The influence of smoking on plasma homocysteine and cysteine levels in passive and active smokers

2004 ◽  
Vol 42 (4) ◽  
Author(s):  
Andrzej Sobczak ◽  
Wladyslaw Wardas ◽  
Wioleta Zielinska-Danch ◽  
Krzysztof Pawlicki
Keyword(s):  
Cigarette Smoking ◽  
Study Groups ◽  
Plasma Homocysteine ◽  
Tobacco Smoke Exposure ◽  
Total Plasma ◽  
Urinary Cotinine ◽  
Thcy Level ◽  
Plasma Thcy ◽  
The Relationship ◽  
Cotinine Concentration

AbstractTotal plasma homocysteine (tHcy) and cysteine (tCys) levels are associated with cardiovascular diseases. One of the determinants that influence their levels is cigarette smoking. The aim of this study was to determine the relationship between plasma levels of both amino acids and urinary cotinine concentration as a reliable biomarker of tobacco smoke exposure. One hundred and seventeen volunteers (61 women and 56 men) aged 19–60 years (mean 40.3±11.0) were included in the study. The study subjects were qualified into non-smokers, passive smokers and active smokers based upon the urinary cotinine concentration. In each particular group, plasma tHcy and tCys levels were measured and evaluated in the whole population and separately in women and men. Statistically insignificant differences in plasma tHcy and tCys levels in the whole group of passive smokers in comparison with non-smokers were observed (11.47 vs. 10.94 μmol/l, p=0.414, and 253.0 vs. 266.9 μmol/l, p=0.163, respectively). However, statistically significant differences in plasma tHcy levels (13.29 vs. 10.94 μmol/l, p=0.011) and in plasma tCys levels (218.2 vs. 266.9 μmol/l, p<0.001) were found in the whole group of active smokers compared with nonsmokers. The Pearson's coefficient (r) for the correlation between plasma tHcy level and urinary cotinine concentration was r=0.630 (p<0.001) in the whole group of active smokers and r=0.480 (p=0.003) in the whole group of passive smokers. The correlation between plasma tCys level and urinary cotinine concentration in both study groups was insignificant. Similar results were obtained when calculated separately for men and women. The results suggest that cigarette smoking is a strong determinant of plasma tHcy level, but it is not a determinant of plasma tCys level.

Effects of Mixed Dietary Supplements on Total Plasma Homocysteine Concentrations (tHcy): A Randomized, Double-Blind, Placebo-Controlled Trial

2012 ◽  
Vol 82 (4) ◽  
pp. 260-266 ◽  
Author(s):  
Salah E. Gariballa ◽  
Sarah J. Forster ◽  
Hilary J. Powers
Keyword(s):  
Older Patients ◽  
Controlled Trial ◽  
Plasma Homocysteine ◽  
Acute Illness ◽  
Vitamin B ◽  
Total Plasma ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Nutrient Supplement ◽  
Plasma Thcy

Background: Although a number of studies have reported raised total plasma homocysteine (tHcy) concentrations in free-living older people, there are no data on homocysteine response to a mixed nutrient supplement in older patients. A raised plasma homocysteine concentration in older patients is partly a reflection of their co-morbidity, including impaired renal function, and there is uncertainty about the extent to which dietary interventions can improve plasma tHcy. Aim: To determine the plasma tHcy response to dietary supplements during acute illness. Methods: Two-hundred and thirty-six hospitalized, acutely ill older patients, who were part of a randomized double-blind placebo-controlled trial, were assigned to receive a daily oral nutritional supplement drink containing 1.3 mg of vitamin B2, 1.4 mg of vitamin B6, 1.5 μg of B12, 200 μg of folic acid, or a placebo, for 6 weeks. Outcome measures were plasma tHcy concentration at baseline, 6 weeks, and 6 months. Results: The mean plasma tHcy concentration fell among patients given the supplements (mean difference 4.1 µmol/L [95 % C.I, 0.14 to 8.03), p = 0.043], but tHcy concentration increased between 6 weeks and 6 months, after patients stopped taking the supplements [mean difference -2.0 µmol/L (95 % C.I, -03.9 to -0.18), p = 0.033]. About 46 % of patients in the placebo group and 55 % of patients in the supplement group had hyperhomocysteinemia (>14 µmol/L) at baseline compared with 45 % and 29 % at the end of the treatment period. Conclusions: A mixed nutrient supplement containing physiological amounts of B vitamins significantly reduced plasma tHcy concentrations in older patients recovering from acute illness.

scholarly journals Total Plasma Homocysteine and Depressive Symptoms in Older Hispanics

