scholarly journals Population-Based Approaches to Dementia Prevention

2019 ◽  
Vol 70 (s1) ◽  
pp. S15-S17 ◽  
Author(s):  
Claire E. Sexton ◽  
Kristine Yaffe
Keyword(s):  
Population Based ◽  
Dementia Prevention

scholarly journals Independent and joint effects of vascular and cardiometabolic risk factor pairs for risk of all-cause dementia: a prospective population-based study

2019 ◽  
Vol 31 (10) ◽  
pp. 1421-1432 ◽  
Author(s):  
C. Elizabeth Shaaban ◽  
Yichen Jia ◽  
Chung-Chou H. Chang ◽  
Mary Ganguli
Keyword(s):  
Cardiometabolic Risk ◽  
Joint Effect ◽  
Population Based ◽  
Cox Models ◽  
Joint Effects ◽  
Synergistic Interactions ◽  
Dementia Risk ◽  
Dementia Prevention ◽  
Adjusted Model

ABSTRACTObjectives:To assess independent and joint effects of pairs of vascular and cardiometabolic risk factors (VCMRFs) in relation to risk of all-cause dementia.Design:Population-based longitudinal cohort study of cognitive impairment. We used an algorithm to select pairs of VCMRFs and tested their joint effects in time-dependent Cox models. We used attributable proportions (AP) to measure the proportion of risk from interactions beyond any additive effect.Setting:Economically depressed small-town population.Participants:Adults age 65+ years with up to 10 yearly study visits (N=1701, median (Q1, Q3) age, 78 (71.0, 83.0), 62.3% female, 94.9% white).Results:Among 1701 participants free from prevalent dementia with at least one follow-up visit, 109 developed incident all-cause dementia. In pairings of APOE*4 with hypertension (HTN) and congestive heart failure (CHF), the variables contributed independently and additively to all-cause dementia risk. In pairings of APOE*4 with stroke and stroke with CHF, the variables demonstrated independent contributions to all-cause dementia risk; their joint effects showed excess detriment demonstrating synergistic interactions (joint HR [95% CI]: 28.33 [6.74, 119.01] and 50.30 [14.57, 173.57] respectively, fully adjusted models). Physical activity (PA) was independently associated with lower all-cause dementia risk when paired with APOE*4, stroke, and CHF in unadjusted models; these associations did not survive covariate adjustment. The joint effect of low PA and APOE*4 was associated with additively increased all-cause dementia risk (joint HR [95% CI]: 4.61 [2.07, 10.23], fully adjusted model).Conclusions:Reduction of VCMRFs, including low PA, could be valuable for dementia prevention, especially among APOE*4 carriers.

P2-104: Statins and dementia prevention: A population-based study (FINRISK)

2009 ◽  
Vol 5 (4S_Part_10) ◽  
pp. P292-P292 ◽  
Author(s):  
Alina Solomon ◽  
Hilkka Soininen ◽  
Tiina Laatikainen ◽  
Jaakko Tuomilehto ◽  
Miia Kivipelto
Keyword(s):  
Population Based ◽  
Population Based Study ◽  
Dementia Prevention

scholarly journals PRIMARY PREVENTION OF DEMENTIA: THE FUTURE OF POPULATION-BASED MULTIDOMAIN LIFESTYLE INTERVENTIONS

2017 ◽  
pp. 1-3
Author(s):  
Y. Lee
Keyword(s):  
Risk Factors ◽  
Physical Inactivity ◽  
Health Impact ◽  
Population Based ◽  
Preventive Strategies ◽  
Dementia Prevalence ◽  
Dementia Prevention ◽  
Low Education ◽  
Disease Modifying ◽  
Potential Public Health

Dementia affects 46.8 million of the world’s population, and is projected to increase to 131.5 million by 2050 (1). Increasingly, with no available disease-modifying drug or cure for the disease, preventive strategies are being pursued to curb the worldwide epidemic. Accumulating evidence supports the importance of dementia prevention, with seven risk factors (diabetes mellitus, midlife obesity, midlife hypertension, physical inactivity, depression, smoking, and low education) estimated to contribute to 9.6 million cases, equivalent to a third of Alzheimer’s disease worldwide (2). The potential public health impact of prevention is huge as a 20% reduction per decade from 2010 in the prevalence of these risk factors would translate to a 16.3% (1.5 million) reduction in dementia prevalence by 2050.

scholarly journals Risk of Incident Dementia According to Glycemic Status and Comorbidities of Hyperglycemia: A Nationwide Population-Based Cohort Study

2021 ◽  
Author(s):  
Woo Jung Kim ◽  
Seo Jung Lee ◽  
Eun Lee ◽  
Eun Young Lee ◽  
Kyungdo Han
Keyword(s):  
Fasting Glucose ◽  
Population Based ◽  
Glycemic Status ◽  
Glucose Levels ◽  
Onset Diabetes ◽  
Hazard Ratios ◽  
Incident Dementia ◽  
Dementia Prevention ◽  
Design And Methods ◽  
New Onset

