Skewed Abrogation of Tolerance to a Neo Self-Antigen in Double-Transgenic Mice Coexpressing the Antigen with Interleukin-1β or Interferon-γ

2001 ◽  
Vol 207 (1) ◽  
pp. 6-12 ◽  
Author(s):  
Meifen Zhang ◽  
Atsuki Fukushima ◽  
Barbara P. Vistica ◽  
Stephen J. Kim ◽  
Lang Hung ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Interferon Γ ◽  
Interleukin 1Β ◽  
Double Transgenic Mice ◽  
Self Antigen

scholarly journals Chronic Hepatitis in Interferon-γ Transgenic Mice Is Associated With Elevated CPP32-Like Activity and Interleukin-1β-Converting Enzyme Activity Suppression

1999 ◽  
Vol 79 (3) ◽  
pp. 289-294 ◽  
Author(s):  
Okamoto Toshihiro ◽  
Nakano Yoshihisa ◽  
Yamakawa Tomio ◽  
Hara Kaoru ◽  
Yamamura Ken-Ichi ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Chronic Hepatitis ◽  
Transgenic Mice ◽  
Interferon Γ ◽  
Interleukin 1Β ◽  
Converting Enzyme

scholarly journals Breakdown of Tolerance to a Neo-Self Antigen in Double Transgenic Mice in Which B Cells Present the Antigen

2000 ◽  
Vol 164 (9) ◽  
pp. 4594-4600 ◽  
Author(s):  
Alexander F. de Vos ◽  
Atsuki Fukushima ◽  
Mark C. Lobanoff ◽  
Barbara P. Vistica ◽  
James C. Lai ◽  
...  
Keyword(s):  
B Cells ◽  
Transgenic Mice ◽  
Double Transgenic Mice ◽  
Self Antigen

Modulation of T-Cell Functions in KIR2DL3 (CD158b) Transgenic Mice

Blood ◽  
1999 ◽  
Vol 94 (7) ◽  
pp. 2396-2402 ◽  
Author(s):  
Anna Cambiaggi ◽  
Sylvie Darche ◽  
Sophie Guia ◽  
Philippe Kourilsky ◽  
Jean-Pierre Abastado ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Transgenic Mice ◽  
T Cell Activation ◽  
Cell Activation ◽  
Killer Cell ◽  
In Vitro Proliferation ◽  
Cell Functions ◽  
Double Transgenic Mice

In humans, a minor subset of T cells express killer cell Ig-like receptors (KIRs) at their surface. In vitro data obtained with KIR+ β and γδ T-cell clones showed that engagement of KIR molecules can extinguish T-cell activation signals induced via the CD3/T-cell receptor (TCR) complex. We analyzed the T-cell compartment in mice transgenic for KIR2DL3 (Tg-KIR2DL3), an inhibitory receptor for HLA-Cw3. As expected, mixed lymphocyte reaction and anti-CD3 monoclonal antibody (MoAb)-redirected cytotoxicity exerted by freshly isolated splenocytes can be inhibited by engagement of transgenic KIR2DL3 molecules. In contrast, antigen and anti-CD3 MoAb-induced cytotoxicity exerted by alloreactive cytotoxic T lymphocytes cannot be inhibited by KIR2DL3 engagement. In double transgenic mice, Tg-KIR2DL3 × Tg-HLA-Cw3, no alteration of thymic differentiation could be documented. Immunization of double transgenic mice with Hen egg white lysozime (HEL) or Pigeon Cytochrome-C (PCC) was indistinguishable from immunization of control mice, as judged by recall antigen-induced in vitro proliferation and TCR repertoire analysis. These results indicate that KIR effect on T cells varies upon cell activation stage and show unexpected complexity in the biological function of KIRs in vivo.

scholarly journals Evidence for Premature Lipid Raft Aging in APP/PS1 Double-Transgenic Mice, a Model of Familial Alzheimer Disease

