Reliability and Validity of the Chinese Version of the Mild Behavioral Impairment Checklist for Screening for Alzheimer’s Disease

2019 ◽  
Vol 70 (3) ◽  
pp. 747-756 ◽  
Author(s):  
Yue Cui ◽  
Sisi Dai ◽  
Zupei Miao ◽  
Yu Zhong ◽  
Yang Liu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Reliability And Validity ◽  
Chinese Version ◽  
Behavioral Impairment

Reliability and Validity of the Chinese Version of Mild Behavioral Impairment Checklist in Mild Cognitive Impairment and Mild Alzheimer’s Disease

2021 ◽  
pp. 1-9
Author(s):  
Lujie Xu ◽  
Tao Li ◽  
Lingchuan Xiong ◽  
Xiao Wang ◽  
Zahinoor Ismail ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Chinese Culture ◽  
Structural Reliability ◽  
Reliability And Validity ◽  
Chinese Version ◽  
Behavioral Impairment ◽  
Good Reliability

Background: Mild behavioral impairment (MBI) has been proposed as an early manifestation of dementia. The Mild Behavioral Impairment Checklist (MBI-C) may help identify MBI in prodromal and preclinical dementia. Objective: The study aimed to evaluate the reliability and validity of the Chinese version of MBI-C in mild cognitive impairment (MCI) and mild Alzheimer’s disease (AD), and to explore the structure of the five factors of the MBI-C in Chinese culture. Methods: Sixty dyads of MCI and mild AD (MCI, n = 33; mild AD, n = 35) were recruited. The informants completed the MBI-C and Neuropsychiatric Inventory Questionnaire (NPI-Q) and were interviewed for clinician rating of the NPI. The Cronbach’s coefficient was used to measure the structural reliability of the MBI-C. The criterion-validity was evaluated with the correlation coefficient between the MBI-C and the total scores of NPI-Q and NPI. Exploratory factor analysis was conducted to investigate the structure of the MBI-C. Results: The Cronbach’s α coefficient was 0.895. The MBI-C total score was positively correlated with all five domains (r = 0.577∼0.840). The total score of MBI-C was significantly correlated with the total scores of NPI-Q (r = 0.714) and NPI (r = 0.749). Similarly, the five domain scores of MBI-C were significantly correlated with the factor and total scores of NPI-Q (r = 0.312∼0.673) and NPI (r = 0.389∼0.673). The components of each factor in Chinese version of MBI-C were slightly different from those of the a priori defined domains (χ2 = 1818.202, df = 496, p < 0.001). Conclusion: The Chinese version of MBI-C has good reliability and validity, and can be used to evaluate the psychological and behavioral changes in MCI and mild AD.

Gaetano Perusini: The Forgotten Neuroscientist Behind “Alzheimer’s” Disease

2021 ◽  
pp. 107385842110594
Author(s):  
Francesco Pellegrini ◽  
Mattia Rosso ◽  
Duong T. Chu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorder ◽  
Behavioral Impairment ◽  
Near Future

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive and behavioral impairment with social and occupational impacts. This form of dementia is being increasingly studied, and its prevalence is expected to rise in the near future. Gaetano Perusini, a neuroscientist in the Alzheimer’s laboratory, has played a major clinical and pathological role in the earlier study of Alzheimer’s disease. This article summarizes his role in the discovery of the disease, which should be fairly named Alzheimer-Perusini disease.

scholarly journals Oral infections and orofacial pain in Alzheimer's disease: case report and review

2010 ◽  
Vol 4 (2) ◽  
pp. 145-150 ◽  
Author(s):  
Silvia Regina Dowgan T. de Siqueira ◽  
Thaís de Souza Rolim ◽  
Manoel Jacobsen Teixeira ◽  
Ricardo Nitrini ◽  
Renato Anghinah ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Facial Pain ◽  
Orofacial Pain ◽  
The Elderly ◽  
Secondary Headache ◽  
Behavioral Impairment ◽  
Common Cause ◽  
Oral Infections ◽  
Disease Case

