Engineering Platform as Integrated Software for Model Mediated Research

2021 ◽  
Author(s):  
László Horváth ◽  
Levente Kovács
Keyword(s):  
Applied Mathematics ◽  
Complex Model ◽  
Model Systems ◽  
Research Project ◽  
Engineering Software ◽  
Wide Range ◽  
Applied Informatics ◽  
Innovation Cycle ◽  
Research Integration ◽  
Integrated Software

Engineering software platform supports engineering activities in continuously widening disciplinary area of complex systems operated industrial and commercial products and other engineering achievements. Engineering activities increasingly include research extending the conventional product lifecycle engineering to the whole innovation cycle. Comprehensive engineering platform comprises wide range of integrated software solutions to manage complex model systems to represent situation controlled autonomous products and offers all software solutions necessary for the integrated innovation and life cycle. By now, engineering platforms are amongst the largest and most complex applications of advanced software. This paper reports recent contributions to concept and methodology of research integration representations for engineering model systems using research capabilities of engineering platform. First, concept on model organized research project (MORP) is introduced. MORP is a new model system based concept of research project which is managed using capabilities of software organized in these platforms. MORP relies on the formerly defined concept of model mediated research (MMR) which is extended to research in situation control of autonomous functions of the represented systems operated engineering achievements recognizing that situation control reorganizes engineering related research to a great extent. Following this, connection of MORP with software which provides situation based control for physical execution in cyber physical system (CPS) is analyzed and discussed. The MMR based MORP is about pilot projecting at the recently established virtual research laboratory (VRL) at the Doctoral School of Applied Informatics and Applied Mathematics (DSAIAM) at the Óbuda University.

scholarly journals Quantitative linear dichroism imaging of molecular processes in living cells made simple by open software tools

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Alexey Bondar ◽  
Olga Rybakova ◽  
Josef Melcr ◽  
Jan Dohnálek ◽  
Petro Khoroshyy ◽  
...  
Keyword(s):  
Biological Systems ◽  
Linear Dichroism ◽  
Quantitative Information ◽  
Living Cells ◽  
Software Tools ◽  
Model Systems ◽  
Membrane Properties ◽  
Polarization Microscopy ◽  
Molecular Processes ◽  
Wide Range

AbstractFluorescence-detected linear dichroism microscopy allows observing various molecular processes in living cells, as well as obtaining quantitative information on orientation of fluorescent molecules associated with cellular features. Such information can provide insights into protein structure, aid in development of genetically encoded probes, and allow determinations of lipid membrane properties. However, quantitating and interpreting linear dichroism in biological systems has been laborious and unreliable. Here we present a set of open source ImageJ-based software tools that allow fast and easy linear dichroism visualization and quantitation, as well as extraction of quantitative information on molecular orientations, even in living systems. The tools were tested on model synthetic lipid vesicles and applied to a variety of biological systems, including observations of conformational changes during G-protein signaling in living cells, using fluorescent proteins. Our results show that our tools and model systems are applicable to a wide range of molecules and polarization-resolved microscopy techniques, and represent a significant step towards making polarization microscopy a mainstream tool of biological imaging.

scholarly journals Regulation of Cytochrome c Oxidase by Natural Compounds Resveratrol, (–)-Epicatechin, and Betaine

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1346
Author(s):  
Icksoo Lee
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Model Systems ◽  
Health Improvement ◽  
Published Data ◽  
Mitochondrial Electron Transport Chain ◽  
Naturally Occurring ◽  
Transport Chain ◽  
Wide Range ◽  
Experimental Model Systems

