Moderate red wine consumption improves hemorheological parameters in healthy volunteers

2014 ◽  
Vol 56 (1) ◽  
pp. 13-23 ◽  
Author(s):  
A. Toth ◽  
B. Sandor ◽  
J. Papp ◽  
M. Rabai ◽  
D. Botor ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Red Wine ◽  
Wine Consumption

scholarly journals The influence of moderate red wine consumption on antioxidant status and indices of oxidative stress associated with CHD in healthy volunteers

2005 ◽  
Vol 93 (2) ◽  
pp. 233-240 ◽  
Author(s):  
Catherine Tsang ◽  
Siobhan Higgins ◽  
Garry G. Duthie ◽  
Susan J. Duthie ◽  
Moira Howie ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Healthy Volunteers ◽  
Antioxidant Status ◽  
Red Wine ◽  
Conjugated Dienes ◽  
Controlled Study ◽  
Total Phenolic ◽  
Resonance Spectroscopy ◽  
Oxidised Ldl ◽  
Wine Consumption

The effects of moderate red wine consumption on the antioxidant status and indices of lipid peroxidation and oxidative stress associated with CHD were investigated. A randomised, controlled study was performed with twenty free-living healthy volunteers. Subjects in the red wine group consumed 375 ml red wine daily for 2 weeks. We measured the total concentration of phenolics and analysed the individual phenolics in the wine and plasma by HPLC with tandem MS. The antioxidant capacity of plasma was measured with electron spin resonance spectroscopy while homocysteine and fasting plasma lipids were also determined. The production of conjugated dienes and thiobarbituric acid-reactive substances (TBARS) were measured in Cu-oxidised LDL. Plasma total phenolic concentrations increased significantly after 2 weeks of daily red wine consumption (P≤0·001) and trace levels of metabolites, mainly glucuronides and methyl glucuronides of (+)-catechin and (−)-epicatechin, were detected in the plasma of the red wine group. These flavan-3-ol metabolites were not detected in plasma from the control group. The maximum concentrations of conjugated dienes and TBARS in Cu-oxidised LDL were reduced (P≤0·05) and HDL cholesterol concentrations increased (P≤0·05) following red wine consumption. The findings from the present study provide some evidence for potential protective effects of moderate consumption of red wine in healthy volunteers.

scholarly journals Metabolome-based clustering after moderate wine consumption

OENO One ◽  
2020 ◽  
Vol 54 (3) ◽  
pp. 455-467 ◽  
Author(s):  
Adelaida Esteban-Fernández ◽  
Clara Ibañez ◽  
Carolina Simó ◽  
Begoña Bartolomé ◽  
Victoria Moreno Arribas
Keyword(s):  
Clinical Trials ◽  
Healthy Volunteers ◽  
Red Wine ◽  
Nutritional Interventions ◽  
Phenolic Metabolites ◽  
Wine Consumption ◽  
Wine Polyphenols ◽  
Relative Production ◽  
First Time ◽  
Metabolomic Approach

Grouping individuals according to their metabolic capacities (metabotyping) has caused a shift from individualised to grouped treatments for the optimisation of nutritional interventions. Several studies have reported a stratification of patients into metabolic clusters after the intake of certain foods, of which polyphenols seem to be mostly associated with metabotypes. Despite this, there is a lack of metabotyping studies regarding wine consumption. In this context, the human urinary metabolome of healthy volunteers (n=41) was explored by means of a non-targeted metabolomic approach after an intervention with red wine (250 mL/day, 28 days). Three clusters of volunteers based on their relative production of phenolic metabolites were perceived , and the compounds responsible for this clustering were identified. To our knowledge, this is the first time that different urinary metabotypes have been described in healthy volunteers after moderate red wine consumption. Our findings suggest that stratification of individuals in clinical trials according to their metabotype is necessary to fully understand the health effects of wine polyphenols.

scholarly journals Moderate Wine Consumption Reduces Faecal Water Cytotoxicity in Healthy Volunteers

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2716
Author(s):  
Irene Zorraquín-Peña ◽  
Dolores González de Llano ◽  
Alba Tamargo ◽  
M. Victoria Moreno-Arribas ◽  
Begoña Bartolomé
Keyword(s):  
Cell Viability ◽  
Healthy Volunteers ◽  
Cell Lines ◽  
Red Wine ◽  
Favourable Effect ◽  
Control Group ◽  
Gut Health ◽  
Wine Consumption ◽  
Hct 116 ◽  
Assay Conditions

There are some studies that suggest that moderate consumption of wine, as part of a healthy and balanced diet, has a favourable effect on intestinal health. This study evaluates the effect of moderate wine consumption on faecal water (FW) cytotoxicity as a parameter of gut health. To that end, faecal samples before and after a red wine intervention study (250 mL of wine/day, 4 weeks) in healthy volunteers (n = 8) and in a parallel control group (n = 3) were collected and assayed for in vitro FW cytotoxicity. Two reference compounds, phenol and p-cresol, were used for assessing the cytotoxicity assays using two colon epithelial cell lines (HT-29 and HCT 116) and different assay conditions (FW dilution and incubation time). For the two cell lines and all assay conditions, the means of percentage cell viability were higher (lower cytotoxicity) for samples collected after the red wine intervention than for those collected before, although significant (p < 0.05) differences were only found in certain assay conditions for both cell lines. Significant positive correlations between the percentage cell viability and the contents of some faecal metabolites (short-chain fatty acids (SCFA) and phenolic acids (PA)) were found for the more resistant cell line (HCT 116), suggesting that the reduction in FW cytotoxicity observed after moderate red wine consumption was related to the production of microbial-derived metabolites such as SCFA and PA, whose faecal contents have been shown to increase after wine consumption. FW cytotoxicity can be deemed as a holistic biomarker that involves diet, gut microbiota and host.

