PCSK9 Promotes oxLDL-Induced PC12 Cell Apoptosis Through the Bcl-2/Bax-Caspase 9/3 Signaling Pathway

2017 ◽  
Vol 57 (3) ◽  
pp. 723-734 ◽  
Author(s):  
Lu-Shan Liu ◽  
Xue-Qin Bai ◽  
Ya Gao ◽  
Qi Wu ◽  
Zhong Ren ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Pc12 Cell ◽  
Cell Apoptosis ◽  
Caspase 9

scholarly journals Rana catesbeiana ribonuclease induces cell apoptosis via the caspase-9/-3 signaling pathway in human glioblastoma DBTRG, GBM8901 and GBM8401 cell lines

2015 ◽  
Vol 9 (6) ◽  
pp. 2471-2476 ◽  
Author(s):  
JEN-NI CHEN ◽  
GIOU-TENG YIANG ◽  
YI-FAN LIN ◽  
PEI-LUN CHOU ◽  
TSAI-KUN WU ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Cell Lines ◽  
Cell Apoptosis ◽  
Rana Catesbeiana ◽  
Caspase 9 ◽  
Human Glioblastoma

Bmp4 inhibits goose granulosa cell apoptosis via PI3K/AKT/Caspase-9 signaling pathway

2019 ◽  
Vol 200 ◽  
pp. 86-95 ◽  
Author(s):  
Junsong Yuan ◽  
Yan Deng ◽  
Yingying Zhang ◽  
Xiang Gan ◽  
Shanyan Gao ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Granulosa Cell ◽  
Cell Apoptosis ◽  
Caspase 9

Protective effect of hydrogen against ischemia-reperfusion induced spinal nerve cell apoptosis

2021 ◽  
Author(s):  
Yanqing Sun ◽  
Wei Shi ◽  
Bo Yuan ◽  
Zhiwei Wang ◽  
Shengyuan Zhou ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Protective Effect ◽  
Cell Viability ◽  
Signaling Pathway ◽  
Pc12 Cells ◽  
Pc12 Cell ◽  
Cell Apoptosis ◽  
Caspase 3 ◽  
Ischemia Reperfusion ◽  
Caspase 12

Abstract Background: This study aims to explore the protective effect of hydrogen against oxygen-glucose-serum deprivation/restoration (OGSD/R)-induced PC12 cell apoptosis in vitro and the possible underlying mechanism. Methods: A normal control (NC) group was set where PC12 cells were cultured normal, while a positive control (PC) group, where PC12 cells were exposed to OGSD 12h/R1h without intervention, and a hydrogen intervention (HI) group, where PC12 cells were exposed to OGSD 12h/R1h plus HI, were conducted at the same time. At OGSD 12h/R 1h, cells were DAPI stained to detect viability and changes in the expression of apoptosis-associated proteins caspase-3, caspase-12 and CHOP/GADD153, and the endoplasmic reticulum-related signaling pathway protein PERK-eIF2α-ATF4. At the same time, the effect of HI was observed. Results: The result revealed that compared with NC group, cell apoptosis was more severe and cell viability was reduced significantly in PC group, while cell apoptosis was ameliorated and cell viability was increased significantly in HI as compared with PC group. In addition, the content of caspase-3 and caspase-12 in HI group was decreased significantly as compared with that in PC group. During this process, the endoplasmic reticulum-related signaling pathway protein PERK-eIF2α-ATF4 was activated. In HI group, the expression of this protein was decreased and cell viability was increased significantly as compared with those in PC group. Conclusions: Hydrogen was able to inhibit OGSD/R-induced PC12 cell apoptosis and exert a protective effect against ischemia-repurfusion injury (IRI) to nerve cells, probably through inhibiting the endoplasmic reticulum-related signaling pathway protein.

scholarly journals DHA ameliorates MeHg‑induced PC12 cell apoptosis by inhibiting the ROS/JNK signaling pathway

2021 ◽  
Vol 24 (2) ◽  
Author(s):  
Hong Zhang ◽  
Susu Wang ◽  
Yaqian Wang ◽  
Anxin Lu ◽  
Chunping Hu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Pc12 Cell ◽  
Cell Apoptosis ◽  
Jnk Signaling ◽  
Jnk Signaling Pathway

scholarly journals Role of Notch-1 signaling pathway in PC12 cell apoptosis induced by amyloid beta-peptide (25-35)

2014 ◽  
Vol 9 (13) ◽  
pp. 1297 ◽  
Author(s):  
Huimin Liang ◽  
Jiyu Lou ◽  
Yaozhou Zhang ◽  
Xiaoyan Shi ◽  
Tianxiang Wei
Keyword(s):  
Signaling Pathway ◽  
Amyloid Beta ◽  
Pc12 Cell ◽  
Cell Apoptosis ◽  
Amyloid Beta Peptide ◽  
Notch 1 ◽  
Beta Peptide

Role of Bm30kc6 gene in cell apoptosis and the silk gland degradation signaling pathway in Bombyx mori L.

2020 ◽  
Vol 105 (3) ◽  
Author(s):  
Ying Xiao ◽  
Lei‐lei Li ◽  
Asma Bibi ◽  
Ning Zhang ◽  
Ting Chen ◽  
...  
Keyword(s):  
Bombyx Mori ◽  
Signaling Pathway ◽  
Cell Apoptosis ◽  
Silk Gland ◽  
Bombyx Mori L

scholarly journals Retraction: Salvianolic acid B inhibits inflammatory response and cell apoptosis via the PI3K/Akt signaling pathway in IL-1β-induced osteoarthritis chondrocytes

RSC Advances ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 4441-4441
Author(s):  
Laura Fisher
Keyword(s):  
Inflammatory Response ◽  
Signaling Pathway ◽  
Cell Apoptosis ◽  
Akt Signaling ◽  
Salvianolic Acid B ◽  
Signalling Pathway ◽  
Akt Signaling Pathway ◽  
Salvianolic Acid ◽  
Osteoarthritis Chondrocytes

Retraction of ‘Salvianolic acid B inhibits inflammatory response and cell apoptosis via the PI3K/Akt signalling pathway in IL-1β-induced osteoarthritis chondrocytes’ by Bin Zhu et al., RSC Adv., 2018, 8, 36422–36429, DOI: 10.1039/C8RA02418A.

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