Numerous naturally occurring molecules have been studied for their beneficial health effects. Many compounds have received considerable attention for their potential medical uses. Among them, several substances have been found to improve mitochondrial function. This review focuses on resveratrol, (–)-epicatechin, and betaine and summarizes the published data pertaining to their effects on cytochrome c oxidase (COX) which is the terminal enzyme of the mitochondrial electron transport chain and is considered to play an important role in the regulation of mitochondrial respiration. In a variety of experimental model systems, these compounds have been shown to improve mitochondrial biogenesis in addition to increased COX amount and/or its enzymatic activity. Given that they are inexpensive, safe in a wide range of concentrations, and effectively improve mitochondrial and COX function, these compounds could be attractive enough for possible therapeutic or health improvement strategies.

scholarly journals Personality trait differences across types of entrepreneurs: a systematic literature review

2021 ◽  
Author(s):  
Florentine U. Salmony ◽  
Dominik K. Kanbach
Keyword(s):  
Literature Review ◽  
Personality Traits ◽  
Systematic Literature Review ◽  
Empirical Studies ◽  
Academic Research ◽  
Future Research ◽  
Rural Farmers ◽  
Start Up ◽  
Wide Range ◽  
Research Integration

AbstractThe personality traits that define entrepreneurs have been of significant interest to academic research for several decades. However, previous studies have used vastly different definitions of the term “entrepreneur”, meaning their subjects have ranged from rural farmers to tech-industry start-up founders. Consequently, most research has investigated disparate sub-types of entrepreneurs, which may not allow for inferences to be made regarding the general entrepreneurial population. Despite this, studies have frequently extrapolated results from narrow sub-types to entrepreneurs in general. This variation in entrepreneur samples reduces the comparability of empirical studies and calls into question the reviews that pool results without systematic differentiation between sub-types. The present study offers a novel account by differentiating between the definitions of “entrepreneur” used in studies on entrepreneurs’ personality traits. We conduct a systematic literature review across 95 studies from 1985 to 2020. We uncover three main themes across the previous studies. First, previous research applied a wide range of definitions of the term “entrepreneur”. Second, we identify several inconsistent findings across studies, which may at least partially be due to the use of heterogeneous entrepreneur samples. Third, the few studies that distinguished between various types of entrepreneurs revealed differences between them. Our systematic differentiation between entrepreneur sub-types and our research integration offer a novel perspective that has, to date, been widely neglected in academic research. Future research should use clearly defined entrepreneurial samples and conduct more systematic investigations into the differences between entrepreneur sub-types.

scholarly journals Modelling mechanical properties of the multilayer composite materials with the polyamide core

2018 ◽  
Vol 157 ◽  
pp. 02052 ◽  
Author(s):  
Krzysztof Talaśka ◽  
Dominik Wojtkowiak
Keyword(s):  
Mechanical Properties ◽  
Composite Materials ◽  
High Strength ◽  
Conveyor Belt ◽  
Complex Model ◽  
Multilayer Composite ◽  
Thermosetting Polymers ◽  
Wide Range ◽  
Belt Conveyors ◽  
Polyamide Film

Due to the wide range of application for belt conveyors, engineers look for many different combinations of mechanical properties of conveyor and transmission belts. It can be made by creating multilayer or fibre reinforced composite materials from base thermoplastic or thermosetting polymers. In order to gain high strength with proper elasticity and friction coefficient, the core of the composite conveyor belt is made of polyamide film core, which can be combined with various types of polymer fabrics, films or even rubbers. In this paper authors show the complex model of multilayer composite belt with the polyamide core, which can be used in simulation analyses. The following model was derived based on the experimental research, which consisted of tensile, compression and shearing tests. In order to achieve the most accurate model, proper simulations in ABAQUS were made and then the results were compared with empirical mechanical characteristics of a conveyor belt. The main goal of this research is to fully describe the perforation process of conveyor and transmission belts for vacuum belt conveyors. The following model will help to develop design briefs for machines used for mechanical perforation.

scholarly journals Rapid prototyping of a complex model for the manufacture of plaster molds for slip casting ceramic

