Why Should I Care? Dimensions of Socio-Emotional Cognition in Younger-Onset Dementia

2015 ◽  
Vol 48 (1) ◽  
pp. 135-147 ◽  
Author(s):  
Rosalind Hutchings ◽  
John R. Hodges ◽  
Olivier Piguet ◽  
Fiona Kumfor
Keyword(s):  
Emotional Cognition

Emotional cognition subgroups in unaffected first-degree relatives of patients with mood disorders

2021 ◽  
pp. 1-11
Author(s):  
Hanne Lie Kjærstad ◽  
Cristina Varo ◽  
Iselin Meluken ◽  
Eduard Vieta ◽  
Maj Vinberg ◽  
...  
Keyword(s):  
Mood Disorders ◽  
Familial Risk ◽  
Hierarchical Cluster ◽  
Expression Recognition ◽  
Neurocognitive Performance ◽  
Cognitive Markers ◽  
First Degree Relatives ◽  
Probe Test ◽  
Data Driven Approach ◽  
Emotional Cognition

Abstract Background Patients with major depressive disorder (MDD) or bipolar disorder (BD) exhibit difficulties with emotional cognition even during remission. There is evidence for aberrant emotional cognition in unaffected relatives of patients with these mood disorders, but studies are conflicting. We aimed to investigate whether emotional cognition in unaffected first-degree relatives of patients with mood disorders is characterised by heterogeneity using a data-driven approach. Methods Data from 94 unaffected relatives (33 of MDD patients; 61 of BD patients) and 203 healthy controls were pooled from two cohort studies. Emotional cognition was assessed with the Social Scenarios Test, Facial Expression Recognition Test and Faces Dot-Probe Test. Hierarchical cluster analysis was conducted using emotional cognition data from the 94 unaffected relatives. The resulting emotional cognition clusters and controls were compared for emotional and non-emotional cognition, demographic characteristics and functioning. Results Two distinct clusters of unaffected relatives were identified: a relatively ‘emotionally preserved’ cluster (55%; 40% relatives of MDD probands) and an ‘emotionally blunted’ cluster (45%; 29% relatives of MDD probands). ‘Emotionally blunted’ relatives presented with poorer neurocognitive performance (global cognition p = 0.010), heightened subsyndromal mania symptoms (p = 0.004), lower years of education (p = 0.004) and difficulties with interpersonal functioning (p = 0.005) than controls, whereas ‘emotionally preserved’ relatives were comparable to controls on these measures. Conclusions Our findings show discrete emotional cognition profiles that occur across healthy first-degree relatives of patients with MDD and BD. These emotional cognition clusters may provide insight into emotional cognitive markers of genetically distinct subgroups of individuals at familial risk of mood disorders.

scholarly journals Auditory Emotional Cognition Development with Cochlear Implant.

2003 ◽  
Vol 44 (1) ◽  
pp. 15-22
Author(s):  
Nobuyuki Nonaka ◽  
Takuya Murao ◽  
Shun-ichi Sakai ◽  
Sei Nakazima ◽  
Akemi Baba ◽  
...  
Keyword(s):  
Cochlear Implant ◽  
Emotional Cognition

scholarly journals Emotional Cognition without Awareness after Unilateral Temporal Lobectomy in Humans

2000 ◽  
Vol 20 (19) ◽  
pp. RC97-RC97 ◽  
Author(s):  
Yasutaka Kubota ◽  
Wataru Sato ◽  
Toshiya Murai ◽  
Motomi Toichi ◽  
Akio Ikeda ◽  
...  
Keyword(s):  
Temporal Lobectomy ◽  
Emotional Cognition

scholarly journals The posterior crus II cerebellum is specialized for social mentalizing and emotional self-experiences: a meta-analysis

2020 ◽  
Vol 15 (9) ◽  
pp. 905-928 ◽  
Author(s):  
Frank Van Overwalle ◽  
Qianying Ma ◽  
Elien Heleven
Keyword(s):  
Meta Analysis ◽  
Domain Specific ◽  
Social Actions ◽  
The Social ◽  
High Incidence ◽  
Sequencing Studies ◽  
Crus I ◽  
Social Mentalizing ◽  
Emotional Cognition

Abstract This meta-analysis explores the role of the posterior cerebellum Crus I/II in social mentalizing. We identified over 200 functional magnetic resonance imaging (fMRI) studies via NeuroSynth that met our inclusion criteria and fell within bilateral Crus II areas related to ‘sequencing’ during mentalizing (coordinates ±24 −76 −40; from earlier studies) and mere social ‘mentalizing’ or self-related emotional cognition (coordinates ±26 −84 −34; from NeuroSynth), located in the cerebellar mentalizing network. A large majority of these studies (74%) involved mentalizing or self-related emotional cognition. Other functions formed small minorities. This high incidence in Crus II compares very favorably against the lower base rate for mentalizing and self-related emotions (around 35%) across the whole brain as revealed in NeuroSynth. In contrast, there was much less support for a similar role of Crus I (coordinates −40 −70 −40 from earlier ‘sequencing’ studies) as only 35% of the studies were related to mentalizing or self-related emotions. The present findings show that a domain-specific social mentalizing functionality is supported in the cerebellar Crus II. This has important implications for theories of the social cerebellum focusing on sequencing of social actions, and for cerebellar neurostimulation treatments.

Neurocognitive heterogeneity in patients with bipolar disorder and their unaffected relatives: associations with emotional cognition

2019 ◽  
pp. 1-12 ◽  
Author(s):  
Hanne Lie Kjærstad ◽  
Fillip Ferreira Eikeseth ◽  
Maj Vinberg ◽  
Lars Vedel Kessing ◽  
Kamilla Miskowiak
Keyword(s):  
Bipolar Disorder ◽  
Facial Expression ◽  
Facial Expression Recognition ◽  
Clinical Sample ◽  
Cognitively Impaired ◽  
Expression Recognition ◽  
Cluster Assignment ◽  
Neurocognitive Impairments ◽  
Cognitively Intact ◽  
Emotional Cognition

Abstract Background Recent evidence suggests that neurocognitive impairments in remitted patients with bipolar disorder (BD) are heterogeneous. Our study aims to replicate recent findings of neurocognitive subgroups, and further explore whether these are related to impairments in affective cognition, in a large sample of remitted patients recently diagnosed with BD and their unaffected relatives compared to healthy controls (HCs). Methods Hierarchal cluster analysis was conducted using neurocognitive data from remitted patients with BD (n = 158). Relatives of patients with BD (n = 52) were categorised into groups consistent with their affected relative's cluster assignment. The neurocognitive clusters of patients with BD and relatives, respectively, were compared with HCs (n = 110) in neurocognition and affective cognition (i.e. emotion processing and regulation). Results Three discrete neurocognitive clusters were identified in patients with BD: a globally impaired (23.4%), a selectively impaired (31.0%) and a cognitively intact cluster (45.6%). The neurocognitive subgroups differed in affective cognition, with patients categorised as globally impaired exhibited most impairments in facial expression recognition and emotion regulation in social scenarios. First-degree relatives of cognitively impaired patients displayed impaired facial expression recognition but no impairments in non-emotional cognition. Conclusions In a clinical sample of remitted patients recently diagnosed with BD 54.4% had either global or selective cognitive impairment, replicating results of previous studies in patients with longer illness duration. The results suggest that patterns of neurocognition are associated with differential impairments in affective cognition. Aberrant affective cognition in relatives of patients categorised as neurocognitively impaired indicates an inherited risk for BD.

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