Complexin-2 (CPLX2) as a potential prognostic biomarker in human lung high grade neuroendocrine tumors

2013 ◽  
Vol 13 (3) ◽  
pp. 171-180 ◽  
Author(s):  
Hiroaki Komatsu ◽  
Anna Kakehashi ◽  
Noritoshi Nishiyama ◽  
Nobuhiro Izumi ◽  
Shinjiro Mizuguchi ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Human Lung ◽  
Prognostic Biomarker ◽  
High Grade ◽  
Complexin 2

scholarly journals Emerging Therapeutic Concepts and Latest Diagnostic Advancements Regarding Neuroendocrine Tumors of the Gynecologic Tract

Medicina ◽  
2021 ◽  
Vol 57 (12) ◽  
pp. 1338
Author(s):  
Tiberiu-Augustin Georgescu ◽  
Roxana Elena Bohiltea ◽  
Octavian Munteanu ◽  
Florentina Furtunescu ◽  
Antonia-Carmen Lisievici ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Neuroendocrine Carcinoma ◽  
Classification System ◽  
Who Classification ◽  
Small Cell ◽  
International Agency ◽  
Low Grade ◽  
High Grade ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Female Genital

Neuroendocrine neoplasms (NENs) are particularly rare in all sites of the gynecological tract and include a variety of neoplasms with variable prognosis, dependent on histologic subtype and site of origin. Following the expert consensus proposal of the International Agency for Research on Cancer (IARC), the approach in the latest World Health Organization (WHO) Classification System of the Female Genital Tumours is to use the same terminology for NENs at all body sites. The main concept of this novel classification framework is to align it to all other body sites and make a clear distinction between well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). The previous WHO Classification System of the Female Genital Tumours featured more or less the same principle, but used the terms ‘low-grade neuroendocrine tumor’ and ‘high-grade neuroendocrine carcinoma’. Regardless of the terminology used, each of these two main categories include two distinct morphological subtypes: NETs are represented by typical and atypical carcinoid and NEC are represented by small cell neuroendocrine carcinoma (SCNEC) and large cell neuroendocrine carcinoma (LCNEC). High-grade NECs, especially small cell neuroendocrine carcinoma tends to be more frequent in the uterine cervix, followed by the endometrium, while low-grade NETs usually occur in the ovary. NENs of the vulva, vagina and fallopian tube are exceptionally rare, with scattered case reports in the scientific literature.

scholarly journals TCR Clonality and Genomic Instability Signatures as Prognostic Biomarkers in High Grade Serous Ovarian Cancer

Cancers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 4394
Author(s):  
Julie Lecuelle ◽  
Romain Boidot ◽  
Hugo Mananet ◽  
Valentin Derangère ◽  
Juliette Albuisson ◽  
...  
Keyword(s):  
T Cell ◽  
Genomic Instability ◽  
Survival Data ◽  
Prognostic Value ◽  
Prognostic Biomarker ◽  
Copy Number Variant ◽  
Cell Receptor ◽  
The Cancer Genome Atlas ◽  
High Grade ◽  
Cell Infiltrate

Purpose: Immune infiltration is a prognostic factor in high-grade serous ovarian carcinoma (HGSC) but immunotherapy efficacy is disappointing. Genomic instability is now used to guide the therapeutic value of PARP inhibitors. We aimed to investigate exome-derived parameters to assess the tumor microenvironment according to genomic instability profile. Methods: We used the HGSC TCGA (the cancer genome atlas) dataset with genomic characteristics, including homologous recombination deficiency (HRD), copy number variant (CNV) signatures, TCR (T cell receptor) clonality and abundance of tissue-infiltrating immune and stromal cell populations. We then investigated the relationship with survival data. Results: In 578 HGSC patients, HRD status, CNV signature 7 and TCR clonality were associated with longer survival. The combination of high CNV signature 7 expression and HRD status or high CNV signature 3 expression and high TCR clonality was associated with a trend towards longer survival compared to each variable alone. Combining T cell infiltrate and TCR clonality improved the prognostic value compared to T cells infiltration alone. Prognostic value of TCR clonality was confirmed in an independent cohort. Conclusions: TCR clonality is an emerging prognostic biomarker that improves T cell infiltrate information. Analysis of TCR clonality combined with genomic instability could be an interesting prognostic biomarker.

