Atherosclerosis, inflammatory factor changes, cognitive disorder and vascular endothelial functions in patients with different grades of leukoaraiosis

2020 ◽  
Vol 73 (4) ◽  
pp. 591-597 ◽  
Author(s):  
Lirong Lin ◽  
Yaxuan Zhang ◽  
Qingxin Zeng ◽  
Ligong Lin ◽  
Xiaoli Geng ◽  
...  
Keyword(s):  
Cognitive Disorder ◽  
Inflammatory Factor ◽  
Vascular Endothelial ◽  
Endothelial Functions

scholarly journals Interleukin-17A Triggers the Release of Platelet-Derived Factors Driving Vascular Endothelial Cells toward a Pro-Angiogenic State

Cells ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1855
Author(s):  
Aikaterini Gatsiou ◽  
Kateryna Sopova ◽  
Alexandros Tselepis ◽  
Konstantinos Stellos
Keyword(s):  
Endothelial Cells ◽  
Immune Cell ◽  
Vascular Endothelial Cells ◽  
Interleukin 2 ◽  
Cell Subset ◽  
Aortic Ring ◽  
Inflammatory Factor ◽  
Vascular Endothelial ◽  
Monocyte Chemoattractant Protein 1 ◽  
Vascular Regeneration

Platelets comprise a highly interactive immune cell subset of the circulatory system traditionally known for their unique haemostatic properties. Although platelets are considered as a vault of growth factors, cytokines and chemokines with pivotal role in vascular regeneration and angiogenesis, the exact mechanisms by which they influence vascular endothelial cells (ECs) function remain underappreciated. In the present study, we examined the role of human IL-17A/IL-17RA axis in platelet-mediated pro-angiogenic responses. We reveal that IL-17A receptor (IL-17RA) mRNA is present in platelets transcriptome and a profound increase is documented on the surface of activated platelets. By quantifying the protein levels of several factors, involved in angiogenesis, we identified that IL-17A/IL17RA axis selectively induces the release of vascular endothelial growth factor, interleukin -2 and -4, as well as monocyte chemoattractant protein -1 from treated platelets. However, IL-17A exerted no effect on the release of IL-10, an anti-inflammatory factor with potentially anti-angiogenic properties, from platelets. Treatment of human endothelial cell two-dimensional tubule networks or three-dimensional spheroid and mouse aortic ring structures with IL-17A-induced platelet releasate evoked pro-angiogenic responses of ECs. Our findings suggest that IL-17A may critically affect platelet release of pro-angiogenic factors driving ECs towards a pro-angiogenic state.

scholarly journals P66Shc and vascular endothelial function

2019 ◽  
Vol 39 (4) ◽  
Author(s):  
Santosh Kumar
Keyword(s):  
Endothelial Function ◽  
Vascular Endothelium ◽  
Physiological Function ◽  
Vascular Endothelial ◽  
Molecular Signaling ◽  
Vascular Endothelial Function ◽  
Pathological Conditions ◽  
Endothelial Functions ◽  
Active Research ◽  
Oxidative Function

Abstract Dysfunctional endothelium is an early change in vasculature known to be associated with atherosclerosis. Among many regulators of vascular endothelial function, p66Shc has consistently been shown to mediate endothelial dysfunction. Over more than three decades of active research in the field of the physiological function of p66Shc, regulation of vascular endothelial functions has emerged as one of the most robust effects in a broad range of pathological conditions including hyperlipidemia, diabetes, and aging. A significant understanding has been developed with respect to the molecular signaling regulating the oxidative function of p66Shc in endothelial cells and its targets and regulators. In addition, novel regulatory modifications of p66Shc controlling its oxidative function, subcellular distribution, and stability have also been reported. This review will focus on summarizing the molecular signaling regulating the oxidative function of p66Shc and its role in vascular endothelium.

scholarly journals COX2 Enhances Neovascularization of Inflammatory Tenocytes Through the HIF-1α/VEGFA/PDGFB Pathway

2021 ◽  
Vol 9 ◽  
Author(s):  
Bin Deng ◽  
Pu Xu ◽  
Bingyu Zhang ◽  
Qing Luo ◽  
Guanbin Song
Keyword(s):  
Growth Factor ◽  
Trichostatin A ◽  
Critical Role ◽  
Tendon Injuries ◽  
Luciferase Reporter ◽  
Inflammatory Factor ◽  
Vascular Endothelial ◽  
Expression Levels ◽  
Transcriptional Targets ◽  
Gene Assay

