The Dynamic Nature of Vascular Endothelial Functions

2015 ◽  
pp. 80-99 ◽  
Author(s):  
Peter Libby ◽  
Louis K. Birinyi
Keyword(s):  
Vascular Endothelial ◽  
Dynamic Nature ◽  
Endothelial Functions

scholarly journals P66Shc and vascular endothelial function

2019 ◽  
Vol 39 (4) ◽  
Author(s):  
Santosh Kumar
Keyword(s):  
Endothelial Function ◽  
Vascular Endothelium ◽  
Physiological Function ◽  
Vascular Endothelial ◽  
Molecular Signaling ◽  
Vascular Endothelial Function ◽  
Pathological Conditions ◽  
Endothelial Functions ◽  
Active Research ◽  
Oxidative Function

Abstract Dysfunctional endothelium is an early change in vasculature known to be associated with atherosclerosis. Among many regulators of vascular endothelial function, p66Shc has consistently been shown to mediate endothelial dysfunction. Over more than three decades of active research in the field of the physiological function of p66Shc, regulation of vascular endothelial functions has emerged as one of the most robust effects in a broad range of pathological conditions including hyperlipidemia, diabetes, and aging. A significant understanding has been developed with respect to the molecular signaling regulating the oxidative function of p66Shc in endothelial cells and its targets and regulators. In addition, novel regulatory modifications of p66Shc controlling its oxidative function, subcellular distribution, and stability have also been reported. This review will focus on summarizing the molecular signaling regulating the oxidative function of p66Shc and its role in vascular endothelium.

Correspondence of the Effect of Shear Stress Magnitude on Endothelial Cell Alignment and Heparan Sulfate Expression

2010 ◽  
Author(s):  
Charles S. Wallace ◽  
Tobias Hasenberg ◽  
Morton H. Friedman
Keyword(s):  
Nitric Oxide ◽  
Heparan Sulfate ◽  
Cell Junctions ◽  
Endothelial Glycocalyx ◽  
Vascular Endothelial ◽  
Blood Components ◽  
Cell Alignment ◽  
Vascular Endothelial Cadherin ◽  
Endothelial Functions

The endothelial glycocalyx is believed to play a crucial role in many endothelial functions, including mechanotransduction [1,2], modulation of vascular permeability, and interaction with blood components [3]. A principal constituent of the glycocalyx, thought to sense shearing forces and convey this signal into the cell, is the glycosaminoglycan heparan sulfate (HS). Previous in vitro studies have shown that batch removal of 60% of the heparan sulfate within the glycocalyx inhibits the steady shear-induced production of nitric oxide [4], cell alignment, cell migration, suppression of cell proliferation, and accumulation of vascular endothelial cadherin in cell-cell junctions [5].

Improvement of Exercise Intervention on Vascular Endothelial Functions during Prediabetes Mellitus

2017 ◽  
Vol 16 (4) ◽  
Author(s):  
Shaobing Wang ◽  
Zhenghong Zhang ◽  
Yiping Liu ◽  
Zhengchao Wang
Keyword(s):  
Exercise Intervention ◽  
Vascular Endothelial ◽  
Endothelial Functions

scholarly journals An overview on far-infrared functional textile materials

2020 ◽  
Author(s):  
Ovidiu Iordache ◽  
Elena Cornelia Mitran ◽  
Irina Sandulache ◽  
Maria Memecica ◽  
Lucia Oana Secareanu ◽  
...  
Keyword(s):  
Health Effect ◽  
Negative Ions ◽  
Far Infrared ◽  
Vascular Endothelial ◽  
Textile Materials ◽  
Synthetic Fibers ◽  
Mechanical Parts ◽  
Positive Effects ◽  
Skin Cell ◽  
Endothelial Functions

The present study was aimed at highlighting the applicability of novel generations of functional textile materials based on incorporation of safe, pyroelectric nanoparticles into fibers. The synthetic fibers with negative ions emitting properties contain semiprecious stone particles (tourmaline, monazite, opal), ceramic, charcoal, zirconium powders, aluminum titanate and mixtures of such minerals. Currently, the synthetic fibers generating pyroelectric effects are obtained by introducing minerals (e.g. superfine tourmaline powder) into melted polymers before spinning or by dispersing the minerals into the spinning solution. As polymers, polyethylene terephthalate, polyvinyl acetate, polyamide and viscose have been used. In low quantities, these minerals have almost no effect on human health. Included in large quantities, they tend to be too expensive (tourmaline, opal) and the fibers become harsh and fragile. The current generation of FIR functional textile materials faces a series of technical challenges: some of the of the used compounds are radioactive (monazite); if the particles size is too large (0.2-0.3µm), it may result in the production of highly non-uniform fibers and early wear of the mechanical parts producing installation; most of commercial pyroelectric fabrics emit a low amount of negative ions (500-2600 anions/cc) and FI rays, inducing a low health effect. Clinical studies involving exposure to pyroelectric compounds have highlighted positive effects on: blood circulation, skin cell re-vitalizing, collagen and elastin production, sleep modulation, wounds healing and acceleration of micro-circulation, chronic pain management, improvement of vascular endothelial functions, atherosclerosis and arthritis affections etc.

Elevated circulating endothelial-specific microRNAs in migraine patients: A pilot study

Cephalalgia ◽  
2017 ◽  
Vol 38 (9) ◽  
pp. 1585-1591 ◽  
Author(s):  
Chun-Yu Cheng ◽  
Shih-Pin Chen ◽  
Yi-Chu Liao ◽  
Jong-Ling Fuh ◽  
Yen-Feng Wang ◽  
...  
Keyword(s):  
Pilot Study ◽  
Endothelial Function ◽  
Exploratory Study ◽  
Vascular Dysfunction ◽  
Control Group ◽  
Vascular Endothelial ◽  
Vascular Risk ◽  
The Past ◽  
Endothelial Functions ◽  
Circulating Levels

Background Evidence of vascular dysfunction in migraine is increasing. MicroRNAs (miRs) have emerged as important regulators of vascular endothelial functions. This exploratory study investigated whether circulating levels of miRs associated with endothelial function are altered in migraine patients. Methods Thirty patients with migraine (20–50 years old) without overt vascular risk factors and 30 sex- and age-matched healthy controls participated. The levels of four miRs that regulate endothelial function (miR-155, miR-126, miR-21, and Let-7g) were quantified and expressed in terms of fold changes (2−ΔΔct) relative to mean levels in the control group. Associations of miRs levels with headache features and syncope comorbidity were explored. Results Compared to controls, migraine patients had upregulated expression of miR-155 (6.17-fold, p = 0.018), miR-126 (6.17-fold, p = 0.013), and let-7g (7.37-fold, p = 0.005). Levels of miR-155 (r = 0.375, p = 0.041) and miR-126 (r = 0.375, p = 0.041) were associated with syncope frequency in the past year in migraine patients. Migraine patients with aura have insignificant higher expression of miRs levels compared to those without. Conclusions In this pilot study, circulating levels of endothelial-specific miRs appear to be elevated in migraine patients and may be associated with syncope comorbidity.

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