Comparative Utility of Manual versus Automated Segmentation of Hippocampus and Entorhinal Cortex Volumes in a Memory Clinic Sample

2019 ◽  
Vol 68 (1) ◽  
pp. 159-171 ◽  
Author(s):  
Yi Leng Fung ◽  
Kelly E.T. Ng ◽  
Simon J. Vogrin ◽  
Catherine Meade ◽  
Michael Ngo ◽  
...  
Keyword(s):  
Entorhinal Cortex ◽  
Automated Segmentation ◽  
Memory Clinic ◽  
Clinic Sample

scholarly journals Classification accuracy of the English version of the Canadian Indigenous Cognitive Assessment (CICA) in a majority culture memory clinic sample

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Megan E. O'Connell ◽  
Jennifer D. Walker ◽  
Kristen Jacklin ◽  
Carrie Ann Bourassa ◽  
Andrew Kirk ◽  
...  
Keyword(s):  
Classification Accuracy ◽  
Cognitive Assessment ◽  
Memory Clinic ◽  
English Version ◽  
Clinic Sample ◽  
Majority Culture

scholarly journals Mild Behavioral Impairment Is Associated With Atrophy of Entorhinal Cortex and Hippocampus in a Memory Clinic Cohort

2021 ◽  
Vol 13 ◽  
Author(s):  
Veronika Matuskova ◽  
Zahinoor Ismail ◽  
Tomas Nikolai ◽  
Hana Markova ◽  
Katerina Cechova ◽  
...  
Keyword(s):  
Older Adults ◽  
Entorhinal Cortex ◽  
Brain Aging ◽  
Neuropsychiatric Symptoms ◽  
Brain Magnetic Resonance Imaging ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Subjective Cognitive Decline ◽  
Memory Clinic ◽  
Behavioral Impairment

ObjectivesMild behavioral impairment (MBI) is a syndrome describing late-onset persistent neuropsychiatric symptoms (NPS) in non-demented older adults. Few studies to date have investigated the associations of MBI with structural brain changes. Our aim was to explore structural correlates of NPS in a non-demented memory clinic sample using the Mild Behavioral Impairment Checklist (MBI-C) that has been developed to measure MBI.MethodsOne hundred sixteen non-demented older adults from the Czech Brain Aging Study with subjective cognitive concerns were classified as subjective cognitive decline (n = 37) or mild cognitive impairment (n = 79). Participants underwent neurological and neuropsychological examinations and brain magnetic resonance imaging (MRI) (1.5 T). The Czech version of the MBI-C was administered to participants’ informants. Five a priori selected brain regions were measured, namely, thicknesses of the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and entorhinal cortex (ERC) and volume of the hippocampus (HV), and correlated with MBI-C total and domain scores.ResultsEntorhinal cortex was associated with MBI-C total score (rS = −0.368, p < 0.001) and with impulse dyscontrol score (rS = −0.284, p = 0.002). HV was associated with decreased motivation (rS = −0.248, p = 0.008) and impulse dyscontrol score (rS = −0.240, p = 0.011).ConclusionNeuropsychiatric symptoms, particularly in the MBI impulse dyscontrol and motivation domains, are associated with medial temporal lobe atrophy in a clinical cohort of non-demented older adults. This study supports earlier involvement of temporal rather than frontal regions in NPS manifestation. Since these regions are typically affected early in the course of Alzheimer’s disease (AD), the MBI-C may potentially help further identify individuals at-risk of developing AD dementia.

scholarly journals Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
C. Eckerström ◽  
J. Svensson ◽  
P. Kettunen ◽  
M. Jonsson ◽  
M. Eckerström
Keyword(s):  
Memory Clinic ◽  
Clinic Sample

scholarly journals Intraindividual variability measured with dispersion across diagnostic groups in a memory clinic sample

2021 ◽  
pp. 1-10
Author(s):  
Karl S. Grewal ◽  
Megan E. O’Connell ◽  
Andrew Kirk ◽  
Stuart W. S. MacDonald ◽  
Debra Morgan
Keyword(s):  
Intraindividual Variability ◽  
Memory Clinic ◽  
Clinic Sample

scholarly journals Neuropsychiatric correlates of cerebral amyloid burden in a memory clinic sample

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Cheuk Ni Kan ◽  
Liwen Zhang ◽  
Anthonin Reilhac ◽  
Saima Hilal ◽  
Bibek Gyanwali ◽  
...  
Keyword(s):  
Amyloid Burden ◽  
Memory Clinic ◽  
Clinic Sample ◽  
Cerebral Amyloid

scholarly journals Associations of increased interstitial fluid with vascular and neurodegenerative abnormalities in a memory clinic sample

2021 ◽  
Author(s):  
Merel M. van der Thiel ◽  
Whitney M. Freeze ◽  
Inge C.M. Verheggen ◽  
Sau May Wong ◽  
Joost J.A. de Jong ◽  
...  
Keyword(s):  
Interstitial Fluid ◽  
Memory Clinic ◽  
Clinic Sample
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