Tendon injuries are among the most challenging in orthopedics. During the early tendon repair, new blood vessel formation is necessary. However, excessive angiogenesis also exacerbates scar formation, leading to pain and dysfunction. A significantly worse outcome was associated with higher expression levels of hypoxia-inducible factor-1 alpha (HIF-1α), and its transcriptional targets vascular endothelial growth factor A (VEGFA) and platelet-derived growth factor B (PDGFB), but the underlying molecular mechanisms remain unclear. In this study, lipopolysaccharide (LPS) was used to induce an inflammatory response in tenocytes. LPS increased the tenocytes’ inflammatory factor COX2 expression and activated the HIF-1α/VEGFA/PDGFB pathway. Moreover, the conditioned medium from the tenocytes boosted rat aortic vascular endothelial cell (RAOEC) angiogenesis. Furthermore, Trichostatin A (TSA), an inhibitor of histone deacetylase, was used to treat inflammatory tenocytes. The expression levels of HIF-1α and its transcriptional targets VEGFA and PDGFB decreased, resulting in RAOEC angiogenesis inhibition. Finally, the dual-luciferase reporter gene assay and chromatin immunoprecipitation (ChIP) assay proved that the HIF-1α/PDGFB pathway played a more critical role in tenocyte angiogenesis than the HIF-1α/VEGFA pathway. TSA could alleviate angiogenesis mainly through epigenetic regulation of the HIF-1α/PDGFB pathway. Taken together, TSA might be a promising anti-angiogenesis drug for abnormal angiogenesis, which is induced by tendon injuries.

Correspondence of the Effect of Shear Stress Magnitude on Endothelial Cell Alignment and Heparan Sulfate Expression

2010 ◽  
Author(s):  
Charles S. Wallace ◽  
Tobias Hasenberg ◽  
Morton H. Friedman
Keyword(s):  
Nitric Oxide ◽  
Heparan Sulfate ◽  
Cell Junctions ◽  
Endothelial Glycocalyx ◽  
Vascular Endothelial ◽  
Blood Components ◽  
Cell Alignment ◽  
Vascular Endothelial Cadherin ◽  
Endothelial Functions

The endothelial glycocalyx is believed to play a crucial role in many endothelial functions, including mechanotransduction [1,2], modulation of vascular permeability, and interaction with blood components [3]. A principal constituent of the glycocalyx, thought to sense shearing forces and convey this signal into the cell, is the glycosaminoglycan heparan sulfate (HS). Previous in vitro studies have shown that batch removal of 60% of the heparan sulfate within the glycocalyx inhibits the steady shear-induced production of nitric oxide [4], cell alignment, cell migration, suppression of cell proliferation, and accumulation of vascular endothelial cadherin in cell-cell junctions [5].

Improvement of Exercise Intervention on Vascular Endothelial Functions during Prediabetes Mellitus

2017 ◽  
Vol 16 (4) ◽  
Author(s):  
Shaobing Wang ◽  
Zhenghong Zhang ◽  
Yiping Liu ◽  
Zhengchao Wang
Keyword(s):  
Exercise Intervention ◽  
Vascular Endothelial ◽  
Endothelial Functions

scholarly journals An overview on far-infrared functional textile materials

2020 ◽  
Author(s):  
Ovidiu Iordache ◽  
Elena Cornelia Mitran ◽  
Irina Sandulache ◽  
Maria Memecica ◽  
Lucia Oana Secareanu ◽  
...  
Keyword(s):  
Health Effect ◽  
Negative Ions ◽  
Far Infrared ◽  
Vascular Endothelial ◽  
Textile Materials ◽  
Synthetic Fibers ◽  
Mechanical Parts ◽  
Positive Effects ◽  
Skin Cell ◽  
Endothelial Functions

The present study was aimed at highlighting the applicability of novel generations of functional textile materials based on incorporation of safe, pyroelectric nanoparticles into fibers. The synthetic fibers with negative ions emitting properties contain semiprecious stone particles (tourmaline, monazite, opal), ceramic, charcoal, zirconium powders, aluminum titanate and mixtures of such minerals. Currently, the synthetic fibers generating pyroelectric effects are obtained by introducing minerals (e.g. superfine tourmaline powder) into melted polymers before spinning or by dispersing the minerals into the spinning solution. As polymers, polyethylene terephthalate, polyvinyl acetate, polyamide and viscose have been used. In low quantities, these minerals have almost no effect on human health. Included in large quantities, they tend to be too expensive (tourmaline, opal) and the fibers become harsh and fragile. The current generation of FIR functional textile materials faces a series of technical challenges: some of the of the used compounds are radioactive (monazite); if the particles size is too large (0.2-0.3µm), it may result in the production of highly non-uniform fibers and early wear of the mechanical parts producing installation; most of commercial pyroelectric fabrics emit a low amount of negative ions (500-2600 anions/cc) and FI rays, inducing a low health effect. Clinical studies involving exposure to pyroelectric compounds have highlighted positive effects on: blood circulation, skin cell re-vitalizing, collagen and elastin production, sleep modulation, wounds healing and acceleration of micro-circulation, chronic pain management, improvement of vascular endothelial functions, atherosclerosis and arthritis affections etc.

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