Squamous cell carcinoma antigen, platelet distribution width, and prealbumin collectively as a marker of squamous cell cervical carcinoma

2018 ◽  
Vol 21 (2) ◽  
pp. 317-321 ◽  
Author(s):  
Shuang Fu ◽  
Ye Niu ◽  
Xin Zhang ◽  
Ji-Rong Zhang ◽  
Zhi-Ping Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cervical Carcinoma ◽  
Squamous Cell ◽  
Platelet Distribution Width ◽  
Squamous Cell Carcinoma Antigen ◽  
Distribution Width ◽  
Squamous Cell Cervical Carcinoma

Prognostic Value of Squamous Cell Carcinoma Antigen in Patients with Uterine Cervical Carcinoma

1988 ◽  
Vol 74 (2) ◽  
pp. 221-225 ◽  
Author(s):  
Jyotsna M. Bhatavdekar ◽  
Nandita Ghosh ◽  
Minakshi K. Shukla ◽  
Damodar B. Balar ◽  
Anita Bhaduri ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cervical Carcinoma ◽  
Squamous Cell ◽  
Large Cell ◽  
Diagnostic Value ◽  
Squamous Cell Carcinoma Antigen ◽  
Histologic Subtype ◽  
Uterine Cervical Carcinoma ◽  
Highly Correlated

Squamous cell carcinoma antigen (SCC Ag) was estimated in 30 controls, in 16 patients with benign lesions of the uterine cervix, and in 51 patients with uterine cervical carcinoma. The rate of positivity of the antigen among the cancer patients was 87% (N = 49). SCC Ag estimations were of no diagnostic value, since 37% of patients with bening lesions had elevated levels compared to controls. SCC Ag was highly correlated to histologic subtype. The highest values were obtained in keratinizing tumors, followed by large cell nonkeratinizing and small cell nonkeratinizing types. Moreover, elevation of SCC Ag was statistically significant (p < 0.001) among all the three histologic subtypes compared to controls. However, SCC Ag levels were not consistently correlated to the stage of the disease. Patients with pretherapeutic SCC Ag levels above 30 ng/ml had a faster recurrence rate and shorter survival than those who exhibited antigen values below 2.0 ng/ml. From our results, it is suggested that SCC Ag has limited use as a parameter for early diagnosis of cervical carcinoma, but it seems to reflect advancement of the disease. These findings indicate that SCC Ag elevation may prove to be a valuable marker in predicting subclinical disease.

scholarly journals Elevated preoperative platelet distribution width predicts poor prognosis in Esophageal Squamous Cell Carcinoma

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Qian Song ◽  
Jun-zhou Wu ◽  
Sheng Wang ◽  
Wen-hu Chen
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Esophageal Squamous Cell Carcinoma ◽  
Confidence Interval ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Disease Free Survival ◽  
Platelet Distribution Width ◽  
Distribution Width ◽  
Hazard Ratios

Abstract Activated platelets play a multifaceted role in tumorigenesis and progression. Platelet distribution width (PDW) is generally applied platelet parameters from routine blood test. Preoperative PDW has been considered a prognostic factor in many cancers. Nevertheless, the prognostic value of PDW in esophageal squamous cell carcinoma (ESCC) remains unknown. The study aimed to investigate whether preoperative PDW could serve as a prognostic factor in patients with ESCC. A total of 495 patients with ESCC undergoing curative surgery were enrolled. The relationship between PDW and clinical features in ESCC was analyzed using chi-square tests. Receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value. Overall survival (OS) and disease-free survival (DFS) stratified by PDW were evaluated by Kaplan–Meier method and log-rank test. Univariate and multivariate Cox regression were used to evaluate the prognostic effect of PDW. Of the 495 patients, elevated PDW was observed in 241(48.7%) of the patients, respectively. An elevated PDW was correlated with depth of tumor (T stage, P = 0.031), nerve infiltration (P = 0.016), hospital time after operation (P = 0.020), platelet (P < 0.001), red cell distribution width (P < 0.001), and aspartate transaminase (P = 0.001). Moreover, elevated PDW (PDW ≥ 13.4 fL) predicted a worse OS and DFS in patients with ESCC (both P < 0.001). Multivariate analyses revealed that PDW was independently associated with OS (hazard ratios 1.194; 95% confidence interval 1.120–1.273; P < 0.001) and DFS (hazard ratios 2.562; 95% confidence interval 1.733–3.786; P < 0.001). Our findings indicated that elevated PDW could serve as an independent worse survival in ESCC.

Value of squamous cell carcinoma antigen levels in invasive cervical carcinoma

1989 ◽  
Vol 34 (3) ◽  
pp. 312-316 ◽  
Author(s):  
Mitchell Maiman ◽  
Gerald Feuer ◽  
Rachel G. Fruchter ◽  
Norman Shaw ◽  
John Boyce
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cervical Carcinoma ◽  
Squamous Cell ◽  
Squamous Cell Carcinoma Antigen ◽  
Invasive Cervical Carcinoma

scholarly journals Invasive Squamous Cell Carcinoma of the Cervix in Pregnancy: A Case Report

2020 ◽  
pp. 30-34
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cervical Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Cervical Squamous Cell Carcinoma ◽  
Disease Stage ◽  
Invasive Squamous Cell Carcinoma ◽  
Squamous Cell Cervical Carcinoma ◽  
Common Histological Type

Cervical squamous cell carcinoma is the most common histological type of carcinoma in the uterine cervix, but during pregnancy is relativity uncommon, with an incidence of 0.8 to 1.5 cases per 10,000 births. Cervical squamous cell carcinoma is the leading cause of death among women aged 35 to 54 years and the second most common cause among women aged 15 to 34 years after breast carcinoma. Most patients are diagnosed at an early stage of the disease, probably due to routine prenatal screening. The occurrence of invasive cervical carcinoma is relatively uncommon in pregnant women. However, cancer treatment during pregnancy currently remains one of the main and biggest therapeutic challenges in cervical cancer. The therapeutic approach should be customized and depends mainly on histology, disease stage, and gestational age. We present a case concerning a 26-year-old woman with invasive moderately differentiated keratinizing squamous cell cervical carcinoma, stage pT2b, N1, M0/ FIGOIIB, during pregnancy (4th lunar month).

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