Evaluation of the Posterior Cingulate Region with FDG-PET and Advanced MR Techniques in Patients with Amnestic Mild Cognitive Impairment: Comparison of the Methods

2015 ◽  
Vol 44 (1) ◽  
pp. 329-338 ◽  
Author(s):  
Anna Zimny ◽  
Joanna Bladowska ◽  
Adam Macioszek ◽  
Paweł Szewczyk ◽  
Elzbieta Trypka ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Fdg Pet ◽  
Amnestic Mild Cognitive Impairment ◽  
Posterior Cingulate

P2-185 Glucose metabolic patterns in amnestic mild cognitive impairment and Alzheimer's disease; an FDG pet study

2004 ◽  
Vol 25 ◽  
pp. S280
Author(s):  
Kejal Kantarci ◽  
Bradley J. Kemp ◽  
Val J. Lowe ◽  
Ronald C. Petersen ◽  
Bradley F. Boeve ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Fdg Pet ◽  
Amnestic Mild Cognitive Impairment

P3-225: POSTERIOR CINGULATE GABA AND GLX ARE REDUCED IN AMNESTIC MILD COGNITIVE IMPAIRMENT

2014 ◽  
Vol 10 ◽  
pp. P713-P713
Author(s):  
Florian Riese ◽  
Anton Gietl ◽  
Nikolaus Zölch ◽  
Anke Henning ◽  
Ruth O'Gorman ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amnestic Mild Cognitive Impairment ◽  
Posterior Cingulate

scholarly journals Anosognosia predicts default mode network hypometabolism and clinical progression to dementia

Neurology ◽  
2018 ◽  
Vol 90 (11) ◽  
pp. e932-e939 ◽  
Author(s):  
Joseph Therriault ◽  
Kok Pin Ng ◽  
Tharick A. Pascoal ◽  
Sulantha Mathotaarachchi ◽  
Min Su Kang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Default Mode Network ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Amnestic Mild Cognitive Impairment ◽  
Default Mode ◽  
Posterior Cingulate ◽  
Impaired Awareness

ObjectiveTo identify the pathophysiologic mechanisms and clinical significance of anosognosia for cognitive decline in mild cognitive impairment.MethodsWe stratified 468 patients with amnestic mild cognitive impairment into intact and impaired awareness groups, determined by the discrepancy between the patient and the informant score on the Everyday Cognition questionnaire. Voxel-based linear regression models evaluated the associations between self-awareness status and baseline β-amyloid load, measured by [18F]florbetapir, and the relationships between awareness status and regional brain glucose metabolism measured by [18F]fluorodeoxyglucose at baseline and at 24-month follow-up. Multivariate logistic regression tested the association of awareness status with conversion from amnestic mild cognitive impairment to dementia.ResultsWe found that participants with impaired awareness had lower [18F]fluorodeoxyglucose uptake and increased [18F]florbetapir uptake in the posterior cingulate cortex at baseline. In addition, impaired awareness in mild cognitive impairment predicted [18F]fluorodeoxyglucose hypometabolism in the posterior cingulate cortex, left basal forebrain, bilateral medial temporal lobes, and right lateral temporal lobe over 24 months. Furthermore, participants with impaired awareness had a nearly 3-fold increase in likelihood of conversion to dementia within a 2-year time frame.ConclusionsOur results suggest that anosognosia is linked to Alzheimer disease pathophysiology in vulnerable structures, and predicts subsequent hypometabolism in the default mode network, accompanied by an increased risk of progression to dementia. This highlights the importance of assessing awareness of cognitive decline in the clinical evaluation and management of individuals with amnestic mild cognitive impairment.

scholarly journals Analysis of the posterior cingulate cortex with [ 18 F]FDG-PET and Naa/mI in mild cognitive impairment and Alzheimer's disease: Correlations and differences between the two methods

2015 ◽  
Vol 9 (4) ◽  
pp. 385-393 ◽  
Author(s):  
Artur M.N. Coutinho ◽  
Fábio H.G. Porto ◽  
Poliana F. Zampieri ◽  
Maria C. Otaduy ◽  
Tíbor R. Perroco ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Fdg Pet ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Cognitively Normal ◽  
Posterior Cingulate ◽  
18F Fdg

ABSTRACT Reduction of regional brain glucose metabolism (rBGM) measured by [18F]FDG-PET in the posterior cingulate cortex (PCC) has been associated with a higher conversion rate from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Magnetic Resonance Spectroscopy (MRS) is a potential biomarker that has disclosed Naa/mI reductions within the PCC in both MCI and AD. Studies investigating the relationships between the two modalities are scarce. OBJECTIVE To evaluate differences and possible correlations between the findings of rBGM and NAA/mI in the PCC of individuals with AD, MCI and of cognitively normal volunteers. METHODS Patients diagnosed with AD (N=32) or MCI (N=27) and cognitively normal older adults (CG, N=28), were submitted to [18F]FDG-PET and MRS to analyze the PCC. The two methods were compared and possible correlations between the modalities were investigated. RESULTS The AD group exhibited rBGM reduction in the PCC when compared to the CG but not in the MCI group. MRS revealed lower NAA/mI values in the AD group compared to the CG but not in the MCI group. A positive correlation between rBGM and NAA/mI in the PCC was found. NAA/mI reduction in the PCC differentiated AD patients from control subjects with an area under the ROC curve of 0.70, while [18F]FDG-PET yielded a value of 0.93. CONCLUSION rBGM and Naa/mI in the PCC were positively correlated in patients with MCI and AD. [18F]FDG-PET had greater accuracy than MRS for discriminating AD patients from controls.

