Episodic Memory Dysfunction in Behavioral Variant Frontotemporal Dementia: A Clinical And FDG-PET Study

2017 ◽  
Vol 57 (4) ◽  
pp. 1251-1264 ◽  
Author(s):  
Marta Fernández-Matarrubia ◽  
Jordi A. Matías-Guiu ◽  
María Nieves Cabrera-Martín ◽  
Teresa Moreno-Ramos ◽  
María Valles-Salgado ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Frontotemporal Dementia ◽  
Fdg Pet ◽  
Memory Dysfunction ◽  
Behavioral Variant Frontotemporal Dementia

Impact of Imaging and Cerebrospinal Fluid Biomarkers on Behavioral Variant Frontotemporal Dementia Diagnosis within a Late-Onset Frontal Lobe Syndrome Cohort

2015 ◽  
Vol 41 (1-2) ◽  
pp. 16-26 ◽  
Author(s):  
Welmoed A. Krudop ◽  
Annemiek Dols ◽  
Cora J. Kerssens ◽  
Niels D. Prins ◽  
Christiane Möller ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Frontotemporal Dementia ◽  
Frontal Lobe ◽  
Fdg Pet ◽  
Late Onset ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Diagnostic Certainty ◽  
18F Fdg ◽  
Frontal Lobe Syndrome ◽  
The Impact

Background: The criteria for behavioral variant frontotemporal dementia (bvFTD) incorporate MRI and [18F]-FDG-PET. Cerebrospinal fluid (CSF) analysis is merely advised for excluding Alzheimer's disease. Aims: We aimed to assess the impact of biomarkers on diagnostic certainty and contingent changes of bvFTD diagnosis within the clinically relevant neuropsychiatric differential diagnosis of subjects with a late-onset frontal lobe syndrome (LOF). Methods: We included 137 patients with LOF, aged 45-75 years, 72% males. Biomarker disclosure was considered contributing after any substantial difference in diagnostic certainty or a diagnostic change. Percentages of contributing biomarkers were compared between three major diagnostic groups (bvFTD, psychiatry, other neurological disorders). Certainty levels in stable diagnostic groups were compared to those with a diagnostic change. Results: Biomarkers contributed in 53, 60 and 41% of the LOF patients for MRI, [18F]-FDG-PET and CSF, respectively. Biomarkers changed the diagnosis in 14% of cases towards bvFTD and in 13% from bvFTD into an alternative. Those that changed had a lower level of a priori diagnostic certainty compared to stable diagnoses. Conclusion: Our study not only supports the widely accepted use of MRI and [18F]-FDG-PET in diagnosing or excluding bvFTD, but also shows that CSF biomarkers aid clinicians in the diagnostic process.

scholarly journals Meta-analytic Review of Memory Impairment in Behavioral Variant Frontotemporal Dementia

2018 ◽  
Vol 24 (6) ◽  
pp. 593-605 ◽  
Author(s):  
Jackie M. Poos ◽  
Lize C. Jiskoot ◽  
Janne M. Papma ◽  
John C. van Swieten ◽  
Esther van den Berg
Keyword(s):  
Episodic Memory ◽  
Frontotemporal Dementia ◽  
Memory Performance ◽  
Meta Analysis ◽  
Verbal Working Memory ◽  
Exclusion Criterion ◽  
Case Control Studies ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Analytic Review ◽  
Better Than

AbstractObjectives: A meta-analysis of the extent, nature and pattern of memory performance in behavioral variant frontotemporal dementia (bvFTD). Multiple observational studies have challenged the relative sparing of memory in bvFTD as stated in the current diagnostic criteria. Methods: We performed a meta-analytic review covering the period 1967 to February 2017 of case-control studies on episodic memory in bvFTD versus control participants (16 studies, 383 patients, 603 control participants), and patients with bvFTD versus those with Alzheimer’s disease (AD) (20 studies, 452 bvFTD, 874 AD). Differences between both verbal and non-verbal working memory, episodic memory learning and recall, and recognition memory were examined. Data were extracted from the papers and combined into a common metric measure of effect, Hedges’ d. Results: Patients with bvFTD show large deficits in memory performance compared to controls (Hedges’ d –1.10; 95% confidence interval [CI] [–1.23, –0.95]), but perform significantly better than patients with AD (Hedges’ d 0.85; 95% CI [0.69, 1.03]). Learning and recall tests differentiate best between patients with bvFTD and AD (p<.01). There is 37–62% overlap in test scores between the two groups. Conclusions: This study points to memory disorders in patients with bvFTD, with performance at an intermediate level between controls and patients with AD. This indicates that, instead of being an exclusion criterion for bvFTD diagnosis, memory deficits should be regarded as a potential integral part of the clinical spectrum. (JINS, 2018, 24, 593–605)

scholarly journals Diagnostic Accuracy of MRI and Additional [18F]FDG-PET for Behavioral Variant Frontotemporal Dementia in Patients with Late Onset Behavioral Changes

2016 ◽  
Vol 53 (4) ◽  
pp. 1287-1297 ◽  
Author(s):  
Everard G.B. Vijverberg ◽  
Mike P. Wattjes ◽  
Annemiek Dols ◽  
Welmoed A. Krudop ◽  
Christiane Möller ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Frontotemporal Dementia ◽  
Fdg Pet ◽  
Late Onset ◽  
Behavioral Changes ◽  
Behavioral Variant Frontotemporal Dementia ◽  
18F Fdg

scholarly journals Different patterns of gray matter atrophy in behavioral variant frontotemporal dementia with and without episodic memory impairment

2021 ◽  
Author(s):  
Elisa de Paula França Resende ◽  
Michael Hornberger ◽  
Henrique Cerqueira Guimarães ◽  
Leandro Boson Gambogi ◽  
Luciano Inácio Mariano ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Frontotemporal Dementia ◽  
Gray Matter ◽  
Memory Impairment ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Gray Matter Atrophy

P3-199: Episodic memory impairment in behavioral-variant frontotemporal dementia: A neuropsychological and a neuroimaging study

2015 ◽  
Vol 11 (7S_Part_15) ◽  
pp. P709-P709
Author(s):  
Leonardo Cruz de Souza ◽  
Henrique Cerqueira Guimarães ◽  
Maxime Bertoux ◽  
Michael Hornberger ◽  
Leandro Boson Gambogi ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Frontotemporal Dementia ◽  
Memory Impairment ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Neuroimaging Study

scholarly journals How preserved is episodic memory in behavioral variant frontotemporal dementia?

Neurology ◽  
2010 ◽  
Vol 74 (6) ◽  
pp. 472-479 ◽  
Author(s):  
M. Hornberger ◽  
O. Piguet ◽  
A. J. Graham ◽  
P. J. Nestor ◽  
J. R. Hodges
Keyword(s):  
Episodic Memory ◽  
Frontotemporal Dementia ◽  
Behavioral Variant Frontotemporal Dementia
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