2021 ◽  
pp. 1-7
Author(s):  
Fernando Castro ◽  
Jesús Melgarejo ◽  
Carlos A. Chavez ◽  
Gabriel A. de Erausquin ◽  
Joseph D. Terwilliger ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Sex Education ◽  
Alcohol Intake ◽  
Plasma Homocysteine ◽  
Total Plasma ◽  
Thcy Level ◽  
Logistic Regression Models ◽  
Depression Subscale ◽  
Aging Study ◽  
Intake Stroke

Background: Very few studies have investigated the association between total plasma homocysteine (tHcy) and depressive symptoms in older Hispanics. Objective: To test the hypothesis that high tHcy associate with depressive symptoms in older Hispanics. Methods: A total of 1,418 participants .55 years old from the Maracaibo Aging Study (MAS) underwent standardized neurological, neuropsychiatric, and cardiovascular assessments. The Neuropsychiatric Inventory Depression Subscale (NPId) was used to assess the burden of depressive symptoms. The tHcy levels and other biochemical parameters in blood samples were measured. Multivariable logistic regression models were applied. Results: Participants with depressive symptoms had higher levels of tHcy than those without (15.1 versus 13.9 µmol/L; p = 0.009). Elevated tHcy levels were associated with depressive symptoms after adjusting for age, sex, education, smoking, diabetes, hypertension, alcohol intake, stroke, and dementia (OR = 1.62; 95% CI, 1.10–2.21). Conclusion: Elevated levels of tHcy level were associated with depressive symptoms in older Hispanics living under the nutritional and environmental conditions of a developing country.

Plasma total homocysteine levels and other biochemical parameters in Algerian patients with deep vein thrombosis

Pteridines ◽  
2014 ◽  
Vol 25 (3-4) ◽  
Author(s):  
Mounira Amrane ◽  
Samia Begag ◽  
Zahira Houcher ◽  
Bakhouche Houcher ◽  
Abderrezak Touabti ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Plasma Homocysteine ◽  
Healthy Controls ◽  
Total Plasma ◽  
Thcy Level ◽  
Vein Thrombosis ◽  
Total Homocysteine ◽  
The Mean ◽  
Deep Vein ◽  
Plasma Total Homocysteine

AbstractWe studied total plasma homocysteine levels (tHcy) in Algerian patients with a deep venous thrombosis (DVT). We measured tHcy levels in a total of 99 subjects enrolled in this study, including 40 patients with DVT and 59 healthy controls. The mean tHcy level in the patients was 12.62±8.7 μmol/L and that in the controls was 10.2± 2.1 μmol/L. In a univariate regression model, tHcy concentrations were inversely correlated with triglycerides (TG) (

Relationship between total plasma homocysteine and the risk of aneurysms – a meta-analysis

VASA ◽  
2020 ◽  
pp. 1-6
Author(s):  
Hanji Zhang ◽  
Dexin Yin ◽  
Yue Zhao ◽  
Yezhou Li ◽  
Dejiang Yao ◽  
...  
Keyword(s):  
Large Scale ◽  
Meta Analysis ◽  
Single Species ◽  
Total Plasma ◽  
Control Groups ◽  
Randomized Controlled ◽  
Randomized Controlled Studies ◽  
The Difference ◽  
The Relationship ◽  
Healthy Participants

Summary: Our meta-analysis focused on the relationship between homocysteine (Hcy) level and the incidence of aneurysms and looked at the relationship between smoking, hypertension and aneurysms. A systematic literature search of Pubmed, Web of Science, and Embase databases (up to March 31, 2020) resulted in the identification of 19 studies, including 2,629 aneurysm patients and 6,497 healthy participants. Combined analysis of the included studies showed that number of smoking, hypertension and hyperhomocysteinemia (HHcy) in aneurysm patients was higher than that in the control groups, and the total plasma Hcy level in aneurysm patients was also higher. These findings suggest that smoking, hypertension and HHcy may be risk factors for the development and progression of aneurysms. Although the heterogeneity of meta-analysis was significant, it was found that the heterogeneity might come from the difference between race and disease species through subgroup analysis. Large-scale randomized controlled studies of single species and single disease species are needed in the future to supplement the accuracy of the results.

