The Longitudinal Decline of White Matter Microstructural Integrity in Behavioral Variant Frontotemporal Dementia and Its Association with Executive Function

2018 ◽  
Author(s):  
Junhong Yu ◽  
Tatia M.C. Lee
Keyword(s):  
Executive Function ◽  
White Matter ◽  
Frontotemporal Dementia ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Microstructural Integrity

scholarly journals Microstructural degeneration underlies executive dysfunction after stroke

2020 ◽  
Author(s):  
Michele Veldsman ◽  
Emilio Werden ◽  
Natalia Egorova ◽  
Mohamed Salah Khlif ◽  
Amy Brodtmann
Keyword(s):  
Executive Function ◽  
White Matter ◽  
Structural Equation ◽  
Executive Dysfunction ◽  
White Matter Integrity ◽  
Stroke Severity ◽  
Lesion Volume ◽  
Stroke Patients ◽  
Cerebrovascular Risk ◽  
Microstructural Integrity

ABSTRACTObjectiveExecutive dysfunction affects 40% of stroke patients and is associated with poor quality of life. Stroke severity and lesion volume rarely predict whether a patient will have executive dysfunction. Stroke typically occurs on a background of cerebrovascular burden, which impacts cognition and brain network structural integrity. We investigated whether measures of white matter microstructural integrity and cerebrovascular risk factors better explain executive dysfunction than markers of stroke severity.MethodsWe used structural equation modelling to examine multivariate relationships between cerebrovascular risk, white matter microstructural integrity (fractional anisotropy and mean diffusivity), stroke characteristics and executive dysfunction in 126 stroke patients (mean age 68.4 years), three months post-stroke, and compared to 40 age- and sex-matched control participants. Executive function was measured using the Trail Making Tests, Clock Drawing task and Rey Complex Figure copy task. Microstructural integrity was estimated using a standard pipeline to process diffusion weighted images.ResultsExecutive function was below what would be expected for age and education level in stroke patients (t-test compared to controls t(79)=5.75, p<0.001). A multivariate structural equation model illustrated the complex relationship between executive function, white matter integrity, stroke characteristics and cerebrovascular risk. Pearson’s correlations confirmed a stronger relationship between executive dysfunction and white matter integrity, than executive dysfunction and stroke severity. Mediation analysis showed the relationship between executive function and white matter integrity is mediated by cerebrovascular burden.InterpretationWhite matter microstructural degeneration of the superior longitudinal fasciculus in the executive control network better explains executive dysfunction than markers of stroke severity.

Abstract P366: High Burden of Tract-Specific White Matter Hyperintensities Relates to Impaired Microstructural Integrity of Distal White Matter Tracts in Community-Dwelling Elders

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
YANPENG LIU ◽  
YIWEI XIA ◽  
XIAOXIAO WANG ◽  
YI WANG ◽  
LUMENG YANG ◽  
...  
Keyword(s):  
Executive Function ◽  
White Matter ◽  
Cognitive Dysfunction ◽  
White Matter Hyperintensities ◽  
Brain Mri ◽  
Mean Diffusivity ◽  
Community Dwelling ◽  
Superior Longitudinal Fasciculus ◽  
High Burden ◽  
Microstructural Integrity

Background and purpose: White matter hyperintensities (WMH) are common in elderly individuals and contribute to age-related cognitive dysfunction. Converging evidence indicates that WMH affect white matter (WM) microstructural integrity in WMH and their penumbra. We aimed to investigate whether this effect extends to the distal WM tracts, and to examine the association between distal WM microstructural integrity and cognitive dysfunction in community-dwelling elderly people. Methods: Brain MRI data including FLAIR and DTI sequences of 174 participants (74 ± 5 years) of the Shanghai Aging Study (SAS) were collected and analyzed. For each participant, WMH lesions were segmented automatically. Eighteen major WM tracts were reconstructed using automated quantitative tractography, and the mean diffusivity (MD) of distal WM tracts (excluding an area of 12 mm around the WMH) was calculated. Multivariable linear regression was performed. Results: A high burden of tract-specific WMH was related to a high MD of distal WM tracts in the forceps major (FMA), anterior thalamic radiations (ATR), cingulum cingulate gyrus (CCG), corticospinal tract (CST), superior longitudinal fasciculus-parietal (SLFP), superior longitudinal fasciculus-temporal (SLFT), and uncinate fasciculus (UNC). Furthermore, a high MD of distal tracts was linked to worse attention and executive function in the forceps minor (FMI), right CCG, left inferior longitudinal fasciculus (ILF), SLFP, SLFT and UNC. Conclusions: The effect of WMH on the microstructural integrity of WM tracts may propagate along tracts to distal regions farther than the penumbra and eventually might affect attention and executive function.

