scholarly journals Tau Protein is Associated with Longitudinal Memory Decline in Cognitively Healthy Subjects with Normal Alzheimer’s Disease Cerebrospinal Fluid Biomarker Levels

2019 ◽  
Vol 70 (1) ◽  
pp. 211-225 ◽  
Author(s):  
Adrià Tort-Merino ◽  
Jaume Olives ◽  
María León ◽  
Claudia Peñaloza ◽  
Natalia Valech ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Tau Protein ◽  
Healthy Subjects ◽  
Memory Decline ◽  
Fluid Biomarker

O2-07-03: Validating predicted biological effects of Alzheimer's disease associated SNPs using cerebrospinal fluid biomarker levels

2010 ◽  
Vol 6 ◽  
pp. S112-S113 ◽  
Author(s):  
John S.K. Kauwe ◽  
Carlos Cruchaga ◽  
Sarah Bertelsen ◽  
Kevin Mayo ◽  
Wayne Latu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Biological Effects ◽  
Fluid Biomarker

scholarly journals Therapeutic potential of astaxanthin and superoxide dismutase in Alzheimer's disease

Open Biology ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 210013
Author(s):  
Vyshnavy Balendra ◽  
Sandeep Kumar Singh
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Superoxide Dismutase ◽  
Antioxidant System ◽  
Tau Protein ◽  
Therapeutic Potential ◽  
Plaque Burden ◽  
Memory Decline ◽  
Endogenous Antioxidants ◽  
The Brain

Oxidative stress, the imbalance of the antioxidant system, results in an accumulation of neurotoxic proteins in Alzheimer's disease (AD). The antioxidant system is composed of exogenous and endogenous antioxidants to maintain homeostasis. Superoxide dismutase (SOD) is an endogenous enzymatic antioxidant that converts superoxide ions to hydrogen peroxide in cells. SOD supplementation in mice prevented cognitive decline in stress-induced cells by reducing lipid peroxidation and maintaining neurogenesis in the hippocampus. Furthermore, SOD decreased expression of BACE1 while reducing plaque burden in the brain. Additionally, Astaxanthin (AST), a potent exogenous carotenoid, scavenges superoxide anion radicals. Mice treated with AST showed slower memory decline and decreased depositions of amyloid-beta (A β ) and tau protein. Currently, the neuroprotective potential of these supplements has only been examined separately in studies. However, a single antioxidant cannot sufficiently resist oxidative damage to the brain, therefore, a combinatory approach is proposed as a relevant therapy for ameliorating pathological changes in AD.

Lithium therapy and cerebrospinal fluid biomarker levels in Alzheimer's disease

2005 ◽  
Vol 5 (4) ◽  
pp. 298-300
Author(s):  
Masahiro Maruyama ◽  
Kota Ishizawa ◽  
Naoki Tomita ◽  
Miyako Nemoto ◽  
Hiroyasu Yasuda ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Lithium Therapy ◽  
Fluid Biomarker

scholarly journals Reproducibility of Alzheimer’s Disease Cerebrospinal Fluid-Biomarker Measurements under Clinical Routine Conditions

2018 ◽  
Vol 62 (1) ◽  
pp. 203-212 ◽  
Author(s):  
Jonathan Vogelgsang ◽  
Dirk Wedekind ◽  
Caroline Bouter ◽  
Hans-W. Klafki ◽  
Jens Wiltfang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Clinical Routine ◽  
Fluid Biomarker
Sign in / Sign up

Export Citation Format

Share Document