−0.074 ± 0.03, p = 0.0092) was associated with memory decline, while SMC was not significant (−0.061 ± 0.04, p = 0.99). The association between SAM and memory decline was stronger in the APOE ε4 carriers than in the non-carriers (APOE-by-SAM interaction: F = 6.07; p = 0.002), and follow up analyses revealed that SAM was particularly predictive of decline only for APOE ε4 carriers. The association between SMC and memory decline was independent of APOE ε4 carrier status (APOE-by-SMC interaction: F = 2.29; p = 0.13).Conclusions: Spouse-appraised memory functioning was more predictive of memory decline than SMC or an awareness index, particularly in APOE ε4 carriers, who are at increased risk for AD pathology.

O4-01-04: Episodic memory decline is associated with cortical amyloid accumulation in healthy community-dwelling, non demented older adults

2011 ◽  
Vol 7 ◽  
pp. S682-S682
Author(s):  
David Darby ◽  
Amy Brodtmann ◽  
Robert Pietrzak ◽  
Michael Woodward ◽  
Victor Villemagne ◽  
...  
Keyword(s):  
Older Adults ◽  
Episodic Memory ◽  
Community Dwelling ◽  
Memory Decline ◽  
Amyloid Accumulation ◽  
Healthy Community
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