Transient Increase in Squamous Cell Carcinoma Antigen Expression in Cultured Cervical Carcinoma CaSki Cells in Response to Exposure to cis-Diamminedichloroplatinum

Tumor Biology ◽  
2003 ◽  
Vol 24 (5) ◽  
pp. 219-227
Author(s):  
Y. Tateiwa ◽  
S. Yoshida ◽  
Y. Miyahara ◽  
S. Hamana ◽  
S. Motoyama ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cervical Carcinoma ◽  
Squamous Cell ◽  
Antigen Expression ◽  
Transient Increase ◽  
Squamous Cell Carcinoma Antigen

Prognostic Value of Squamous Cell Carcinoma Antigen in Patients with Uterine Cervical Carcinoma

1988 ◽  
Vol 74 (2) ◽  
pp. 221-225 ◽  
Author(s):  
Jyotsna M. Bhatavdekar ◽  
Nandita Ghosh ◽  
Minakshi K. Shukla ◽  
Damodar B. Balar ◽  
Anita Bhaduri ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cervical Carcinoma ◽  
Squamous Cell ◽  
Large Cell ◽  
Diagnostic Value ◽  
Squamous Cell Carcinoma Antigen ◽  
Histologic Subtype ◽  
Uterine Cervical Carcinoma ◽  
Highly Correlated

Squamous cell carcinoma antigen (SCC Ag) was estimated in 30 controls, in 16 patients with benign lesions of the uterine cervix, and in 51 patients with uterine cervical carcinoma. The rate of positivity of the antigen among the cancer patients was 87% (N = 49). SCC Ag estimations were of no diagnostic value, since 37% of patients with bening lesions had elevated levels compared to controls. SCC Ag was highly correlated to histologic subtype. The highest values were obtained in keratinizing tumors, followed by large cell nonkeratinizing and small cell nonkeratinizing types. Moreover, elevation of SCC Ag was statistically significant (p < 0.001) among all the three histologic subtypes compared to controls. However, SCC Ag levels were not consistently correlated to the stage of the disease. Patients with pretherapeutic SCC Ag levels above 30 ng/ml had a faster recurrence rate and shorter survival than those who exhibited antigen values below 2.0 ng/ml. From our results, it is suggested that SCC Ag has limited use as a parameter for early diagnosis of cervical carcinoma, but it seems to reflect advancement of the disease. These findings indicate that SCC Ag elevation may prove to be a valuable marker in predicting subclinical disease.

Value of squamous cell carcinoma antigen levels in invasive cervical carcinoma

1989 ◽  
Vol 34 (3) ◽  
pp. 312-316 ◽  
Author(s):  
Mitchell Maiman ◽  
Gerald Feuer ◽  
Rachel G. Fruchter ◽  
Norman Shaw ◽  
John Boyce
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cervical Carcinoma ◽  
Squamous Cell ◽  
Squamous Cell Carcinoma Antigen ◽  
Invasive Cervical Carcinoma
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