scholarly journals Cerebral Blood Flow Measured by Arterial Spin Labeling MRI as a Preclinical Marker of Alzheimer's Disease

2014 ◽  
Vol 42 (s4) ◽  
pp. S411-S419 ◽  
Author(s):  
Christina E. Wierenga ◽  
Chelsea C. Hays ◽  
Zvinka Z. Zlatar
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling

Simultaneous Arterial Spin Labeling Cerebral Blood Flow and Morphological Assessments for Detection of Alzheimer’s Disease

2011 ◽  
Vol 18 (12) ◽  
pp. 1492-1499 ◽  
Author(s):  
Tuvshinjargal Dashjamts ◽  
Takashi Yoshiura ◽  
Akio Hiwatashi ◽  
Koji Yamashita ◽  
Akira Monji ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling

scholarly journals Longitudinal Cerebral Blood Flow Changes in Normal Aging and the Alzheimer’s Disease Continuum Identified by Arterial Spin Labeling MRI

2021 ◽  
pp. 1-9
Author(s):  
Aldo Camargo ◽  
Ze Wang ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Prefrontal Cortex ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Normal Aging ◽  
Perfusion Magnetic Resonance Imaging ◽  
Cross Sectional

Background: Cross-sectional studies have shown lower cerebral blood flow (CBF) in Alzheimer’s disease (AD), but longitudinal CBF changes in AD are still unknown. Objective: To reveal the longitudinal CBF changes in normal control (NC) and the AD continuum using arterial spin labeling perfusion magnetic resonance imaging (ASL MRI). Methods: CBF was calculated from two longitudinal ASL scans acquired 2.22±1.43 years apart from 140 subjects from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). At the baseline scan, the cohort contained 41 NC, 74 mild cognitive impairment patients (MCI), and 25 AD patients. 21 NC converted into MCI and 17 MCI converted into AD at the follow-up. Longitudinal CBF changes were assessed using paired-t test for non-converters and converters separately at each voxel and in the meta-ROI. Age and sex were used as covariates. Results: CBF reductions were observed in all subjects. Stable NC (n = 20) showed CBF reduction in the hippocampus and precuneus. Stable MCI patients (n = 57) showed spatially more extended CBF reduction patterns in hippocampus, middle temporal lobe, ventral striatum, prefrontal cortex, and cerebellum. NC-MCI converters showed CBF reduction in hippocampus and cerebellum and CBF increase in caudate. MCI-AD converters showed CBF reduction in hippocampus and prefrontal cortex. CBF changes were not related with longitudinal neurocognitive changes. Conclusion: Normal aging and AD continuum showed common longitudinal CBF reductions in hippocampus independent of disease and its conversion. Disease conversion independent longitudinal CBF reductions escalated in MCI subjects.

scholarly journals Regional Cerebral Blood Flow in Mild Cognitive Impairment and Alzheimer’s Disease Measured with Arterial Spin Labeling Magnetic Resonance Imaging

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Alba Sierra-Marcos
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Arterial Spin Labeling ◽  
Regional Cerebral Blood Flow ◽  
Spin Labeling ◽  
Regional Cerebral Blood

Alzheimer’s disease (AD) depicts dynamic changes in regional brain function from early stages of the disease. Arterial spin labeling- (ASL-) based MRI methods have been applied for detecting regional cerebral blood flow (rCBF) perfusion changes in patients with AD and mild cognitive impairment (MCI). Nevertheless, the results obtained from ASL studies in AD and MCI are still controversial, since rCBF maps may show both hypoperfusion or hyperperfusion areas in brain structures involved in different cognitive functions. The goal of this review is to provide the current state of the art regarding the role of ASL for detecting distinctive perfusion patterns in subjects with MCI and/or AD. The ability to obtain this information using a noninvasive and widely available modality such as ASL should greatly enhance the knowledge into the broad range of hemodynamically related changes taking place during the cognitive decline process in AD.

P2-252: Cerebral blood flow changes in early Alzheimer's disease: A high-field arterial spin labeling perfusion MRI study

2012 ◽  
Vol 8 (4S_Part_9) ◽  
pp. P350-P350
Author(s):  
Xiaowei Song ◽  
Chen Wei ◽  
Ryan D'Arcy ◽  
Steven Beyea ◽  
Careesa Liu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
High Field ◽  
Spin Labeling ◽  
Perfusion Mri ◽  
Flow Changes ◽  
Early Alzheimer’S Disease ◽  
Mri Study
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