scholarly journals P1.12-05 Efficacy of Perioperative Chemotherapy for High-Grade Neuroendocrine Tumors

2018 ◽  
Vol 13 (10) ◽  
pp. S574-S575
Author(s):  
H. Ogawa ◽  
Y. Tanaka ◽  
Y. Kitamura ◽  
H. Tanaka ◽  
Y. Nishioka ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
High Grade ◽  
Perioperative Chemotherapy

scholarly journals Stathmin-1 Is a Useful Diagnostic Marker for High-Grade Lung Neuroendocrine Tumors

2019 ◽  
Vol 108 (1) ◽  
pp. 235-243
Author(s):  
Kimihiro Shimizu ◽  
Yusuke Goto ◽  
Reika Kawabata-Iwakawa ◽  
Yoichi Ohtaki ◽  
Seshiru Nakazawa ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Diagnostic Marker ◽  
High Grade ◽  
Stathmin 1

scholarly journals Amphicrine carcinoma of the stomach and intestine: a clinicopathologic and pan-cancer transcriptome analysis of a distinct entity

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Dan Huang ◽  
Fei Ren ◽  
Shujuan Ni ◽  
Cong Tan ◽  
Weiwei Weng ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Expression Patterns ◽  
Biological Behavior ◽  
Low Grade ◽  
High Grade ◽  
Clinicopathologic Characteristics ◽  
Signet Ring ◽  
Cancer Transcriptome ◽  
Male Patients ◽  
Pan Cancer

Abstract Background and aim Amphicrine carcinoma, in which endocrine and epithelial cell constituents are present within the same cell, is very rare. This study characterized the clinicopathologic and survival analysis of this tumor, further compared the genetic diversities among amphicrine carcinoma and other tumors. Materials and methods The clinicopathologic characteristics and survival outcomes of amphicrine carcinoma in this study were analyzed. The pan-cancer transcriptome assay was utilized to compare the genetic expression profile of this entity with that of conventional adenocarcinoma or neuroendocrine tumors. Results Ten cases (all in male patients) were identified in the stomach or intestine, with a median patient age of 62 years. There were characteristic patterns in the tumors: tubular, fusion or single-file growth of goblet- or signet ring-like cells. Four tumors were classified as low-grade and 6 as high-grade according to the histologic architecture. All cases were positive for neuroendocrine markers (synaptophysin and chromogranin A) and showed intracellular mucin in the amphicrine components. Four cases exhibited mRNA expression patterns showing transcriptional homogeneity with conventional adenocarcinomas and genetic diversity from neuroendocrine tumors. During the follow-up period, 3 patients died of disease, all of whom had high-grade tumors. Patients with high-grade amphicrine carcinoma had worse outcomes than those with low-grade tumors. Conclusions This study confirms the morphological, immunostaining and transcriptome alterations in amphicrine carcinoma distinct from those in conventional adenocarcinomas and neuroendocrine tumors, but additional studies are warranted to determine the biological behavior and therapeutic response.

Ga-68 DOTATATE PET/CT and F-18 FDG PET/CT in the evaluation of low and intermediate versus high-grade neuroendocrine tumors

2020 ◽  
Vol 41 (10) ◽  
pp. 1060-1065
Author(s):  
Helena You ◽  
Asha Kandathil ◽  
Muhammad Beg ◽  
Lorraine De Blanche ◽  
Syed Kazmi ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Fdg Pet ◽  
High Grade ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals Long noncoding RNA LINC00152 is a potential prognostic biomarker in patients with high-grade glioma

2018 ◽  
Vol 24 (10) ◽  
pp. 957-966 ◽  
Author(s):  
Wen Wang ◽  
Fan Wu ◽  
Zheng Zhao ◽  
Kuan-Yu Wang ◽  
Ruo-Yu Huang ◽  
...  
Keyword(s):  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Prognostic Biomarker ◽  
High Grade Glioma ◽  
High Grade
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