Impact of Social Frailty on Alzheimer’s Disease Onset: A 53-Month Longitudinal Cohort Study

2019 ◽  
Vol 70 (2) ◽  
pp. 587-595 ◽  
Author(s):  
Kota Tsutsumimoto ◽  
Takehiko Doi ◽  
Sho Nakakubo ◽  
Minji Kim ◽  
Satoshi Kurita ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cohort Study ◽  
Disease Onset ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort

scholarly journals Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study

2013 ◽  
Vol 12 (10) ◽  
pp. 957-965 ◽  
Author(s):  
Stephanie JB Vos ◽  
Chengjie Xiong ◽  
Pieter Jelle Visser ◽  
Mateusz S Jasielec ◽  
Jason Hassenstab ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cohort Study ◽  
Longitudinal Cohort Study ◽  
Preclinical Alzheimer’S Disease ◽  
Longitudinal Cohort

scholarly journals European Prevention of Alzheimer’s Dementia Longitudinal Cohort Study (EPAD LCS): study protocol

BMJ Open ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. e021017 ◽  
Author(s):  
Alina Solomon ◽  
Miia Kivipelto ◽  
José Luis Molinuevo ◽  
Brian Tom ◽  
Craig W Ritchie
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cohort Study ◽  
Alzheimer’S Dementia ◽  
Longitudinal Cohort Study ◽  
Community Research ◽  
Data Set ◽  
Alzheimer's Dementia ◽  
Longitudinal Cohort ◽  
Research Participants

IntroductionThe European Prevention of Alzheimer’s Dementia (EPAD) project is funded initially by the Innovative Medicines Initiative and has been established to overcome the major hurdles hampering drug development for secondary prevention of Alzheimer’s dementia, by conducting the EPAD Longitudinal Cohort Study (LCS) in alignment with the Bayesian adaptive designed EPAD Proof-of-Concept (PoC) trial.Methods and analysisEPAD LCS is an ongoing prospective, multicentre, pan-European longitudinal cohort study. Participants are recruited mainly from existing parent cohorts across Europe to form a ‘probability-spectrum’ population covering the entire continuum of anticipated probability for Alzheimer’s dementia development. The primary objective of the EPAD LCS is to be a readiness cohort for the EPAD PoC trial though a second major objective is to generate a comprehensive and large data set for disease modelling of preclinical and prodromal Alzheimer’s disease. This characterisation of cognitive, biomarker and risk factor (genetic and environmental) status of research participants over time will provide the necessary well-phenotyped population for developing accurate longitudinal models for Alzheimer’s disease covering the entire disease course and concurrently create a pool of highly characterised individuals for the EPAD PoC trial.Ethics and disseminationThe study has received the relevant approvals from numerous Institutional Review Boards across Europe. Findings will be disseminated to several target audiences, including the scientific community, research participants, patient community, general public, industry, regulatory authorities and policy-makers. Regular and coordinated releases of EPAD LCS data will be made available for analysis to help researchers improve their understanding of early Alzheimer’s disease stages and facilitate collaborations.Trial registration numberNCT02804789.

Brain size and the compensation of Alzheimer's disease symptoms: A longitudinal cohort study

2012 ◽  
Vol 9 (5) ◽  
pp. 580-586 ◽  
Author(s):  
Liang-Hao Guo ◽  
Panagiotis Alexopoulos ◽  
Stefan Wagenpfeil ◽  
Alexander Kurz ◽  
Robert Perneczky ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cohort Study ◽  
Brain Size ◽  
Longitudinal Cohort Study ◽  
Disease Symptoms ◽  
Longitudinal Cohort

Memory Correlates of Alzheimer’s Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study

2017 ◽  
Vol 60 (3) ◽  
pp. 1119-1128 ◽  
Author(s):  
Babette L.R. Reijs ◽  
Inez H.G.B. Ramakers ◽  
Sebastian Köhler ◽  
Charlotte E. Teunissen ◽  
Marleen Koel-Simmelink ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Cohort Study ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort
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