Association between microstructural integrity of frontostriatal tracts and school functioning: ADHD symptoms and executive function as mediators

2014 ◽  
Vol 45 (3) ◽  
pp. 529-543 ◽  
Author(s):  
S. S. Gau ◽  
W.-L. Tseng ◽  
W.-Y. I. Tseng ◽  
Y.-H. Wu ◽  
Y.-C. Lo
Keyword(s):  
Executive Function ◽  
White Matter ◽  
Response Inhibition ◽  
Neuropsychological Test ◽  
School Functioning ◽  
White Matter Integrity ◽  
Future Research ◽  
Adhd Symptoms ◽  
Diffusion Spectrum Imaging ◽  
Microstructural Integrity

BackgroundDeficits in executive function (EF), impaired school functioning and altered white matter integrity in frontostriatal networks have been associated with attention-deficit/hyperactivity disorder (ADHD). However, relationships between impairments in these areas are unclear. Using a sample of youths with and without ADHD, this study examined the association between microstructural integrity of frontostriatal tracts and school dysfunction and the mediating roles of EF and ADHD symptoms in this association.MethodThe sample included 32 Taiwanese youths with ADHD and 32 age-, sex-, handedness- and IQ-matched typically-developing (TD) youths. Participants were assessed using psychiatric interviews, parent reports on ADHD symptoms and school functioning, and EF measures from the Cambridge Neuropsychological Test Automated Battery (CANTAB). The frontostriatal tracts were reconstructed by diffusion spectrum imaging (DSI) tractography and were subdivided into four functionally distinct segments: caudate–dorsolateral, caudate–medial prefrontal, caudate–orbitofrontal and caudate–ventrolateral tracts.ResultsYouths with ADHD, relative to TD youths, showed altered white matter integrity in all four bilateral pairs of frontostriatal tracts (decreased general fractional anisotropy, GFA), had poor attention, vigilance and response inhibition, and showed impaired school functioning. Altered microstructural integrity in frontostriatal tracts was significantly associated with school dysfunction, which was mediated by EF measures of attention/vigilance and response inhibition in addition to inattention and hyperactivity symptoms.ConclusionsOur findings demonstrate an association between white matter integrity in the frontostriatal networks and school functioning and suggest that EF deficits and ADHD symptoms may be the mediating mechanisms for this association. Future research is needed to test the directionality and specificity of this finding.

scholarly journals White Matter Disease Contributes to Apathy and Disinhibition in Behavioral Variant Frontotemporal Dementia

2014 ◽  
Vol 27 (4) ◽  
pp. 206-214 ◽  
Author(s):  
John P. Powers ◽  
Lauren Massimo ◽  
Corey T. McMillan ◽  
Paul A. Yushkevich ◽  
Hui Zhang ◽  
...  
Keyword(s):  
White Matter ◽  
Frontotemporal Dementia ◽  
White Matter Disease ◽  
Behavioral Variant Frontotemporal Dementia

[P2-467]: TESTS OF EXECUTIVE FUNCTION MAY NOT DIFFERENTIATE ALZHEIMER's DISEASE FROM BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA

2017 ◽  
Vol 13 (7S_Part_16) ◽  
pp. P819-P819
Author(s):  
Monica Sanches Yassuda ◽  
Valeria S. Bahia ◽  
Mario Amore Cecchini ◽  
Luciana Cassimiro ◽  
Thais Bento Lima-Silva ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Executive Function ◽  
Frontotemporal Dementia ◽  
Behavioral Variant Frontotemporal Dementia
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