scholarly journals Higher Body Mass Index Is Associated with Lower Cortical Amyloid-β Burden in Cognitively Normal Individuals in Late-Life

2019 ◽  
Vol 69 (3) ◽  
pp. 817-827 ◽  
Author(s):  
Vineeth Thirunavu ◽  
Austin McCullough ◽  
Yi Su ◽  
Shaney Flores ◽  
Aylin Dincer ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Amyloid Β ◽  
Late Life ◽  
Cognitively Normal ◽  
Normal Individuals

Late-Life Obesity Associated with Tau Pathology in Cognitively Normal Individuals: The CABLE Study

2021 ◽  
pp. 1-11
Author(s):  
Xiao-Xue Zhang ◽  
Ya-Hui Ma ◽  
He-Ying Hu ◽  
Ling-Zhi Ma ◽  
Lan Tan ◽  
...  
Keyword(s):  
Central Obesity ◽  
Amyloid Β ◽  
Late Life ◽  
Inverse Association ◽  
Life Stages ◽  
Tau Pathology ◽  
Cognitively Normal ◽  
Normal Individuals ◽  
Obesity Indices ◽  
T Tau

Background: Existed evidence suggests that midlife obesity increases the risk of Alzheimer’s disease (AD), while there is an inverse association between AD and obesity in late life. However, the underlying metabolic changes of AD pathological proteins attributed to obesity in two life stages were not clear. Objective: To investigate the associations of obesity types and obesity indices with AD biomarkers in cerebrospinal fluid (CSF) in different life stages. Methods: We recruited 1,051 cognitively normal individuals (61.94±10.29 years, 59.66%male) from the Chinese Alzheimer’s Biomarker and LifestylE (CABLE) study with CSF detections for amyloid-β 42 (Aβ 42), total-tau (T-tau), and phosphorylated tau (P-tau). We utilized body mass index, waist circumference, waist-to-height ratio, and metabolic risk factors to determine human obesity types. Multiple linear models and interaction analyses were run to assess the impacts of obesity on AD biomarkers. Results: The metabolically unhealthy obesity or healthy obesity might exert a reduced tau pathology burden (p <  0.05). Individuals with overweight, general obesity, and central obesity presented lower levels of tau-related proteins in CSF than normal controls (p <  0.05). Specially, for late-life individuals, higher levels of obesity indices were associated with a lower load of tau pathology as measured by CSF T-tau and T-tau/Aβ 42 (p <  0.05). No similar significant associations were observed in midlife. Conclusion: Collectively, late-life general and central obesity seems to be associated with the reduced load of tau pathology, which further consolidates the favorable influence of obesity in specific life courses for AD prevention.

scholarly journals The dynamic association between body mass index and cognition from midlife through late-life, and the effect of sex and genetic influences

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ida K. Karlsson ◽  
Margaret Gatz ◽  
Thalida Em Arpawong ◽  
Anna K. Dahl Aslan ◽  
Chandra A. Reynolds
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Genetic Predisposition ◽  
Cognitive Abilities ◽  
Late Life ◽  
Change Score ◽  
Reciprocal Relationship ◽  
European Ancestry ◽  
Negative Effects ◽  
Dynamic Relationship

AbstractBody mass index (BMI) is associated with cognitive abilities, but the nature of the relationship remains largely unexplored. We aimed to investigate the bidirectional relationship from midlife through late-life, while considering sex differences and genetic predisposition to higher BMI. We used data from 23,892 individuals of European ancestry from the Health and Retirement Study, with longitudinal data on BMI and three established cognitive indices: mental status, episodic memory, and their sum, called total cognition. To investigate the dynamic relationship between BMI and cognitive abilities, we applied dual change score models of change from age 50 through 89, with a breakpoint at age 65 or 70. Models were further stratified by sex and genetic predisposition to higher BMI using tertiles of a polygenic score for BMI (PGSBMI). We demonstrated bidirectional effects between BMI and all three cognitive indices, with higher BMI contributing to steeper decline in cognitive abilities in both midlife and late-life, and higher cognitive abilities contributing to less decline in BMI in late-life. The effects of BMI on change in cognitive abilities were more evident in men compared to women, and among those in the lowest tertile of the PGSBMI compared to those in the highest tertile, while the effects of cognition on BMI were similar across groups. In conclusion, these findings highlight a reciprocal relationship between BMI and cognitive abilities, indicating that the negative effects of a higher BMI persist from midlife through late-life, and that weight-loss in late-life may be driven by cognitive decline.

scholarly journals Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease

2019 ◽  
Vol 15 (6) ◽  
pp. 764-775 ◽  
Author(s):  
Andrea Vergallo ◽  
Lucile Mégret ◽  
Simone Lista ◽  
Enrica Cavedo ◽  
Henrik Zetterberg ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Amyloid Β ◽  
Cognitively Normal ◽  
Cerebral Amyloidosis ◽  
Normal Individuals

Association Between Late-Life Body Mass Index, Waist Circumference, and Dementia: Kahrizak Elderly Study

2012 ◽  
Vol 60 (1) ◽  
pp. 173-174 ◽  
Author(s):  
Maryam Ghaderpanahi ◽  
Hossein Fakhrzadeh ◽  
Farshad Sharifi ◽  
Mojde Mirarefin ◽  
Zohre Badamchizade ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Waist Circumference ◽  
Body Mass ◽  
Late Life

scholarly journals Plasma amyloid β 42/40 ratios as biomarkers for amyloid β cerebral deposition in cognitively normal individuals

2017 ◽  
Vol 8 (1) ◽  
pp. 179-187 ◽  
Author(s):  
Noelia Fandos ◽  
Virginia Pérez‐Grijalba ◽  
Pedro Pesini ◽  
Salvador Olmos ◽  
Matías Bossa ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Cognitively Normal ◽  
Normal Individuals

scholarly journals GENETIC INFLUENCES ON BODY MASS INDEX ACROSS ADULTHOOD AND LATE-LIFE

2018 ◽  
Vol 2 (suppl_1) ◽  
pp. 620-620
Author(s):  
I K Karlsson ◽  
J Hallgren ◽  
N L Pedersen ◽  
C A Reynolds ◽  
A K Dahl Aslan
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Late Life ◽  
Genetic Influences
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