Hippocampal Disconnection in Early Alzheimer's Disease: A 7 Tesla MRI Study

2015 ◽  
Vol 45 (4) ◽  
pp. 1247-1256 ◽  
Author(s):  
Laura E.M. Wisse ◽  
Yael D. Reijmer ◽  
Annemieke ter Telgte ◽  
Hugo J. Kuijf ◽  
Alexander Leemans ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
7 Tesla ◽  
7 Tesla Mri ◽  
Early Alzheimer’S Disease ◽  
Mri Study

P4-059: Hippocampal microstructure and memory performance in Alzheimer's disease: A 7-Tesla MRI study

2011 ◽  
Vol 7 ◽  
pp. S719-S719
Author(s):  
Geoffrey Kerchner ◽  
Gayle Deutsch ◽  
Michael Zeineh ◽  
Brian Rutt
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Memory Performance ◽  
7 Tesla ◽  
7 Tesla Mri ◽  
Mri Study

IC-P-127: Hippocampal microstructure and memory performance in Alzheimer's disease: A 7-Tesla MRI study

2011 ◽  
Vol 7 ◽  
pp. S60-S61
Author(s):  
Geoffrey Kerchner ◽  
Gayle Deutsch ◽  
Michael Zeineh ◽  
Brian Rutt
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Memory Performance ◽  
7 Tesla ◽  
7 Tesla Mri ◽  
Mri Study

IC-03-04: Hippocampal neuropil atrophy in early Alzheimer's disease: A 7T MRI study

2010 ◽  
Vol 6 ◽  
pp. S59-S60
Author(s):  
Geoffrey A. Kerchner ◽  
Christopher P. Hess ◽  
Kathryn Hammond-Rosenbluth ◽  
Duan Xu ◽  
Douglas A.C. Kelley ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Alzheimer’S Disease ◽  
Mri Study

scholarly journals Corpus Callosum Atrophy and Cognitive Decline in Early Alzheimer's Disease: Longitudinal MRI Study

2014 ◽  
Vol 37 (3-4) ◽  
pp. 214-222 ◽  
Author(s):  
Minwei Zhu ◽  
Xudong Wang ◽  
Wenpeng Gao ◽  
Chen Shi ◽  
Haitao Ge ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Corpus Callosum ◽  
Cognitive Decline ◽  
Longitudinal Mri ◽  
Early Alzheimer’S Disease ◽  
Mri Study

scholarly journals Corpus callosum shape changes in early Alzheimer’s disease: an MRI study using the OASIS brain database

2013 ◽  
Vol 219 (1) ◽  
pp. 343-352 ◽  
Author(s):  
Babak A. Ardekani ◽  
Alvin H. Bachman ◽  
Khadija Figarsky ◽  
John J. Sidtis
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Corpus Callosum ◽  
Early Alzheimer’S Disease ◽  
Mri Study ◽  
Shape Changes

scholarly journals Cerebral microbleeds on 7 Tesla MRI in preclinical Alzheimer’s disease: The Medea‐7T study

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Maarten H.T. Zwartbol ◽  
Rashid Ghaznawi ◽  
Kim Blom ◽  
Hugo J. Kuijf ◽  
Theo Witkamp ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebral Microbleeds ◽  
7 Tesla ◽  
Preclinical Alzheimer’S Disease ◽  
7 Tesla Mri

scholarly journals Microbleeds colocalize with enlarged juxtacortical perivascular spaces in amnestic mild cognitive impairment and early Alzheimer’s disease: A 7 Tesla MRI study

2019 ◽  
Vol 40 (4) ◽  
pp. 739-746 ◽  
Author(s):  
Willem H Bouvy ◽  
Susanne J van Veluw ◽  
Hugo J Kuijf ◽  
Jaco JM Zwanenburg ◽  
Jaap L Kappelle ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amnestic Mild Cognitive Impairment ◽  
7 Tesla ◽  
Rank Test ◽  
Amyloid Angiopathy ◽  
Perivascular Spaces ◽  
Early Alzheimer’S Disease

MRI-visible perivascular spaces (PVS) in the semioval centre are associated with cerebral amyloid angiopathy (CAA), but it is unknown if PVS co-localize with MRI markers of CAA. To examine this, we assessed the topographical association between cortical cerebral microbleeds (CMBs) – as an indirect marker of CAA – and dilatation of juxtacortical perivascular spaces (jPVS) in 46 patients with amnestic mild cognitive impairment (aMCI) or early Alzheimer’s disease (eAD). The degree of dilatation of jPVS <1 cm around each cortical CMBs was compared with a similar reference site (no CMB) in the contralateral hemisphere, using a 4-point scale. Also, jPVS dilatation was compared between patients with and without cortical CMBs. Eleven patients (24%) had cortical CMBs [total=35, median=1, range=1–14] of whom five had >1 cortical CMBs. The degree of jPVS dilatation was higher around CMBs than at the reference sites [Wilcoxon signed rank test, Z = 2.2, p = 0.03]. Patients with >1 cortical CMBs had a higher degree of jPVS dilation [median=2.2, IQR = 1.8–2.3] than patients without cortical CMBs [median=1.4, IQR = 1.0–1.8], p = 0.02. We found a topographical association between a high degree of jPVS dilatation and cortical CMBs, supporting a common underlying pathophysiology – most likely CAA.

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