scholarly journals Total Plasma Homocysteine and Depressive Symptoms in Older Hispanics

2021 ◽  
pp. 1-7
Author(s):  
Fernando Castro ◽  
Jesús Melgarejo ◽  
Carlos A. Chavez ◽  
Gabriel A. de Erausquin ◽  
Joseph D. Terwilliger ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Sex Education ◽  
Alcohol Intake ◽  
Plasma Homocysteine ◽  
Total Plasma ◽  
Thcy Level ◽  
Logistic Regression Models ◽  
Depression Subscale ◽  
Aging Study ◽  
Intake Stroke

Background: Very few studies have investigated the association between total plasma homocysteine (tHcy) and depressive symptoms in older Hispanics. Objective: To test the hypothesis that high tHcy associate with depressive symptoms in older Hispanics. Methods: A total of 1,418 participants .55 years old from the Maracaibo Aging Study (MAS) underwent standardized neurological, neuropsychiatric, and cardiovascular assessments. The Neuropsychiatric Inventory Depression Subscale (NPId) was used to assess the burden of depressive symptoms. The tHcy levels and other biochemical parameters in blood samples were measured. Multivariable logistic regression models were applied. Results: Participants with depressive symptoms had higher levels of tHcy than those without (15.1 versus 13.9 µmol/L; p = 0.009). Elevated tHcy levels were associated with depressive symptoms after adjusting for age, sex, education, smoking, diabetes, hypertension, alcohol intake, stroke, and dementia (OR = 1.62; 95% CI, 1.10–2.21). Conclusion: Elevated levels of tHcy level were associated with depressive symptoms in older Hispanics living under the nutritional and environmental conditions of a developing country.

The influence of smoking on plasma homocysteine and cysteine levels in passive and active smokers

2004 ◽  
Vol 42 (4) ◽  
Author(s):  
Andrzej Sobczak ◽  
Wladyslaw Wardas ◽  
Wioleta Zielinska-Danch ◽  
Krzysztof Pawlicki
Keyword(s):  
Cigarette Smoking ◽  
Study Groups ◽  
Plasma Homocysteine ◽  
Tobacco Smoke Exposure ◽  
Total Plasma ◽  
Urinary Cotinine ◽  
Thcy Level ◽  
Plasma Thcy ◽  
The Relationship ◽  
Cotinine Concentration

AbstractTotal plasma homocysteine (tHcy) and cysteine (tCys) levels are associated with cardiovascular diseases. One of the determinants that influence their levels is cigarette smoking. The aim of this study was to determine the relationship between plasma levels of both amino acids and urinary cotinine concentration as a reliable biomarker of tobacco smoke exposure. One hundred and seventeen volunteers (61 women and 56 men) aged 19–60 years (mean 40.3±11.0) were included in the study. The study subjects were qualified into non-smokers, passive smokers and active smokers based upon the urinary cotinine concentration. In each particular group, plasma tHcy and tCys levels were measured and evaluated in the whole population and separately in women and men. Statistically insignificant differences in plasma tHcy and tCys levels in the whole group of passive smokers in comparison with non-smokers were observed (11.47 vs. 10.94 μmol/l, p=0.414, and 253.0 vs. 266.9 μmol/l, p=0.163, respectively). However, statistically significant differences in plasma tHcy levels (13.29 vs. 10.94 μmol/l, p=0.011) and in plasma tCys levels (218.2 vs. 266.9 μmol/l, p<0.001) were found in the whole group of active smokers compared with nonsmokers. The Pearson's coefficient (r) for the correlation between plasma tHcy level and urinary cotinine concentration was r=0.630 (p<0.001) in the whole group of active smokers and r=0.480 (p=0.003) in the whole group of passive smokers. The correlation between plasma tCys level and urinary cotinine concentration in both study groups was insignificant. Similar results were obtained when calculated separately for men and women. The results suggest that cigarette smoking is a strong determinant of plasma tHcy level, but it is not a determinant of plasma tCys level.

Everyday Discrimination Experience and Depressive Symptoms in Urban Black, Guyanese, Hispanic, and White Adults

2018 ◽  
Vol 25 (6) ◽  
pp. 445-452 ◽  
Author(s):  
Akiko S. Hosler ◽  
Jamie R. Kammer ◽  
Xiao Cong
Keyword(s):  
New York ◽  
Depressive Symptoms ◽  
Sex Education ◽  
Epidemiologic Studies ◽  
Major Depressive ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Major Depressive Symptoms ◽  
Racial Ethnic ◽  
Everyday Discrimination

