scholarly journals Neuropsychiatric correlates of cerebral amyloid burden in a memory clinic sample

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Cheuk Ni Kan ◽  
Liwen Zhang ◽  
Anthonin Reilhac ◽  
Saima Hilal ◽  
Bibek Gyanwali ◽  
...  
Keyword(s):  
Amyloid Burden ◽  
Memory Clinic ◽  
Clinic Sample ◽  
Cerebral Amyloid

Abstract P59: Peak Width of Skeletonized Mean Diffusivity Outperforms Other Diffusion Tensor Imaging Metrics as Biomarker for Cognition in Memory-Clinic Subjects With Cerebral Amyloid Angiopathy

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Maria Clara Zanon Zotin ◽  
Dorothee Schoemaker ◽  
Valentina Perosa ◽  
Martin Bretzner ◽  
Lukas Sveikata ◽  
...  
Keyword(s):  
Executive Function ◽  
Diffusion Tensor Imaging ◽  
Linear Regression ◽  
Processing Speed ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Amyloid Angiopathy ◽  
Peak Width ◽  
Memory Clinic ◽  
Cerebral Amyloid

Introduction: Peak width of skeletonized mean diffusivity (PSMD) is a novel fully automated diffusion tensor imaging (DTI) marker that has been consistently associated with cognition in cerebral small vessel disease (SVD) cohorts, including cerebral amyloid angiopathy (CAA). We hypothesized that PSMD would be more strongly associated with cognitive performance compared to other conventional DTI metrics in our CAA sample. Methods: We recruited non-demented subjects with probable-CAA from a single-center memory-clinic cohort. We analyzed structural MRIs to compute a validated CAA burden score (0-6 points scale, based on the following MRI features: lobar microbleeds, superficial siderosis, perivascular spaces in centrum semiovale, and white matter hyperintensities). PSMD was obtained using a freely available script ( www.psmd-marker.com ). We used the same skeleton-mask to compute: mean of skeletonized mean diffusivity (mean MD) and mean of skeletonized fractional anisotropy (mean FA). We used linear regression analyses to explore relationships with CAA burden score and cognitive composite scores (processing speed, executive function, memory, and language - z-scores adjusted for age, sex and education level). Results: We included 43 subjects (mean age 74.4 ± 5.9 years; 48.8% female; PSMD median [IQR]: 4.05 [3.58 - 4.80] x 10 -4 mm 2 /s). In linear regression models adjusting for age, DTI metrics were significantly associated with CAA burden score (mean FA: β = -0.563, Adj. R 2 : 0.27; p < 0.001; mean MD: β = 0.581; Adj. R 2 : 0.32; p < 0.001; PSMD: β = 0.364, Adj. R 2 : 0.12; p = 0.018). PSMD was significantly associated with cognitive performance, specifically in the domains of executive function ( β = -0.568; Adj. R 2 : 0.25; p < 0.001) and processing speed ( β = -0.447; Adj. R 2 : 0.19; p = 0.004). Other DTI metrics were not significantly associated with cognitive scores. Conclusion: In this CAA sample, all DTI metrics were associated with CAA burden scores, however, only PSMD was significantly associated with cognition, in domains that are commonly affected in vascular cognitive impairment. Our results warrant confirmation in larger samples, but support PSMD as biomarker for cognition in CAA, outperforming other conventional DTI metrics.

scholarly journals Prediction of Cerebral Amyloid With Common Information Obtained From Memory Clinic Practice

2018 ◽  
Vol 10 ◽  
Author(s):  
Jun Ho Lee ◽  
Min Soo Byun ◽  
Dahyun Yi ◽  
Bo Kyung Sohn ◽  
So Yeon Jeon ◽  
...  
Keyword(s):  
Memory Clinic ◽  
Common Information ◽  
Cerebral Amyloid ◽  
Clinic Practice

scholarly journals Classification accuracy of the English version of the Canadian Indigenous Cognitive Assessment (CICA) in a majority culture memory clinic sample

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Megan E. O'Connell ◽  
Jennifer D. Walker ◽  
Kristen Jacklin ◽  
Carrie Ann Bourassa ◽  
Andrew Kirk ◽  
...  
Keyword(s):  
Classification Accuracy ◽  
Cognitive Assessment ◽  
Memory Clinic ◽  
English Version ◽  
Clinic Sample ◽  
Majority Culture

Imaging of amyloid burden and distribution in cerebral amyloid angiopathy

2007 ◽  
Vol 62 (3) ◽  
pp. 229-234 ◽  
Author(s):  
Keith A. Johnson ◽  
Matt Gregas ◽  
John A. Becker ◽  
Catherine Kinnecom ◽  
David H. Salat ◽  
...  
Keyword(s):  
Cerebral Amyloid Angiopathy ◽  
Amyloid Angiopathy ◽  
Amyloid Burden ◽  
Cerebral Amyloid

Nasal administration of amyloid-? peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease

2000 ◽  
Vol 48 (4) ◽  
pp. 567-579 ◽  
Author(s):  
Howard L. Weiner ◽  
Cynthia A. Lemere ◽  
Ruth Maron ◽  
Edward T. Spooner ◽  
Trelawney J. Grenfell ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Amyloid Peptide ◽  
Nasal Administration ◽  
Amyloid Burden ◽  
Model Of Alzheimer’S Disease ◽  
Cerebral Amyloid

IC-P-028: Sleep Quality in Young and Middle Age-Period is Associated With Cerebral Amyloid Burden in Cognitively Normal Elderly People

2016 ◽  
Vol 12 ◽  
pp. P29-P29
Author(s):  
Young Min Choe ◽  
Min Soo Byun ◽  
Dahyun Yi ◽  
Hyo Jung Choi ◽  
Hyewon Baek ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Elderly People ◽  
Middle Age ◽  
Amyloid Burden ◽  
Cognitively Normal ◽  
Cerebral Amyloid
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