Moderate red wine consumption in healthy volunteers reduced plasma clearance of apolipoprotein AII

1999 ◽  
Vol 29 (5) ◽  
pp. 387-394 ◽  
Author(s):  
Gottrand ◽  
Beghin ◽  
Duhal ◽  
Lacroix ◽  
Bonte ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Plasma Clearance ◽  
Red Wine ◽  
Wine Consumption

Element and redox homeostasis in rats after red wine consumption

2011 ◽  
Vol 49 (05) ◽  
Author(s):  
K Szentmihályi ◽  
Z May ◽  
H Fébel ◽  
G Bekő ◽  
A Blázovics
Keyword(s):  
Red Wine ◽  
Redox Homeostasis ◽  
Wine Consumption

Modulation of rat cerebellum oxidative status by prolonged red wine consumption

2008 ◽  
Vol 13 (3-4) ◽  
pp. 337-344 ◽  
Author(s):  
Marco Assunção ◽  
Maria João Santos-Marques ◽  
Victor de Freitas ◽  
Manuel Maria Paula-Barbosa ◽  
Félix Carvalho
Keyword(s):  
Red Wine ◽  
Oxidative Status ◽  
Wine Consumption ◽  
Rat Cerebellum

scholarly journals Effect of acute and chronic red wine consumption on lipopolysaccharide concentrations

2013 ◽  
Vol 97 (5) ◽  
pp. 1053-1061 ◽  
Author(s):  
Mercedes Clemente-Postigo ◽  
Maria Isabel Queipo-Ortuño ◽  
Maria Boto-Ordoñez ◽  
Leticia Coin-Aragüez ◽  
Maria del Mar Roca-Rodriguez ◽  
...  
Keyword(s):  
Red Wine ◽  
Wine Consumption

Abstract 3785: Red Wine Consumption Increases Circulating Endothelial Progenitor Cells and Improves Endothelial Function in Obese Type II Diabetics

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Catherine L Seck ◽  
Jochen Mueller-Ehmsen ◽  
Gerhard Kreuter ◽  
Karl-Heinz Hauser ◽  
Daniela Braun ◽  
...  
Keyword(s):  
Brachial Artery ◽  
Type Ii Diabetes ◽  
Red Wine ◽  
Obese Patients ◽  
Type Ii ◽  
Drinking Period ◽  
Wine Consumption ◽  
Cd34 Cells ◽  
Flow Mediated Dilatation ◽  
Artery Flow

Objective: Cardiovascular risk factors are associated with decreased levels of circulating progenitor cells (CPC). The aim of this study was to determine whether the moderate consumption of red wine leads to an increase of CPCs. Methods: CD34 positive and CD133/CD34 as well as CD117/CD34 double positive cells were measured by FACS analysis in peripheral blood of 15 obese patients suffering from type II diabetes with stable oral drug treatment (67.3 ± 2.3 years, BMI 32.3 ± 0.5 kg/ m 2 ) prior to and after a six week period of drinking two units (300 ml) of red wine (Lemberger Classic, Württemberg, Germany). The drinking period was anticipated by a four week fasting period, in which no alcohol consumption was allowed at all. In addition, brachial artery flow mediated dilatation was determined prior to and after the drinking period. Results: The six week drinking period had no effect on BMI, systolic and diastolic blood pressure, blood glucose levels, HbA1c-values and liver enzymes. There was a non-significant drop in LDL cholesterol, but no change in HDL cholesterol. Concerning CPCs, the following alterations were observed: CD34+ cells increased from 171 ± 22 to 354 ± 28 per million leucocytes. Within the CD34+ cells, the percentage of CD133+ cells increased from 30.8 ± 5.7 % to 53.1 ± 3.3 %, and the percentage of CD117+ cells increased from 38.1 ± 5.8 % to 57.5 ± 4.6 % (p<0.05 for all parameters). Brachial artery flow mediated dilatation increased from 5.57 ± 0.74 % to 11.13 ± 1.34 % (p<0.05) in response to six weeks of red wine consumption. Nitroglycerin mediated brachial artery dilatation increased from 7.45 ± 1.09 % to 11.31 ± 1.09 % (p<0.05). Conclusion: In obese patients suffering from type II diabetes, moderate consumption of red wine leads to a significant improvement of circulating progenitor cell count and endothelial function. No adverse effects of wine consumption on metabolic and cardiovascular parameters were observed.

scholarly journals Red wine consumption, coronary calcification, and long-term clinical evolution

2018 ◽  
Vol 51 (12) ◽  
Author(s):  
P.L. da Luz ◽  
D. Favarato ◽  
E.H. Moriguchi ◽  
W. de Carli ◽  
N. Bruscato ◽  
...  
Keyword(s):  
Red Wine ◽  
Coronary Calcification ◽  
Wine Consumption ◽  
Clinical Evolution
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