Nutraceuticals: A Novel Concept in Prevention and Treatment of Alzheimer's Disease and Related Disorders

2014 ◽  
Vol 42 (2) ◽  
pp. 357-367 ◽  
Author(s):  
Gonzalo A. Farías ◽  
Leonardo Guzmán-Martínez ◽  
Carolina Delgado ◽  
Ricardo B. Maccioni
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prevention And Treatment ◽  
Novel Concept

Synthesis of New Peptide Derivatives of Galanthamine Designed for Prevention and Treatment of Alzheimer’s Disease

2015 ◽  
Vol 22 (10) ◽  
pp. 913-922 ◽  
Author(s):  
Lyubomir Vezenkov ◽  
Lilia Ilieva ◽  
Dancho Danalev ◽  
Anastasia Bakalova ◽  
D. Vassilev ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prevention And Treatment ◽  
Peptide Derivatives ◽  
Derivatives Of

scholarly journals Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease

2018 ◽  
Vol 13 (4) ◽  
pp. 742 ◽  
Author(s):  
Kun Zhang ◽  
Min Chen ◽  
Zhi-Yun Du ◽  
Xi Zheng ◽  
Dong-Li Li ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prevention And Treatment

Alzheimer’s Disease: From Amyloid to Autoimmune Hypothesis

2020 ◽  
Vol 26 (5-6) ◽  
pp. 455-470
Author(s):  
Yuri I. Arshavsky
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Immune System ◽  
Pyramidal Neurons ◽  
Adaptive Immune System ◽  
Memory Formation ◽  
Autoimmune Response ◽  
Prevention And Treatment ◽  
Ad Prevention ◽  
Clinical Verification

Although Alzheimer’s disease (AD) was described over a century ago, there are no effective approaches to its prevention and treatment. Such a slow progress is explained, at least in part, by our incomplete understanding of the mechanisms underlying the pathogenesis of AD. Here, I champion a hypothesis whereby AD is initiated on a disruption of the blood-brain barrier (BBB) caused by either genetic or non-genetic risk factors. The BBB disruption leads to an autoimmune response against pyramidal neurons located in the allo- and neocortical structures involved in memory formation and storage. The response caused by the adaptive immune system is not strong enough to directly kill neurons but may be sufficient to make them selectively vulnerable to neurofibrillary pathology. This hypothesis is based on the recent data showing that memory formation is associated with epigenetic chromatin modifications and, therefore, may be accompanied by expression of memory-specific proteins recognized by the immune system as “non-self” antigens. The autoimmune hypothesis is testable, and I discuss potential ways for its experimental and clinical verification. If confirmed, this hypothesis can radically change therapeutic approaches to AD prevention and treatment.

The Emerging Role of Nutraceuticals and Phytochemicals in the Prevention and Treatment of Alzheimer’s Disease

2020 ◽  
pp. 1-19 ◽  
Author(s):  
Camila Calfio ◽  
Andrea Gonzalez ◽  
Sandeep Kumar Singh ◽  
Leonel E. Rojo ◽  
Ricardo B. Maccioni
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prevention And Treatment
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