Abstract Dental infections, frequent in the general population, are a common cause of inflammation with systemic impact, and are the most common cause of orofacial pain. Temporomandibular disorders are also frequent in the elderly and represent an important cause of secondary headache. Both inflammation and pain can also contribute to cognitive, functional and behavioral impairment of the elderly and aggravate symptoms of patients with Alzheimer's disease (AD). We report a case of a 74-year-old woman with AD and chronic facial pain who had a significant improvement in functional activities as well as in cognition and depressive symptoms after successful treatment of her facial pain. Patients with AD have higher compromise of oral health with infections and teeth loss. The investigation of orofacial pain should be performed in patients with AD, because of the associations reviewed and given the potential for improvement as highlighted by this case.

scholarly journals Mild behavioral impairment is associated with atrophy in Alzheimer's disease‐related regions in non‐demented older adults

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Veronika Matuskova ◽  
Zahinoor Ismail ◽  
Tomas Nikolai ◽  
Hana Markova ◽  
Katerina Cechova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Behavioral Impairment

Bacillus Subtilis Delays Neurodegeneration and Behavioral Impairment in the Alzheimer’s Disease Model Caenorhabditis Elegans

2020 ◽  
Vol 73 (3) ◽  
pp. 1035-1052 ◽  
Author(s):  
Sebastián Cogliati ◽  
Victoria Clementi ◽  
Marcos Francisco ◽  
Cira Crespo ◽  
Federico Argañaraz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Bacillus Subtilis ◽  
Caenorhabditis Elegans ◽  
Disease Model ◽  
Behavioral Impairment

Behavioral Disorders and Caregivers' Reaction in Taiwanese Patients With Alzheimer's Disease

2001 ◽  
Vol 13 (1) ◽  
pp. 121-128 ◽  
Author(s):  
Jong-Ling Fuh ◽  
Ching-Kuan Liu ◽  
Michael S. Mega ◽  
Shuu-Jiun Wang ◽  
Jeffrey L. Cummings
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Motor Activity ◽  
Social Engagement ◽  
Motor Behavior ◽  
Chinese Version ◽  
Caregiver Distress ◽  
Distress Score ◽  
Neuropsychiatric Manifestations ◽  
Test Retest Reliability

Objectives: To evaluate the applicability of the Chinese version of the Neuropsychiatric Inventory Scale (NPI), and to explore the neuropsychiatric manifestations of Taiwanese patients with Alzheimer's disease (AD) and caregiver distress. Method: The Mini-Mental State Examination (MMSE) was administered to 95 patients with AD, and their caregivers were interviewed with the NPI. To assess the test-retest reliability of the Chinese version of the NPI, 86 caregivers underwent a second NPI 3 weeks later. Results: The Cronbach's alpha coefficient of the Chinese version of the NPI was .76. The test-rest reliabilities of frequency, severity, and caregiver burden scores were significantly correlated; overall correlations were .85 for frequency (p < .001), .82 for severity (p < .001), and .79 (p < .001) for distress. Factor analysis was carried out, and three groups, “mood and psychosis,” “psychomotor regulation,” and “social engagement,” were found. Aberrant motor behavior was the most frequently recorded behavior; euphoria was the least. There was no significant correlation between the patient's MMSE and the caregiver distress score, except for aberrant motor activity (r = −.23, p = .03). The symptoms most frequently reported to be severely distressing to caregivers were aberrant motor activity, anxiety, agitation, and delusions. Conclusions: These results indicate that the NPI is a reliable tool to assess behavioral disturbance and caregiver distress in Taiwanese AD patients. These findings also confirm the high prevalence of psychopathology among AD patients and the marked distress produced by many of these behaviors.

Reliability and Validity of the Tinkertoy Test in Evaluating Individuals with Alzheimer's Disease

1998 ◽  
Vol 12 (3) ◽  
pp. 325-329 ◽  
Author(s):  
Elisabeth Koss ◽  
Marian B. Patterson ◽  
James L. Mack ◽  
Kathleen A. Smyth ◽  
Peter J. Whitehouse
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Reliability And Validity
Sign in / Sign up

Export Citation Format

Share Document