Diet, total plasma homocysteine concentrations and mortality rates in broiler chickens

2003 ◽  
Vol 83 (3) ◽  
pp. 601-604 ◽  
Author(s):  
S. E. Samuels
Keyword(s):  
Cardiovascular Disease ◽  
Sudden Death ◽  
Broiler Chickens ◽  
Independent Risk Factor ◽  
Total Mortality ◽  
Mortality Rates ◽  
Plasma Homocysteine ◽  
Sudden Death Syndrome ◽  
Total Plasma ◽  
Elevated Plasma

The aim of this study was to determine if total plasma homocysteine (HCY) concentrations and mortality rates due to ascites syndrome and (AS) sudden death syndrome (SDS) in broiler chickens could be lowered by diet. Elevated plasma HCY is an independent risk factor for cardiovascular disease in humans. A total of 828 day-old male broiler chickens (Arbor Acre) were fed, for 6 wk, either a basal practical diet or one supplemented with excess vitamins B6 and B12, folic acid and betaine to stimulate the degradation of HCY. The supplemented diet decreased plasma HCY by 17% (P < 0.05; n = 16 per diet). Total mortality due to AS and SDS was 18% lower in the supplemented diet but this difference was not statistically significant. Key words: Homocysteine, folate, chickens, cardiovascular disease, ascites, sudden death syndrome

scholarly journals Association between Friends’ Use of Nicotine and Cannabis and Intake of both Substances among Adolescents

2021 ◽  
Vol 18 (2) ◽  
pp. 695
Author(s):  
Rachel Herold ◽  
Rachel Boykan ◽  
Allison Eliscu ◽  
Héctor E. Alcalá ◽  
Maciej L. Goniewicz
Keyword(s):  
New York ◽  
Peer Influence ◽  
Behavioral Problems ◽  
Secondary Analysis ◽  
Cannabis Use ◽  
Urinary Biomarker ◽  
Urinary Cotinine ◽  
Multivariable Analyses ◽  
Cannabis Smoking ◽  
The Relationship

Nicotine and cannabis use are common among adolescents and may be associated with behavioral problems, poor academic outcomes and use disorders. The goals of this analysis were the following: (1) Describe the influence of friends’ nicotine and cannabis smoking and vaping on self-reported use. (2) Describe the relationship between friends’ nicotine and cannabis use on participants’ urinary biomarkers of nicotine (cotinine) and cannabis (11-nor-9-carboxy-Δ⁹tetrahydrocannabinol=THC-COOH). This is a secondary analysis of survey and biomarker data collected in adolescents aged 12–21 between April 2017 and April 2018, in Long Island, New York. Bivariate and multivariable analyses were conducted using SPSS 26. A cutoff value of ≥10 ng/mL was used to signify recent usage for urinary cotinine and THC-COOH levels. Over one-third of the 517 surveyed adolescents reported using tobacco and one-third reported using cannabis. A significant relationship between friends’ substance use and self-use was found. For both tobacco and cannabis, over 90% (p < 0.01) of participants with urinary biomarker levels above cutoff had friends who used the respective substance. Friends’ nicotine and friends’ cannabis use were each independently associated with urinary biomarker levels for those substances (for nicotine, beta = 88.29, p = 0.03; for cannabis, beta = 163.58, p = 0.03). Friends’ use of nicotine and cannabis is associated with adolescents’ intake, as well as the physiological exposure to those substances. These findings underscore the importance of including peer influence in the discussion with adolescents about tobacco and cannabis use.

scholarly journals Race as a Moderator of the Relationship Between Distress Tolerance and Cigarette Smoking

2013 ◽  
Vol 49 (6) ◽  
pp. 708-714 ◽  
Author(s):  
Jennifer Dahne ◽  
Kelcey J. Stratton ◽  
Ruth Brown ◽  
Ananda B. Amstadter ◽  
Carl W. Lejuez ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Distress Tolerance ◽  
The Relationship

Assessment of tobacco smoke exposure in Hong Kong preschool children: questionnaire or urinary cotinine?

2012 ◽  
Vol 13 ◽  
pp. S67-S68
Author(s):  
T.F. Leung ◽  
I.H.S. Chan ◽  
T.C. Liu ◽  
W.C. Chan ◽  
H.Y. Sy ◽  
...  
Keyword(s):  
Hong Kong ◽  
Preschool Children ◽  
Tobacco Smoke ◽  
Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Urinary Cotinine

Association between total plasma homocysteine level and cognitive functions in elderly Egyptian subjects

2013 ◽  
Vol 332 (1-2) ◽  
pp. 86-91 ◽  
Author(s):  
Mahmoud Allam ◽  
Ebtesam Fahmy ◽  
Sahar Abd Elatti ◽  
Hanan Amer ◽  
Noha Abo-krysha ◽  
...  
Keyword(s):  
Cognitive Functions ◽  
Homocysteine Level ◽  
Plasma Homocysteine ◽  
Total Plasma ◽  
Plasma Homocysteine Level
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