scholarly journals Revisiting Criteria for Psychosis in Alzheimer’s Disease and Related Dementias: Toward Better Phenotypic Classification and Biomarker Research

2020 ◽  
Vol 73 (3) ◽  
pp. 1143-1156 ◽  
Author(s):  
Corinne E. Fischer ◽  
Zahinoor Ismail ◽  
James M. Youakim ◽  
Byron Creese ◽  
Sanjeev Kumar ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biomarker Research ◽  
Phenotypic Classification

scholarly journals Communicating 5-Year Risk of Alzheimer’s Disease Dementia: Development and Evaluation of Materials that Incorporate Multiple Genetic and Biomarker Research Results

2020 ◽  
pp. 1-14
Author(s):  
Jessica Mozersky ◽  
Sarah Hartz ◽  
Erin Linnenbringer ◽  
Lillie Levin ◽  
Marissa Streitz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Absolute Risk ◽  
Brain Mri ◽  
Community Dwelling ◽  
Educational Materials ◽  
Research Results ◽  
Material Development ◽  
Biomarker Research

Background: Cognitively normal (CN) older adults participating in Alzheimer’s disease (AD) research increasingly ask for their research results—including genetic and neuroimaging findings—to understand their risk of developing AD dementia. AD research results are typically not returned for multiple reasons, including possible psychosocial harms of knowing one is at risk of a highly feared and untreatable disease. Objective: We developed materials that convey information about 5-year absolute risk of developing AD dementia based on research results. Methods: 20 CN older adults who received a research brain MRI result were interviewed regarding their wishes for research results to inform material development (Pilot 1). Following material development, 17 CN older adults evaluated the materials for clarity and acceptability (Pilot 2). All participants were community-dwelling older adults participating in longitudinal studies of aging at a single site. Results: Participants want information on their risk of developing AD dementia to better understand their own health, satisfy curiosity, inform family, and future planning. Some articulated concerns, but the majority wanted to know their risk despite the limitations of information. Participants found the educational materials and results report clear and acceptable, and the majority would want to know their research results after reviewing them. Conclusion: These materials will be used in a clinical study examining the psychosocial and cognitive effects of offering research results to a cohort of CN older adults. Future AD research may incorporate the return of complex risk information to CN older adults, and materials are needed to communicate this information.

Blood and plasma-based proteomic biomarker research in Alzheimer's disease

2013 ◽  
Vol 101-102 ◽  
pp. 1-17 ◽  
Author(s):  
Simone Lista ◽  
Frank Faltraco ◽  
David Prvulovic ◽  
Harald Hampel
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biomarker Research

scholarly journals Maximizing Safety in the Conduct of Alzheimer’s Disease Fluid Biomarker Research in the Era of COVID-19

2020 ◽  
Vol 76 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Suzanne E. Schindler ◽  
Gregory A. Jicha ◽  
Peter T. Nelson ◽  
C. Dirk Keene ◽  
Kaj Blennow ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biomarker Research ◽  
Fluid Biomarker

The application of lipidomics to biomarker research and pathomechanisms in Alzheimer's disease

2017 ◽  
Vol 30 (2) ◽  
pp. 136-144 ◽  
Author(s):  
Matthew W. Wong ◽  
Nady Braidy ◽  
Anne Poljak ◽  
Perminder S. Sachdev
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biomarker Research

Cognitive control constrains memory attributions

2019 ◽  
Vol 42 ◽  
Author(s):  
Colleen M. Kelley ◽  
Larry L. Jacoby
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Control

Abstract Cognitive control constrains retrieval processing and so restricts what comes to mind as input to the attribution system. We review evidence that older adults, patients with Alzheimer's disease, and people with traumatic brain injury exert less cognitive control during retrieval, and so are susceptible to memory misattributions in the form of dramatic levels of false remembering.

Sign in / Sign up

Export Citation Format

Share Document