Cerâmica ◽  
2014 ◽  
Vol 60 (356) ◽  
pp. 465-470 ◽  
Author(s):  
D. P. C. Velazco ◽  
E. F. Sancet ◽  
F. Urbaneja ◽  
M. Piccico ◽  
M. F. Serra ◽  
...  
Keyword(s):  
Rapid Prototyping ◽  
New Technologies ◽  
Slip Casting ◽  
Complex Model ◽  
Computer Assisted ◽  
Plaster Mold ◽  
Digital Format ◽  
Wide Range ◽  
3D Scanners ◽  
Ceramic Manufacturing

Computer assisted designing (CAD) is well known for several decades and employed for ceramic manufacturing almost since the beginning, but usually employed in the first part of the projectual ideation processes, neither in the prototyping nor in the manufacturing stages. The rapid prototyping machines, also known as 3D printers, have the capacity to produce in a few hours real pieces using plastic materials of high resistance, with great precision and similarity with respect to the original, based on unprecedented digital models produced by means of modeling with specific design software or from the digitalization of existing parts using the so-called 3D scanners. The main objective of the work is to develop the methodology used in the entire process of building a part in ceramics from the interrelationship between traditional techniques and new technologies for the manufacture of prototypes. And to take advantage of the benefits that allow us this new reproduction technology. The experience was based on the generation of a complex piece, in digital format, which served as the model. A regular 15 cm icosahedron presented features complex enough not to advise the production of the model by means of the traditional techniques of ceramics (manual or mechanical). From this digital model, a plaster mold was made in the traditional way in order to slip cast clay based slurries, freely dried in air and fired and glazed in the traditional way. This experience has shown the working hypothesis and opens up the possibility of new lines of work to academic and technological levels that will be explored in the near future. This technology provides a wide range of options to address the formal aspect of a part to be performed for the field of design, architecture, industrial design, the traditional pottery, ceramic art, etc., which allow you to amplify the formal possibilities, save time and therefore costs when drafting the necessary and appropriate matrixes to each requirement.

scholarly journals Microstructure representation of snow in coupled snowpack and microwave emission models

2016 ◽  
Author(s):  
Melody Sandells ◽  
Richard Essery ◽  
Nick Rutter ◽  
Leanne Wake ◽  
Leena Leppänen ◽  
...  
Keyword(s):  
Brightness Temperature ◽  
Microstructure Evolution ◽  
Microwave Emission ◽  
Model Systems ◽  
Research Centre ◽  
Emission Model ◽  
Mean Error ◽  
Scale Factors ◽  
Wide Range ◽  
Emission Models

Abstract. This is the first study to encompass a wide range of coupled snow evolution and microwave emission models in a common modelling framework in order to generalise the link between snowpack microstructure predicted by the snow evolution models and microstructure required to reproduce observations of brightness temperature as simulated by snow emission models. Brightness temperatures at 18.7 and 36.5 GHz were simulated by 1323 ensemble members, formed from 63 Jules Investigation Model snowpack simulations, three microstructure evolution functions and seven microwave emission model configurations. Two years of meteorological data from the Sodankylä Arctic Research Centre, Finland were used to drive the model over the 2011–2012 and 2012–2013 winter periods. Comparisons between simulated snow grain diameters and field measurements with an IceCube instrument showed that the evolution functions from SNTHERM simulated snow grain diameters that were too large (mean error 0.12 to 0.16 mm), whereas MOSES and SNICAR microstructure evolution functions simulated grain diameters that were too small (mean error −0.16 to −0.24 mm for MOSES, and −0.14 to −0.18 mm for SNICAR). No model (HUT, MEMLS or DMRT-ML) provided a consistently good fit across all frequencies and polarizations. The smallest absolute values of mean bias in brightness temperature over a season for a particular frequency and polarization ranged from 0.9 to 7.2 K. Optimal scaling factors for the snow microstructure were presented to compare compatibility between snowpack model microstructure and emission model microstructure. Scale factors ranged between 0.3 for the SNTHERM-Empirical MEMLS model combination (2011–2012), and 5.0 or greater when considering non-sticky particles in DMRT-ML in conjunction with MOSES or SNICAR microstructure (2012–2013). Differences in scale factors between microstructure models were generally greater than the differences between microwave emission models, suggesting that more accurate simulations in coupled snowpack-microwave model systems will be achieved primarily through improvements in the snowpack microstructure representation, followed by improvements in the emission models. Other snowpack parameterisations in the snowpack model, mainly densification, led to a mean brightness temperature difference of 11 K when the JIM ensemble was applied to the MOSES microstructure and empirical MEMLS emission model for the 2011–2012 season. Consistency between snowpack microstructure and microwave emission models, and the choice of snowpack densification algorithms should be considered in the design of snow mass retrieval systems and microwave data assimilation systems.

