Raman spectroscopy applications for the diagnosis and follow-up of type 2 diabetes mellitus. A brief review

2020 ◽  
Vol 9 (3-4) ◽  
pp. 119-140
Author(s):  
Alejandra Loyola-Leyva ◽  
Karen Hernández-Vidales ◽  
Juan Pablo Loyola-Rodríguez ◽  
Francisco Javier González
Keyword(s):  
Type 2 Diabetes ◽  
Raman Spectroscopy ◽  
Low Cost ◽  
Surface Enhanced Raman Spectroscopy ◽  
Optical Techniques ◽  
Non Invasive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Background: There is considerable interest in developing faster, less invasive, and more objective techniques to diagnose type 2 diabetes mellits (T2DM). Optical techniques like Raman spectroscopy and surface-enhanced Raman spectroscopy (SERS) are efficient, precise, low-cost, portable, and easy to handle, which seem to overcome most of the present difficulties of actual tests for T2DM diagnosis. However, the use of both Raman spectroscopy and surface-enhanced Raman spectroscopy (SERS) has been limited for T2DM diagnosis or follow-up. Objective: To gather information regarding the use of Raman spectroscopy and SERS to evaluate the spectra of biofluids (blood components, saliva, and urine) and tissues (skin) as an early diagnostic tool or follow-up for T2DM. Results: Skin and biofluids provide a great amount of information that can be analyzed by Raman spectroscopy and SERS. These optical techniques are excellent for clinical applications and can differentiate people with T2DM from healthy individuals, predict complications arising from T2DM (chronic kidney disease), and might be used to monitor glucose (glycemic control). Conclusion: Raman spectroscopy and SERS are good optical techniques for the diagnosis of T2DM in which sample preparation is not necessary or very simple, non-destructive, non-invasive, relatively fast to acquire, and low-cost.

scholarly journals Bimetallic Core–Shell Nanoparticles of Gold and Silver via Bioinspired Polydopamine Layer as Surface-Enhanced Raman Spectroscopy (SERS) Platform

Nanomaterials ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 688 ◽  
Author(s):  
Asli Yilmaz ◽  
Mehmet Yilmaz
Keyword(s):  
Raman Spectroscopy ◽  
Low Cost ◽  
Silver Ions ◽  
Surface Enhanced Raman Spectroscopy ◽  
Core Shell ◽  
Silver Deposition ◽  
Shell Nanoparticles ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Core Shell Nanoparticles

Despite numerous attempts to fabricate the core–shell nanoparticles, novel, simple, and low-cost approaches are still required to produce these efficient nanosystems. In this study, we propose the synthesis of bimetallic core–shell nanoparticles of gold (AuNP) and silver (AgNP) nanostructures via a bioinspired polydopamine (PDOP) layer and their employment as a surface-enhanced Raman spectroscopy (SERS) platform. Herein, the PDOP layer was used as an interface between nanostructures as well as stabilizing and reducing agents for the deposition of silver ions onto the AuNPs. UV-vis absorption spectra and electron microscope images confirmed the deposition of the silver ions and the formation of core–shell nanoparticles. SERS activity tests indicated that both the PDOP thickness and silver deposition time are the dominant parameters that determine the SERS performances of the proposed core–shell system. In comparison to bare AuNPs, more than three times higher SERS signal intensity was obtained with an enhancement factor of 3.5 × 105.

Physically Self-assembled Au Nanorod Arrays for SERS

2006 ◽  
Vol 951 ◽  
Author(s):  
Motofumi Suzuki ◽  
Kaoru Nakajima ◽  
Kenji Kimura ◽  
Takao Fukuoka ◽  
Yasushige Mori
Keyword(s):  
Raman Spectroscopy ◽  
Low Cost ◽  
Major Axis ◽  
Surface Enhanced Raman Spectroscopy ◽  
Nanorod Arrays ◽  
Au Nanorods ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Oblique Deposition ◽  
Selection Of

ABSTRACTWe have demonstrated surface-enhanced Raman spectroscopy on arrays of Au nanorods aligned in line by a dynamic oblique deposition technique. For the light polarized along the major axis of the nanorods, the plasma resonance of the Au nanorods has been tuned to a wavelength suitable for Raman spectroscopy. The Raman scattering on the discrete nanorods is enhanced significantly compared with that on semi continuous Au films. Since the preparation process is physically bottom-up, it is robust in its selection of the materials and is useful in providing the SERS sensors at low cost.

scholarly journals A simple and reliable approach for the fabrication of nanoporous silver patterns for surface-enhanced Raman spectroscopy applications

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Angela Capaccio ◽  
Antonio Sasso ◽  
Giulia Rusciano
Keyword(s):  
Raman Spectroscopy ◽  
Inductively Coupled Plasma ◽  
Low Cost ◽  
Cost Effective ◽  
Surface Enhanced Raman Spectroscopy ◽  
Raman Signal ◽  
Plasmonic Nanostructures ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Good Signal

AbstractThe fabrication of plasmonic nanostructures with a reliable, low cost and easy approach has become a crucial and urgent challenge in many fields, including surface-enhanced Raman spectroscopy (SERS) based applications. In this frame, nanoporous metal films are quite attractive, due to their intrinsic large surface area and high density of metal nanogaps, acting as hot-spots for Raman signal enhancement. In this paper, we report a detailed study on the fabrication of nanoporous silver-based SERS substrates, obtained by the application of two successive treatments with an Inductively Coupled Plasma (ICP) system, using synthetic air and Ar as feeding gases. The obtained substrates exhibit a quite broad plasmonic response, covering the Vis–NIR range, and an enhancement factor reaching 6.5 $$\times\, 10^7$$ × 10 7 , estimated by using 4-mercaptobenzoic acid (4-MBA) as probe molecule at 532 nm. Moreover, the substrates exhibit a quite good spatial reproducibility on a centimeter scale, which assures a good signal stability for analytical measurements. Globally, the developed protocol is easy and cost effective, potentially usable also for mass production thanks to the remarkable inter-batches reproducibility. As such, it holds promise for its use in SERS-based sensing platforms for sensitive detection of targets molecules.

Non-invasive diagnosis of Crohn's disease based on SERS combined with PCA-SVM

2021 ◽  
Author(s):  
Bingyan Li ◽  
Yaling Wu ◽  
Zijie Wang ◽  
Mengmeng Xing ◽  
Weimin Xu ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Surface Enhanced Raman Spectroscopy ◽  
Metabolic Change ◽  
Healthy Controls ◽  
Non Invasive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

The metabolic change of patients (Crohn's disease (CD)/active CD (aCD)/inactive CD (iCD)) and healthy controls (HC) could be identified by measuring urine with surface-enhanced Raman spectroscopy (SERS).

ZnO–Ag hybrids for ultrasensitive detection of trinitrotoluene by surface-enhanced Raman spectroscopy

2014 ◽  
Vol 16 (28) ◽  
pp. 14706-14712 ◽  
Author(s):  
Xuan He ◽  
Hui Wang ◽  
Zhongbo Li ◽  
Dong Chen ◽  
Qi Zhang
Keyword(s):  
Raman Spectroscopy ◽  
Low Cost ◽  
High Sensitivity ◽  
Surface Enhanced Raman Spectroscopy ◽  
Ultrasensitive Detection ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Hybrid Substrates ◽  
Tnt Detection

Low-cost SERS sensors were fabricated by 4-ATP-functionalized ZnO–Ag hybrid substrates for TNT detection with high sensitivity, selectivity and reproducibility.

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