scholarly journals Maximizing Safety in the Conduct of Alzheimer’s Disease Fluid Biomarker Research in the Era of COVID-19

2020 ◽  
Vol 76 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Suzanne E. Schindler ◽  
Gregory A. Jicha ◽  
Peter T. Nelson ◽  
C. Dirk Keene ◽  
Kaj Blennow ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biomarker Research ◽  
Fluid Biomarker

O2-07-03: Validating predicted biological effects of Alzheimer's disease associated SNPs using cerebrospinal fluid biomarker levels

2010 ◽  
Vol 6 ◽  
pp. S112-S113 ◽  
Author(s):  
John S.K. Kauwe ◽  
Carlos Cruchaga ◽  
Sarah Bertelsen ◽  
Kevin Mayo ◽  
Wayne Latu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Biological Effects ◽  
Fluid Biomarker

scholarly journals Communicating 5-Year Risk of Alzheimer’s Disease Dementia: Development and Evaluation of Materials that Incorporate Multiple Genetic and Biomarker Research Results

2020 ◽  
pp. 1-14
Author(s):  
Jessica Mozersky ◽  
Sarah Hartz ◽  
Erin Linnenbringer ◽  
Lillie Levin ◽  
Marissa Streitz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Absolute Risk ◽  
Brain Mri ◽  
Community Dwelling ◽  
Educational Materials ◽  
Research Results ◽  
Material Development ◽  
Biomarker Research

Background: Cognitively normal (CN) older adults participating in Alzheimer’s disease (AD) research increasingly ask for their research results—including genetic and neuroimaging findings—to understand their risk of developing AD dementia. AD research results are typically not returned for multiple reasons, including possible psychosocial harms of knowing one is at risk of a highly feared and untreatable disease. Objective: We developed materials that convey information about 5-year absolute risk of developing AD dementia based on research results. Methods: 20 CN older adults who received a research brain MRI result were interviewed regarding their wishes for research results to inform material development (Pilot 1). Following material development, 17 CN older adults evaluated the materials for clarity and acceptability (Pilot 2). All participants were community-dwelling older adults participating in longitudinal studies of aging at a single site. Results: Participants want information on their risk of developing AD dementia to better understand their own health, satisfy curiosity, inform family, and future planning. Some articulated concerns, but the majority wanted to know their risk despite the limitations of information. Participants found the educational materials and results report clear and acceptable, and the majority would want to know their research results after reviewing them. Conclusion: These materials will be used in a clinical study examining the psychosocial and cognitive effects of offering research results to a cohort of CN older adults. Future AD research may incorporate the return of complex risk information to CN older adults, and materials are needed to communicate this information.

Lithium therapy and cerebrospinal fluid biomarker levels in Alzheimer's disease

2005 ◽  
Vol 5 (4) ◽  
pp. 298-300
Author(s):  
Masahiro Maruyama ◽  
Kota Ishizawa ◽  
Naoki Tomita ◽  
Miyako Nemoto ◽  
Hiroyasu Yasuda ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Lithium Therapy ◽  
Fluid Biomarker

scholarly journals Reproducibility of Alzheimer’s Disease Cerebrospinal Fluid-Biomarker Measurements under Clinical Routine Conditions

2018 ◽  
Vol 62 (1) ◽  
pp. 203-212 ◽  
Author(s):  
Jonathan Vogelgsang ◽  
Dirk Wedekind ◽  
Caroline Bouter ◽  
Hans-W. Klafki ◽  
Jens Wiltfang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Clinical Routine ◽  
Fluid Biomarker

Blood and plasma-based proteomic biomarker research in Alzheimer's disease

2013 ◽  
Vol 101-102 ◽  
pp. 1-17 ◽  
Author(s):  
Simone Lista ◽  
Frank Faltraco ◽  
David Prvulovic ◽  
Harald Hampel
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biomarker Research

LONGITUDINAL CEREBROSPINAL FLUID BIOMARKER TRAJECTORIES ALONG THE ALZHEIMER'S DISEASE CONTINUUM: A MULTICENTRE EUROPEAN STUDY

2017 ◽  
Vol 13 (7) ◽  
pp. P924 ◽  
Author(s):  
Alberto Lleó ◽  
Daniel Alcolea ◽  
Pablo Martinez-Lage ◽  
Philip Scheltens ◽  
Lucilla Parnetti ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
European Study ◽  
Fluid Biomarker

Fluid biomarker agreement and interrelation in dementia due to Alzheimer’s disease

2017 ◽  
Vol 125 (2) ◽  
pp. 193-201 ◽  
Author(s):  
Panagiotis Alexopoulos ◽  
◽  
Jennifer Roesler ◽  
Lukas Werle ◽  
Nathalie Thierjung ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fluid Biomarker
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