scholarly journals The role of Alzheimer’s disease polygenic risk scores in changes of cognitive function in older adults: A longitudinal cohort study

2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Gongbu Pan ◽  
Anna E. King ◽  
Aidan Bindoff ◽  
Mathew J. Summers ◽  
James C. Vickers ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Cohort Study ◽  
Cognitive Function ◽  
Longitudinal Cohort Study ◽  
Risk Scores ◽  
Longitudinal Cohort ◽  
Polygenic Risk

scholarly journals Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study

2013 ◽  
Vol 12 (10) ◽  
pp. 957-965 ◽  
Author(s):  
Stephanie JB Vos ◽  
Chengjie Xiong ◽  
Pieter Jelle Visser ◽  
Mateusz S Jasielec ◽  
Jason Hassenstab ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cohort Study ◽  
Longitudinal Cohort Study ◽  
Preclinical Alzheimer’S Disease ◽  
Longitudinal Cohort

scholarly journals European Prevention of Alzheimer’s Dementia Longitudinal Cohort Study (EPAD LCS): study protocol

BMJ Open ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. e021017 ◽  
Author(s):  
Alina Solomon ◽  
Miia Kivipelto ◽  
José Luis Molinuevo ◽  
Brian Tom ◽  
Craig W Ritchie
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cohort Study ◽  
Alzheimer’S Dementia ◽  
Longitudinal Cohort Study ◽  
Community Research ◽  
Data Set ◽  
Alzheimer's Dementia ◽  
Longitudinal Cohort ◽  
Research Participants

IntroductionThe European Prevention of Alzheimer’s Dementia (EPAD) project is funded initially by the Innovative Medicines Initiative and has been established to overcome the major hurdles hampering drug development for secondary prevention of Alzheimer’s dementia, by conducting the EPAD Longitudinal Cohort Study (LCS) in alignment with the Bayesian adaptive designed EPAD Proof-of-Concept (PoC) trial.Methods and analysisEPAD LCS is an ongoing prospective, multicentre, pan-European longitudinal cohort study. Participants are recruited mainly from existing parent cohorts across Europe to form a ‘probability-spectrum’ population covering the entire continuum of anticipated probability for Alzheimer’s dementia development. The primary objective of the EPAD LCS is to be a readiness cohort for the EPAD PoC trial though a second major objective is to generate a comprehensive and large data set for disease modelling of preclinical and prodromal Alzheimer’s disease. This characterisation of cognitive, biomarker and risk factor (genetic and environmental) status of research participants over time will provide the necessary well-phenotyped population for developing accurate longitudinal models for Alzheimer’s disease covering the entire disease course and concurrently create a pool of highly characterised individuals for the EPAD PoC trial.Ethics and disseminationThe study has received the relevant approvals from numerous Institutional Review Boards across Europe. Findings will be disseminated to several target audiences, including the scientific community, research participants, patient community, general public, industry, regulatory authorities and policy-makers. Regular and coordinated releases of EPAD LCS data will be made available for analysis to help researchers improve their understanding of early Alzheimer’s disease stages and facilitate collaborations.Trial registration numberNCT02804789.

Impact of Social Frailty on Alzheimer’s Disease Onset: A 53-Month Longitudinal Cohort Study

2019 ◽  
Vol 70 (2) ◽  
pp. 587-595 ◽  
Author(s):  
Kota Tsutsumimoto ◽  
Takehiko Doi ◽  
Sho Nakakubo ◽  
Minji Kim ◽  
Satoshi Kurita ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cohort Study ◽  
Disease Onset ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort

scholarly journals Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer’s Disease

2016 ◽  
Vol 55 (2) ◽  
pp. 473-484 ◽  
Author(s):  
Burcu F. Darst ◽  
Rebecca L. Koscik ◽  
Annie M. Racine ◽  
Jennifer M. Oh ◽  
Rachel A. Krause ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Function ◽  
Amyloid Β ◽  
Risk Scores ◽  
Polygenic Risk ◽  
Increased Risk
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