BACKGROUND: Discrimination experience is a stressor that may disproportionately affect the mental health of minority populations. AIMS: We examined the association between discrimination experience and depressive symptoms among four urban racial/ethnic groups. METHOD: Cross-sectional community-based health survey data for Black ( n = 434), Guyanese ( n = 180), Hispanic ( n = 173), and White ( n = 809) adults aged ⩾18 years were collected in Schenectady, New York, in 2013. Discrimination experience was measured with the Everyday Discrimination Scale (EDS), and depressive symptoms were measured with the Center for Epidemiologic Studies–Depression (CES-D) scale. Logistic regression models for the association between EDS and major depressive symptoms (CES-D ⩾ 16) were fitted for each racial/ethnic group. The final model adjusted for age, sex, education, income, smoking, alcohol binge drinking, emotional/social support, and perceived stress. RESULTS: The mean EDS scores varied significantly across groups ( p < .001), with 2.6 in Hispanics, 2.2 in Whites, 2.0 in Blacks, and 1.1 in the Guyanese. There was a consistent and significant independent association between EDS and major depressive symptoms in the crude model and at each step of covariate adjustment in each group. Fully adjusted odds ratios were 1.28 (95% confidence interval [CI; 1.16, 1.41]) in Blacks, 1.83 in the Guyanese [1.36, 2.47], 1.23 in Hispanics [1.07, 1.41], and 1.24 [1.16, 1.33] in Whites. The presence of covariates did not significantly modify the main effect in each group. CONCLUSIONS: This study suggests that discrimination experience can be one of the fundamental social causes of depression. It may be feasible to assess discrimination experience as a risk factor of depression in individuals of all racial/ethnic backgrounds.

scholarly journals Are depressive symptoms associated with quality of care in diabetes? Findings from a nationwide population-based study

2021 ◽  
Vol 9 (1) ◽  
pp. e001804
Author(s):  
Andreas Jung ◽  
Yong Du ◽  
Julia Nübel ◽  
Markus A Busch ◽  
Christin Heidemann ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Sex Education ◽  
Population Based ◽  
National Health Survey ◽  
Future Research ◽  
Population Based Study ◽  
Logistic Regression Models ◽  
The Past ◽  
Diagnosed Diabetes

IntroductionWe investigated whether the presence of depressive symptoms among adults with diagnosed diabetes is associated with adverse quality of diabetes care.Research design and methodsThe study population was drawn from the German national health survey ‘German Health Update’ 2014/2015-European Health Interview Survey and included 1712 participants aged ≥18 years with self-reported diabetes during the past 12 months. Depressive symptoms in the past 2 weeks were assessed by the eight-item depression module of the Patient Health Questionnaire (PHQ-8), with PHQ-8 sum score values ≥10 indicating current depressive symptoms. We selected 12 care indicators in diabetes based on self-reported information on care processes and outcomes. Associations of depressive symptoms with those indicators were examined in multivariable logistic regression models with stepwise adjustments.ResultsOverall, 15.6% of adults with diagnosed diabetes reported depressive symptoms, which were higher in women than in men (18.7% vs 12.9%). Adjusted for age, sex, education, social support, health-related behaviors, and diabetes duration, adults with depressive symptoms were more likely to report acute hypoglycemia (OR 1.81, 95% CI 1.13 to 2.88) or hyperglycemia (OR 2.10, 95% CI 1.30 to 3.37) in the past 12 months, long-term diabetes complications (OR 2.30, 95% CI 1.55 to 3.39) as well as currently having a diet plan (OR 2.14, 95% CI 1.39 to 3.29) than adults without depressive symptoms. Significant associations between depressive symptoms and other care indicators were not observed.ConclusionsThe present population-based study of adults with diagnosed diabetes indicates an association between depressive symptoms and adverse diabetes-specific care with respect to outcome but largely not to process indicators. Our findings underline the need for intensified care for persons with diabetes and depressive symptoms. Future research needs to identify underlying mechanisms with a focus on the inter-relationship between diabetes, depression and diabetes-related distress.

Plasma total homocysteine levels and other biochemical parameters in Algerian patients with deep vein thrombosis

Pteridines ◽  
2014 ◽  
Vol 25 (3-4) ◽  
Author(s):  
Mounira Amrane ◽  
Samia Begag ◽  
Zahira Houcher ◽  
Bakhouche Houcher ◽  
Abderrezak Touabti ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Plasma Homocysteine ◽  
Healthy Controls ◽  
Total Plasma ◽  
Thcy Level ◽  
Vein Thrombosis ◽  
Total Homocysteine ◽  
The Mean ◽  
Deep Vein ◽  
Plasma Total Homocysteine

AbstractWe studied total plasma homocysteine levels (tHcy) in Algerian patients with a deep venous thrombosis (DVT). We measured tHcy levels in a total of 99 subjects enrolled in this study, including 40 patients with DVT and 59 healthy controls. The mean tHcy level in the patients was 12.62±8.7 μmol/L and that in the controls was 10.2± 2.1 μmol/L. In a univariate regression model, tHcy concentrations were inversely correlated with triglycerides (TG) (

Total plasma homocysteine values among elderly subjects: Findings from the Maracaibo Aging Study