2012 ◽  
Vol 71 (10) ◽  
pp. 868-881 ◽  
Author(s):  
Noemí Fabelo ◽  
Virginia Martín ◽  
Raquel Marín ◽  
Gabriel Santpere ◽  
Ester Aso ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Transgenic Mice ◽  
Lipid Raft ◽  
Familial Alzheimer Disease ◽  
Double Transgenic Mice

Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic mice

2003 ◽  
Vol 14 (3) ◽  
pp. 318-327 ◽  
Author(s):  
Jun Wang ◽  
Heikki Tanila ◽  
Jukka Puoliväli ◽  
Inga Kadish ◽  
Thomas van Groen
Keyword(s):  
Gender Differences ◽  
Transgenic Mice ◽  
Double Transgenic Mice

scholarly journals Influence of various treatment methods on the content of cytokines in saliva of patients with chronic sialadenitis

2018 ◽  
Vol 99 (4) ◽  
pp. 593-597
Author(s):  
S Z Aliev
Keyword(s):  
Comparison Group ◽  
Interleukin 2 ◽  
Interferon Γ ◽  
Interleukin 1Β ◽  
Comprehensive Treatment ◽  
Study Group ◽  
Local Immunotherapy ◽  
Chronic Sialadenitis ◽  
Cytokine Levels ◽  
Mixed Saliva

Aim. Study of the main cytokines (interleukin-1β and -2, interferon γ) in the mixed saliva from patients with chronic sialadenitis on the basic and comprehensive treatment dynamically. Methods. During the period of 2014 to 2017 we performed examination and treatment of patients with salivary gland diseases. Out of them we defined a group with chronic non-specific sialadenitis including 45 patients seen in the clinic in exacerbation. Patients in the comparison group received basic treatment. Patients in the study group additionally to conventional treatment were administered local immunotherapy. Measurement of cytokine levels in the oral fluid was performed in 45 patients with chronic sialadenitis in exacerbation and in 10 practically healthy subjects. Results. The level of interleukin-1β in saliva was found to be significantly increased before treatment (p <0.05). After the treatment interleukin-1β level in saliva decreased in both groups but most significantly this parameter decreased in the study group. After including local immunocorrection into the treatment complex dynamic decrease of interleukin-2 to 14.7±0.4 pg/ml was registered, which apparently is associated with stabilization of immune processes in the oral cavity. After the treatment conducted according to traditional scheme in the comparison group the level of interferon γ in saliva increased to 7.2±0.2 pg/ml which is 1.1 times higher than before treatment. Conclusion. In patients with chronic sialadenitis in exacerbation the level of interleukin-1β statistically significantly increases by 1. times (p <0.05), interleukin 2 - by 2.1 times (p <0.05) and the level of interferon γ decreases by 1.4 times (p <0.05) which is indicative of immunological signs of inflammatory reaction; use of local immunocorrection leads to more prominent decrease of interleukin-1β (by 20.3 vs 16.2% in comparison group; p <0.05), interleukin-2 (by 38.8 vs 26.6%; p <0.05) and increase of interferon γ (by 21.2 vs 12.5% in comparison group; p <0.05).

INTERFERON-γ AND INTERLEUKIN 4 INHIBIT INTERLEUKIN 1β-INDUCED DELAYED PROSTAGLANDIN E2GENERATION THROUGH SUPPRESSION OF CYCLOOXYGENASE-2 EXPRESSION IN HUMAN FIBROBLASTS

Cytokine ◽  
2000 ◽  
Vol 12 (6) ◽  
pp. 603-612 ◽  
Author(s):  
Yoshinori Hayashi ◽  
Makoto Kobayashi ◽  
Hiroshi Kuwata ◽  
Gen-ichi Atsumi ◽  
Katsutoshi Deguchi ◽  
...  
Keyword(s):  
Human Fibroblasts ◽  
Interferon Γ ◽  
Cyclooxygenase 2 ◽  
Interleukin 1Β ◽  
Interleukin 4
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