scholarly journals Functional neuroimaging using F-18 FDG PET/CT in amnestic mild cognitive impairment: A preliminary study

2013 ◽  
Vol 28 (3) ◽  
pp. 129 ◽  
Author(s):  
Madhavi Tripathi ◽  
Manjari Tripathi ◽  
Abhinav Jaimini ◽  
Suman Kushwaha ◽  
Rajnish Sharma ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Fdg Pet ◽  
Functional Neuroimaging ◽  
Amnestic Mild Cognitive Impairment ◽  
Pet Ct ◽  
Preliminary Study ◽  
Fdg Pet Ct

scholarly journals Level of Executive Function Influences Verbal Memory in Amnestic Mild Cognitive Impairment and Predicts Prefrontal and Posterior Cingulate Thickness

2009 ◽  
Vol 20 (6) ◽  
pp. 1305-1313 ◽  
Author(s):  
Yu-Ling Chang ◽  
Mark W. Jacobson ◽  
Christine Fennema-Notestine ◽  
Donald J. Hagler ◽  
Robin G. Jennings ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Executive Function ◽  
Mild Cognitive Impairment ◽  
Verbal Memory ◽  
Amnestic Mild Cognitive Impairment ◽  
Posterior Cingulate

scholarly journals Comparison of MR Perfusion and FDG-PET Brain Studies in Patients With Alzheimer’s Disease and Amnestic Mild Cognitive Impairment

2022 ◽  
Author(s):  
Aleksandra Wabik ◽  
Elżbieta Trypka ◽  
Joanna Bladowska ◽  
Mikołaj Statkiewicz ◽  
Marek Sąsiadek ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Fdg Pet ◽  
Cerebral Blood Volume ◽  
Amnestic Mild Cognitive Impairment ◽  
Dynamic Susceptibility ◽  
Dynamic Susceptibility Contrast ◽  
Dsc Mri

Abstract Background: The aim of this study was to compare Dynamic Susceptibility Contrast Enhanced MRI (DSC-MRI) and PET with flurodeoxyglucose (FDG-PET) in the diagnosis of Alzheimer’s Disease (AD) and amnestic Mild Cognitive Impairment (aMCI).Methods: Age and sex matched 27 patients with AD, 39 with aMCI and 16 controls underwent brain DSC-MRI followed by FDG-PET. Values of relative Cerebral Blood Volume (rCBV) and rCBV z-scores from frontal, temporal, parietal and PCG cortices were correlated with the rate of glucose metabolism from PET. Sensitivity, specificity and accuracy of DSC-MRI and FDG-PET in the diagnosis of AD and aMCI were assessed and compared.Results: In AD hypoperfusion was found within all examined locations, while in aMCI in both parietal and temporal cortices and left PCG. FDG-PET showed the greatest hypometabolism in parietal, temporal and left PCG regions in both AD and aMCI. FDG-PET was more accurate in distinguishing aMCI from controls than DSC-MRI. In AD and combined group (AD + aMCI ) there were numerous correlations between DSC-MRI and FDG-PET results. Conclusions: In AD the patterns of hypoperfusion and glucose hypometabolism are similar thus DSC-MRI may be a competitive method to FDG-PET. FDG-PET is a more accurate method in the diagnosis of aMCI.

Clinical, Neuropsychological, and Neuroimaging Characteristics of Amyloid-positive vs. Amyloid-negative Patients with Clinically Diagnosed Alzheimer’s Disease and Amnestic Mild Cognitive Impairment

2021 ◽  
Vol 18 ◽  
Author(s):  
Yue Wang ◽  
Fanghua Lou ◽  
Yonggang Li ◽  
Fang Liu ◽  
Ying Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Fdg Pet ◽  
Verbal Learning ◽  
Amnestic Mild Cognitive Impairment ◽  
Amyloid Deposition ◽  
Metabolic Pattern ◽  
Affective Symptoms

Background: A significant proportion of patients with clinically diagnosed Alzheimer’s disease (AD) and an even higher proportion of patients with amnestic mild cognitive impairment (aMCI) do not show evidence of amyloid deposition on positron emission tomography (PET) with amyloid-binding tracers such as 11C-labeled Pittsburgh Compound B (PiB). Objective: This study aimed to identify clinical, neuropsychological and neuroimaging factors that might suggest amyloid neuropathology in patients with clinically suspected AD or aMCI. Methods: Forty patients with mild to moderate AD and 23 patients with aMCI who were clinically diagnosed in our memory clinic and had PiB PET scans were included. Clinical, neuropsychologi- cal, and imaging characteristics, such as medial temporal lobe atrophy (MTA) and white matter hy- perintensities (WMH) on MRI and metabolic pattern on 18F-labeled fluorodeoxyglucose (FDG) PET, were compared between patients with PiB positive and negative PET results for AD, aMCI, and all subjects combined, respectively. Results: Compared with PiB positive patients, PiB negative patients had a higher prevalence of hy- pertension history, better performance on the Mini-Mental State Examination, the Rey Auditory Verbal Learning Test, and the Judgement of Line Orientation, lower score of MTA, and were less likely to have temporoparietal-predominant hypometabolism on FDG PET. Affective symptoms were less common in PiB negative patients diagnosed with AD, and the Animal Fluency Test score was higher in PiB negative patients diagnosed with aMCI. Conclusion: : In patients with clinically diagnosed AD or aMCI, absence of a history of hyperten- sion, deficits in verbal learning and memory, visuospatial function, semantic verbal fluency, pres- ence of affective symptoms, MTA on MRI, and temporoparietal hypometabolism on FDG PET suggested amyloid deposition in the brain.

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