scholarly journals Treatment with D3 Removes Amyloid Deposits, Reduces Inflammation, and Improves Cognition in Aged AβPP/PS1 Double Transgenic Mice

2013 ◽  
Vol 34 (3) ◽  
pp. 609-620 ◽  
Author(s):  
Thomas van Groen ◽  
Inga Kadish ◽  
Susanne Aileen Funke ◽  
Dirk Bartnik ◽  
Dieter Willbold
Keyword(s):  
Transgenic Mice ◽  
Amyloid Deposits ◽  
Double Transgenic Mice

Modulation of T-Cell Functions in KIR2DL3 (CD158b) Transgenic Mice

Blood ◽  
1999 ◽  
Vol 94 (7) ◽  
pp. 2396-2402 ◽  
Author(s):  
Anna Cambiaggi ◽  
Sylvie Darche ◽  
Sophie Guia ◽  
Philippe Kourilsky ◽  
Jean-Pierre Abastado ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Transgenic Mice ◽  
T Cell Activation ◽  
Cell Activation ◽  
Killer Cell ◽  
In Vitro Proliferation ◽  
Cell Functions ◽  
Double Transgenic Mice

In humans, a minor subset of T cells express killer cell Ig-like receptors (KIRs) at their surface. In vitro data obtained with KIR+ β and γδ T-cell clones showed that engagement of KIR molecules can extinguish T-cell activation signals induced via the CD3/T-cell receptor (TCR) complex. We analyzed the T-cell compartment in mice transgenic for KIR2DL3 (Tg-KIR2DL3), an inhibitory receptor for HLA-Cw3. As expected, mixed lymphocyte reaction and anti-CD3 monoclonal antibody (MoAb)-redirected cytotoxicity exerted by freshly isolated splenocytes can be inhibited by engagement of transgenic KIR2DL3 molecules. In contrast, antigen and anti-CD3 MoAb-induced cytotoxicity exerted by alloreactive cytotoxic T lymphocytes cannot be inhibited by KIR2DL3 engagement. In double transgenic mice, Tg-KIR2DL3 × Tg-HLA-Cw3, no alteration of thymic differentiation could be documented. Immunization of double transgenic mice with Hen egg white lysozime (HEL) or Pigeon Cytochrome-C (PCC) was indistinguishable from immunization of control mice, as judged by recall antigen-induced in vitro proliferation and TCR repertoire analysis. These results indicate that KIR effect on T cells varies upon cell activation stage and show unexpected complexity in the biological function of KIRs in vivo.

scholarly journals Evidence for Premature Lipid Raft Aging in APP/PS1 Double-Transgenic Mice, a Model of Familial Alzheimer Disease

2012 ◽  
Vol 71 (10) ◽  
pp. 868-881 ◽  
Author(s):  
Noemí Fabelo ◽  
Virginia Martín ◽  
Raquel Marín ◽  
Gabriel Santpere ◽  
Ester Aso ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Transgenic Mice ◽  
Lipid Raft ◽  
Familial Alzheimer Disease ◽  
Double Transgenic Mice

Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic mice

2003 ◽  
Vol 14 (3) ◽  
pp. 318-327 ◽  
Author(s):  
Jun Wang ◽  
Heikki Tanila ◽  
Jukka Puoliväli ◽  
Inga Kadish ◽  
Thomas van Groen
Keyword(s):  
Gender Differences ◽  
Transgenic Mice ◽  
Double Transgenic Mice

Skewed Abrogation of Tolerance to a Neo Self-Antigen in Double-Transgenic Mice Coexpressing the Antigen with Interleukin-1β or Interferon-γ

2001 ◽  
Vol 207 (1) ◽  
pp. 6-12 ◽  
Author(s):  
Meifen Zhang ◽  
Atsuki Fukushima ◽  
Barbara P. Vistica ◽  
Stephen J. Kim ◽  
Lang Hung ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Interferon Γ ◽  
Interleukin 1Β ◽  
Double Transgenic Mice ◽  
Self Antigen

The beneficial effects of dietary grape supplementation on improving cognitive deficits in APP/PS1 double transgenic mice

2018 ◽  
Vol 49 ◽  
pp. 224-234 ◽  
Author(s):  
Kangliang Sheng ◽  
Shanshan Shui ◽  
Ling Yan ◽  
Junjie Yu ◽  
Guang Hao ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Cognitive Deficits ◽  
Beneficial Effects ◽  
Double Transgenic Mice

Self-Tolerance in B-Cells from Different Lines of Lysozyme Double-Transgenic Mice

1989 ◽  
pp. 377-384 ◽  
Author(s):  
A. Basten ◽  
R. A. Brink ◽  
D. Y. Mason ◽  
J. Crosbie ◽  
C. C. Goodnow
Keyword(s):  
B Cells ◽  
Transgenic Mice ◽  
Self Tolerance ◽  
Double Transgenic Mice

scholarly journals Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease

2002 ◽  
Vol 99 (22) ◽  
pp. 13990-13995 ◽  
Author(s):  
B. Urbanc ◽  
L. Cruz ◽  
R. Le ◽  
J. Sanders ◽  
K. H. Ashe ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Amyloid Deposits ◽  
Neurotoxic Effects
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