MicroRNAs in esophageal squamous cell carcinoma: Potential biomarkers and therapeutic targets

2017 ◽  
Vol 19 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Li-Li Mei ◽  
Yun-Tan Qiu ◽  
Bing Zhang ◽  
Zhi-Zhou Shi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Therapeutic Targets ◽  
Potential Biomarkers

scholarly journals Potential Role of Targeting KDR and Proteasome Inhibitors in the Therapy of Esophageal Squamous Cell Carcinoma

2020 ◽  
Vol 19 ◽  
pp. 153303382094806
Author(s):  
Ling Zhang ◽  
Xia Niu ◽  
Yanghui Bi ◽  
Heyang Cui ◽  
Hongyi Li ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Zinc Finger Protein ◽  
Cancer Genomics ◽  
Therapeutic Targets ◽  
Specific Inhibitor ◽  
Genomic Variation ◽  
Tumor Xenograft

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancer types in China. In recent years, progress has been made in various types of cancer genomics including ESCC. However, the clinical significance of genomic variation of ESCC remains poorly defined. In the present study, genomic sequencing data from 469 ESCC cases were analyzed and potential therapeutic targets in the Druggable Genome Interaction Database (DGIdb) were screened. A series of potential therapeutic target genes and pathways were identified, of which treatment of ESCC with bortezomib (a specific inhibitor targeting proteasome) potently inhibited the proliferation of 5 ESCC cell lines and administration of bortezomib led to significant tumor xenograft regression in SCID mice. It was also identified that kinase insert domain receptor (KDR), which had drug recommendations from all 6 sources integrated by the DGldb and harbored significant amplification in ESCC, might be a downstream target of zinc finger protein 750 (ZNF750). ZNF750 acts as a transcription factor and has been demonstrated to harbor frequently inactivating mutations in ESCC by previous independent studies. In the present study, KDR was upregulated upon ZNF750 knockdown and the rescue of ZNF750 also led to marked restoration of KDR. KDR knockdown in stable ZNF750-knockdown KYSE150 and KYSE140 ESCC cells significantly attenuated the promotion of cell growth, colony formation, invasion and migration induced by ZNF750 knockdown. Further experiments found that apatinib treatment, a potent inhibitor of KDR, resulted in profound inhibition of cell proliferation and invasion. Collectively, the present study provided insight for genomic alterations as potential therapeutic targets in ESCC and supported the possibility of a therapeutic strategy targeting the proteasome in ESCC. The present results also suggested that targeting KDR may be an effective way to treat ESCC, not only in KDR variant cases, but also in individuals with ZNF750 mutations and deletions.

New potential biomarkers in the diagnosis of esophageal squamous cell carcinoma

Biomarkers ◽  
2009 ◽  
Vol 14 (5) ◽  
pp. 340-346 ◽  
Author(s):  
Shu-Yong Xu ◽  
Zan Liu ◽  
Wen-Jing Ma ◽  
Ilyar Sheyhidin ◽  
Shu-Tao Zheng ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Potential Biomarkers
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