Differential Hemispheric Predilection of Microstructural White Matter and Functional Connectivity Abnormalities between Respectively Semantic and Behavioral Variant Frontotemporal Dementia

2017 ◽  
Vol 56 (2) ◽  
pp. 789-804 ◽  
Author(s):  
Rozanna Meijboom ◽  
Rebecca M.E. Steketee ◽  
Leontine S. Ham ◽  
Aad van der Lugt ◽  
John C. van Swieten ◽  
...  
Keyword(s):  
White Matter ◽  
Functional Connectivity ◽  
Frontotemporal Dementia ◽  
Behavioral Variant Frontotemporal Dementia

scholarly journals Functional connectivity and microstructural white matter changes in phenocopy frontotemporal dementia

2016 ◽  
Vol 27 (4) ◽  
pp. 1352-1360 ◽  
Author(s):  
R. Meijboom ◽  
R. M. E. Steketee ◽  
I. de Koning ◽  
R. J. Osse ◽  
L. C. Jiskoot ◽  
...  
Keyword(s):  
White Matter ◽  
Functional Connectivity ◽  
Frontotemporal Dementia ◽  
White Matter Changes

scholarly journals White Matter Disease Contributes to Apathy and Disinhibition in Behavioral Variant Frontotemporal Dementia

2014 ◽  
Vol 27 (4) ◽  
pp. 206-214 ◽  
Author(s):  
John P. Powers ◽  
Lauren Massimo ◽  
Corey T. McMillan ◽  
Paul A. Yushkevich ◽  
Hui Zhang ◽  
...  
Keyword(s):  
White Matter ◽  
Frontotemporal Dementia ◽  
White Matter Disease ◽  
Behavioral Variant Frontotemporal Dementia

scholarly journals Multimodal MRI of grey matter, white matter, and functional connectivity in cognitively healthy mutation carriers at risk for frontotemporal dementia and Alzheimer's disease

BMC Neurology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Rogier A. Feis ◽  
Mark J. R. J. Bouts ◽  
Elise G. P. Dopper ◽  
Nicola Filippini ◽  
Verena Heise ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
White Matter ◽  
Functional Connectivity ◽  
Frontotemporal Dementia ◽  
Grey Matter ◽  
Region Of Interest ◽  
Grey Matter Volume ◽  
Matter Volume ◽  
Mutation Carriers ◽  
Healthy Carriers

Abstract Background Frontotemporal dementia (FTD) and Alzheimer’s disease (AD) are associated with divergent differences in grey matter volume, white matter diffusion, and functional connectivity. However, it is unknown at what disease stage these differences emerge. Here, we investigate whether divergent differences in grey matter volume, white matter diffusion, and functional connectivity are already apparent between cognitively healthy carriers of pathogenic FTD mutations, and cognitively healthy carriers at increased AD risk. Methods We acquired multimodal magnetic resonance imaging (MRI) brain scans in cognitively healthy subjects with (n=39) and without (n=36) microtubule-associated protein Tau (MAPT) or progranulin (GRN) mutations, and with (n=37) and without (n=38) apolipoprotein E ε4 (APOE4) allele. We evaluated grey matter volume using voxel-based morphometry, white matter diffusion using tract-based spatial statistics (TBSS), and region-to-network functional connectivity using dual regression in the default mode network and salience network. We tested for differences between the respective carriers and controls, as well as for divergence of those differences. For the divergence contrast, we additionally performed region-of-interest TBSS analyses in known areas of white matter diffusion differences between FTD and AD (i.e., uncinate fasciculus, forceps minor, and anterior thalamic radiation). Results MAPT/GRN carriers did not differ from controls in any modality. APOE4 carriers had lower fractional anisotropy than controls in the callosal splenium and right inferior fronto-occipital fasciculus, but did not show grey matter volume or functional connectivity differences. We found no divergent differences between both carrier-control contrasts in any modality, even in region-of-interest analyses. Conclusions Concluding, we could not find differences suggestive of divergent pathways of underlying FTD and AD pathology in asymptomatic risk mutation carriers. Future studies should focus on asymptomatic mutation carriers that are closer to symptom onset to capture the first specific signs that may differentiate between FTD and AD.

Clinical and Biological Correlates of White Matter Hyperintensities in Patients With Behavioral-Variant Frontotemporal Dementia and Alzheimer Disease

Neurology ◽  
2021 ◽  
Vol 96 (13) ◽  
pp. e1743-e1754
Author(s):  
Katharine Huynh ◽  
Olivier Piguet ◽  
John Kwok ◽  
Carol Dobson-Stone ◽  
Glenda M. Halliday ◽  
...  
Keyword(s):  
White Matter ◽  
Alzheimer Disease ◽  
Frontotemporal Dementia ◽  
Disease Severity ◽  
White Matter Hyperintensities ◽  
Brain Mri ◽  
Cortical Atrophy ◽  
Vascular Risk ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Cognitive Domains

ObjectiveTo test the hypothesis that white matter hyperintensities (WMH) in behavioral-variant frontotemporal dementia (bvFTD) and Alzheimer disease (AD) are associated with disease variables such as disease severity, cortical atrophy, and cognition, we conducted a cross-sectional brain MRI study with volumetric and voxel-wise analyses.MethodsA total of 129 patients (64 bvFTD, 65 AD) and 66 controls underwent high-resolution brain MRI and clinical and neuropsychological examination. Genetic screening was conducted in 124 cases (54 bvFTD, 44 AD, 26 controls) and postmortem pathology was available in 18 cases (13 bvFTD, 5 AD). WMH were extracted using an automated segmentation algorithm and analyses of total volumes and spatial distribution were conducted. Group differences in total WMH volume and associations with vascular risk and disease severity were examined. Syndrome-specific voxel-wise associations between WMH, cortical atrophy, and performance across different cognitive domains were assessed.ResultsTotal WMH volumes were larger in patients with bvFTD than patients with AD and controls. In bvFTD, WMH volumes were associated with disease severity but not vascular risk. Patients with bvFTD and patients with AD showed distinct spatial patterns of WMH that mirrored characteristic patterns of cortical atrophy. Regional WMH load correlated with worse cognitive performance in discrete cognitive domains. WMH-related cognitive impairments were shared between syndromes, with additional associations found in bvFTD.ConclusionIncreased WMH are common in patients with bvFTD and patients with AD. Our findings suggest that WMH are partly independent of vascular pathology and associated with the neurodegenerative process. WMH occur in processes independent of and related to cortical atrophy. Furthermore, increased WMH in different regions contributes to cognitive deficits.

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