scholarly journals Usability Assessment for the Enhancement of Quality of a Web Portal Interface

2019 ◽  
Vol 9 (1) ◽  
pp. 1636-1640
Keyword(s):  
Research Group ◽  
Single Point ◽  
Portal System ◽  
Web Portal ◽  
Web Based ◽  
Academic Administration ◽  
Usability Assessment ◽  
Wide Range ◽  
Applied Informatics

A web portal can be defined as a personalized, single point of access to information, resources and services covering a wide range of topic. Based on some researches, a system based on the internet can improve the work efficiency to some extent and provide all kinds of academic administration information timely. As to establish the intended function, usability is a crucial factor to be embarked on. This will ensure that the users are attracted to use the portal by increasing the relationship between the users and the portal’s interface. The Applied Informatics Research Group (AIRG) is the group assigned by the Faculty of Computer Science and Information Technology (FSKTM) to manage the Research Group Portal System (RGPS) that is the sample used in this research. The RGPS is a web-based system that allows collaboration among the users; to locate, store, use and share their knowledge. The main objective of this research is to obtain the feedbackfrom the users regarding the usability of the RGPS that is deterring them from optimizing the usage of this system. Surveys and questionnaires are used to evaluate and the output acts an input to modify the interface of the RGPS. Again, validation will be done to weight the users’ experience with the modified user interface.

scholarly journals Health Dynamics Through Psychometric Networks in Gynecology, Obstetrics, Reproductive Health And COVID-19 Research

2021 ◽  
Vol 5 (2) ◽  
Keyword(s):  
Network Analysis ◽  
Maternal Health ◽  
Reproductive Health ◽  
Clinical Importance ◽  
Complex Model ◽  
Model Systems ◽  
Health Conditions ◽  
Clinical Population ◽  
Concomitant Variables ◽  
Health Dynamics

Network analysis offers a valuable methodological and practical contribution to research in gynecology, obstetrics and reproductive health. This analysis enables clinicians to interpret and translate the information derived from their research into better integrated care in the clinical population of interest, allowing them to focus a concrete intervention based on network results, from the perspective of complex model systems. The evaluation of the network reinforces a better explanation of the functioning of various reproductive and maternal health conditions to explain how their etiological mechanisms and concomitant variables interact with each other, of major clinical importance in the current COVID-19 pandemic context.

scholarly journals Originals of operating images for generalized problems of unsteady heat conductivity

2019 ◽  
Vol 14 (4) ◽  
pp. 77-86 ◽  
Author(s):  
E. M. Kartashov
Keyword(s):  
Mathematical Models ◽  
Bessel Functions ◽  
Applied Mathematics ◽  
Operational Calculus ◽  
Polymeric Materials ◽  
Thermal Reaction ◽  
Heaviside Step Function ◽  
External Influences ◽  
Wide Range ◽  
Variable Function