2006 ◽  
Vol 39 (10) ◽  
pp. 1007-1015 ◽  
Author(s):  
Aldrin E. Molero ◽  
Carmen C. Altimari ◽  
Dariana A. Duran ◽  
Esperanza Garcia ◽  
Gloria Pino-Ramirez ◽  
...  
Keyword(s):  
Plasma Homocysteine ◽  
Elderly Subjects ◽  
Total Plasma ◽  
Aging Study

P3-131: Total plasma homocysteine and depressive symptoms in older hispanics

2015 ◽  
Vol 11 (7S_Part_14) ◽  
pp. P672-P674
Author(s):  
Fernando A. Castro ◽  
Jesus D. Melgarejo ◽  
Joseph H. Lee ◽  
Gladys E. Maestre
Keyword(s):  
Depressive Symptoms ◽  
Plasma Homocysteine ◽  
Total Plasma

Effects of Mixed Dietary Supplements on Total Plasma Homocysteine Concentrations (tHcy): A Randomized, Double-Blind, Placebo-Controlled Trial

2012 ◽  
Vol 82 (4) ◽  
pp. 260-266 ◽  
Author(s):  
Salah E. Gariballa ◽  
Sarah J. Forster ◽  
Hilary J. Powers
Keyword(s):  
Older Patients ◽  
Controlled Trial ◽  
Plasma Homocysteine ◽  
Acute Illness ◽  
Vitamin B ◽  
Total Plasma ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Nutrient Supplement ◽  
Plasma Thcy

Background: Although a number of studies have reported raised total plasma homocysteine (tHcy) concentrations in free-living older people, there are no data on homocysteine response to a mixed nutrient supplement in older patients. A raised plasma homocysteine concentration in older patients is partly a reflection of their co-morbidity, including impaired renal function, and there is uncertainty about the extent to which dietary interventions can improve plasma tHcy. Aim: To determine the plasma tHcy response to dietary supplements during acute illness. Methods: Two-hundred and thirty-six hospitalized, acutely ill older patients, who were part of a randomized double-blind placebo-controlled trial, were assigned to receive a daily oral nutritional supplement drink containing 1.3 mg of vitamin B2, 1.4 mg of vitamin B6, 1.5 μg of B12, 200 μg of folic acid, or a placebo, for 6 weeks. Outcome measures were plasma tHcy concentration at baseline, 6 weeks, and 6 months. Results: The mean plasma tHcy concentration fell among patients given the supplements (mean difference 4.1 µmol/L [95 % C.I, 0.14 to 8.03), p = 0.043], but tHcy concentration increased between 6 weeks and 6 months, after patients stopped taking the supplements [mean difference -2.0 µmol/L (95 % C.I, -03.9 to -0.18), p = 0.033]. About 46 % of patients in the placebo group and 55 % of patients in the supplement group had hyperhomocysteinemia (>14 µmol/L) at baseline compared with 45 % and 29 % at the end of the treatment period. Conclusions: A mixed nutrient supplement containing physiological amounts of B vitamins significantly reduced plasma tHcy concentrations in older patients recovering from acute illness.

Plasma homocysteine and macular thickness in older adults—the Rugao Longevity and Aging Study

Eye ◽  
2021 ◽  
Author(s):  
Hui Zhang ◽  
Hangqi Shen ◽  
Wei Gong ◽  
Xuehui Sun ◽  
Xiaoyan Jiang ◽  
...  
Keyword(s):  
Older Adults ◽  
Plasma Homocysteine ◽  
Macular Thickness ◽  
Aging Study

Diet, total plasma homocysteine concentrations and mortality rates in broiler chickens

2003 ◽  
Vol 83 (3) ◽  
pp. 601-604 ◽  
Author(s):  
S. E. Samuels
Keyword(s):  
Cardiovascular Disease ◽  
Sudden Death ◽  
Broiler Chickens ◽  
Independent Risk Factor ◽  
Total Mortality ◽  
Mortality Rates ◽  
Plasma Homocysteine ◽  
Sudden Death Syndrome ◽  
Total Plasma ◽  
Elevated Plasma

The aim of this study was to determine if total plasma homocysteine (HCY) concentrations and mortality rates due to ascites syndrome and (AS) sudden death syndrome (SDS) in broiler chickens could be lowered by diet. Elevated plasma HCY is an independent risk factor for cardiovascular disease in humans. A total of 828 day-old male broiler chickens (Arbor Acre) were fed, for 6 wk, either a basal practical diet or one supplemented with excess vitamins B6 and B12, folic acid and betaine to stimulate the degradation of HCY. The supplemented diet decreased plasma HCY by 17% (P < 0.05; n = 16 per diet). Total mortality due to AS and SDS was 18% lower in the supplemented diet but this difference was not statistically significant. Key words: Homocysteine, folate, chickens, cardiovascular disease, ascites, sudden death syndrome

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