Objective: To investigate the risk of incident dementia according to fasting glucose levels and presence of comorbidities. <p>Research Design and Methods:<b> </b>Using a health insurance claims database and the results of biennial health examinations in South Korea, we selected 8,400,950 subjects aged ≥40 years who underwent health examinations in 2009–2010. We followed them until 2016. Subjects’ baseline characteristics were categorized by presence of diabetes (yes/no) and glycemic status (normoglycemia/impaired fasting glucose (IFG)/new-onset diabetes/known diabetes (duration <5 years or ≥5 years). We estimated adjusted hazard ratios (aHRs) for dementia occurrence in each category. </p> <p>Results: During the observation period of 48,323,729 person-years, all-cause dementia developed in 353,392 (4.2%) subjects. Compared with normoglycemia, aHRs (95% confidence interval) were 1.01 (1.01–1.02) in IFG, 1.45 (1.44–1.47) in new-onset diabetes, 1.32 (1.30–1.33) in known diabetes <5 years, and 1.62 (1.60–1.64) in known diabetes ≥5 years. We found that associations between ischemic heart disease and chronic kidney disease with incident dementia were affected by the presence of diabetes. Ischemic stroke showed a greater association with incident dementia than diabetes. </p> Conclusions:<b> </b>Mild degrees of hyperglycemia and presence of comorbidities were associated with incident dementia. Intervention during the prodromal stage of a chronic disease (e.g., prediabetes) could be considered for dementia prevention.

LETTER TO THE EDITOR: PREVENTING DEMENTIA THROUGH COMMUNITY INVOLVEMENT AND ALTRUISTIC BEHAVIORS

2018 ◽  
pp. 1-2
Author(s):  
Y. Maki
Keyword(s):  
Standardized Tests ◽  
Community Involvement ◽  
Cognitive Functions ◽  
Memory Function ◽  
Population Based ◽  
Social Involvement ◽  
Cognitive Tests ◽  
Social Settings ◽  
Dementia Prevention ◽  
Cooperative Behaviors

Population-based studies on dementia prevention have focused on exercise, nutrition, and maintaining social involvement and the effectiveness of these interventions has been determined based on cognitive functions assessed using standardized tests, such as memory function (1, 2). However, the question arises whether all human cognitive functions can be measured with standardized cognitive tests alone. The human brain is assumed to have evolved for cooperation in social settings, and altruistic behaviors and cooperative behaviors have been found mostly in humans. Thus social cognition, which is difficult to be measured with standardized cognitive tests, can be the essence of human cognitive function.

Exercise Types and the Risk of Developing Cognitive Decline in Older Women: A Prospective Study

2020 ◽  
Vol 77 (4) ◽  
pp. 1733-1742
Author(s):  
Yosuke Osuka ◽  
Narumi Kojima ◽  
Hiroyuki Sasai ◽  
Yuki Ohara ◽  
Yutaka Watanabe ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Older Women ◽  
Mmse Score ◽  
Population Based ◽  
Japanese Women ◽  
Community Dwelling ◽  
Baseline Survey ◽  
Specific Exercise ◽  
Dementia Prevention

Background: Participation in exercise may be useful for dementia prevention; however, the specific exercise types which may best to reduce the risk of developing cognitive decline have remained unidentified in the literature. Objective: To examine the relationships of specific exercise types with the risk of developing cognitive decline in older women. Methods: This 1- to 2-year population-based cohort study included 687 community-dwelling older Japanese women without disability, neurological disease, dementia, or cognitive impairment assessed as <24 points on the Mini-Mental State Examination (MMSE) at the baseline survey. Developing cognitive decline was defined as a decrease of ≥3 points in the participant’s MMSE score during the follow-up. We classified individuals into participation (≥3 months) and non-participation (<3 months) groups for 17 different exercise types. Log-binominal regression analyses were applied to compare risk ratios and confidence intervals of developing cognitive decline between the two groups. Results: Thirty-nine participants (5.7%) developed cognitive decline during the follow-up period. After adjusting for confounders (age, MMSE score, depressive symptoms, body mass index, heart disease, hypertension, diabetes, smoking, low educational level, and the follow-up period in the baseline survey), those who participated in calisthenics demonstrated a significantly lower risk of developing cognitive decline than those who did not participate in calisthenics. No significant relationships between other exercise types and the risk of developing cognitive decline were found. Conclusion: Participation in calisthenics significantly reduced the risk of cognitive decline in community-dwelling older Japanese women, indicating that calisthenics may be a useful type of exercise for promoting dementia prevention.

Risk of fracture in Crohn's disease: A population-based study

2001 ◽  
Vol 120 (5) ◽  
pp. A628-A628
Author(s):  
E LOFTUSJR ◽  
C CROWSON ◽  
W SANDBORN ◽  
W TREAMINE ◽  
W OFALLON ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Population Based ◽  
Population Based Study ◽  
Risk Of Fracture
Sign in / Sign up

Export Citation Format

Share Document