A series of operating (Laplace) non-standard images, the originals of which are absent in well-known reference books on operational calculus, are considered. By reducing one of the basic images to the Riemann-Mellin contour integral for the modified Bessel functions and analyzing the corresponding inversion formula using the approaches of the complex variable function theory, an analytical form of the original original is found, which is abrupt in nature with a break point. It is shown that analytical solutions of the corresponding mathematical models using the found originals have a wave character, which is expressed by the presence of the Heaviside step function in the solutions. The latter means that at any time there is a region of physical disturbance to the point of discontinuity and an unperturbed area after the point of discontinuity. The images studied are included in the operational solutions of mathematical models in many areas of applied mathematics. physics, thermomechanics, thermal physics, in particular in the theory of thermal shock of viscoelastic bodies, in the study of the thermal reaction of solids based on the classical Maxwell-Cattaneo-Lykov-Vernott phenomenology, taking into account the final rate of heat propagation. These models are needed to study the thermal reaction of relatively new consolidated structurally sensitive polymeric materials in structures exposed to high-intensity external influences. The analytical relations obtained for the originals and the original improper integrals resulting from them, containing combinations of Bessel functions, can be used in the general methodology of constructing and applying various mathematical models in a wide range of external influences on materials in many fields of science and technology.

NESTED HIGH-RESOLUTION NOx AND PM SIMULATIONS OVER ZÜRICH

2021 ◽  
Author(s):  
Ivo Suter ◽  
Lukas Emmenegger ◽  
Dominik Brunner
Keyword(s):  
Air Pollution ◽  
Air Quality ◽  
Boundary Conditions ◽  
Meteorological Conditions ◽  
Model Systems ◽  
Multi Scale ◽  
Wide Range ◽  
The Impact ◽  
The City ◽  
Concentration Levels

<p>Reducing air pollution, which is the world's largest single environmental health risk, demands better-informed air quality policies. Consequently, multi-scale air quality models are being developed with the goal to resolve cities. One of the major challenges in such model systems is to accurately represent all large- and regional-scale processes that may critically determine the background concentration levels over a given city. This is particularly true for longer-lived species such as aerosols, for which background levels often dominate the concentration levels, even within the city. Furthermore, the heterogeneous local emissions, and complex dispersion in the city have to be considered carefully.</p><p>In this study, the impact of processes across a wide range of scales on background concentrations over Switzerland and the city of Zurich was modelled by performing one year of nested European and Swiss national COSMO-ART simulations to obtain adequate boundary conditions for gas-phase chemical, aerosol and meteorological conditions for city-resolving simulations. The regional climate chemistry model COSMO-ART (Vogel et al. 2009) was used in a 1-way coupled mode. The outer, European, domain, which was driven by chemical boundary conditions from the global MOZART model, had a 6.6 km horizontal resolution and the inner, Swiss, domain one of 2.2 km. For the city scale, a catalogue of more than 1000 mesoscale flow patterns with 100 m resolution was created with the model GRAMM, based on a discrete set of atmospheric stabilities, wind speeds and directions, accounting for the influence of land-use and topography. Finally, the flow around buildings was solved with the CFD model GRAL forced at the boundaries by GRAMM. Subsequently, Lagrangian dispersion simulations for a set of air pollutants and emission sectors (traffic, industry, ...) based on extremely detailed building and emission data was performed in GRAL. The result of this nested procedure is a library of 3-dimensional air pollution maps representative of hourly situations in Zurich (Berchet et al. 2017). From these pre-computed situations, time-series and concentration maps can be obtained by selecting situations according to observed or modelled meteorological conditions.</p><p>The results were compared to measurements from air quality monitoring network stations. Modelled concentrations of NO<sub>x</sub> and PM compared well to measurements across multiple locations, provided background conditions were considered carefully. The nested multi-scale modelling system COSMO-ART/GRAMM/GRAL can adequately reproduce local air quality and help understanding the relative contributions of local versus distant emissions, as well as fill the space between precise point measurements from monitoring sites. This information is useful for research, policy-making, and epidemiological studies particularly under the assumption that exceedingly high concentrations become more and more localised phenomenon in the future.</p>

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