scholarly journals Past, Present, and Possible Future Human Infection with Influenza Virus A Subtype H7

2009 ◽  
Vol 15 (6) ◽  
pp. 859-865 ◽  
Author(s):  
Jessica A. Belser ◽  
Carolyn B. Bridges ◽  
Jacqueline M. Katz ◽  
Terrence M. Tumpey
Keyword(s):  
Influenza Virus ◽  
Human Infection ◽  
Influenza Virus A

scholarly journals Human Infection with Influenza Virus A(H10N8) from Live Poultry Markets, China, 2014

2014 ◽  
Vol 20 (12) ◽  
Author(s):  
Tao Zhang ◽  
Yuhai Bi ◽  
Huaiyu Tian ◽  
Xiaowen Li ◽  
Di Liu ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Human Infection ◽  
Influenza Virus A ◽  
Live Poultry ◽  
Live Poultry Markets

scholarly journals Increased Survival after Gemfibrozil Treatment of Severe Mouse Influenza

2007 ◽  
Vol 51 (8) ◽  
pp. 2965-2968 ◽  
Author(s):  
Alison Budd ◽  
Lisa Alleva ◽  
Mohammed Alsharifi ◽  
Aulikki Koskinen ◽  
Victoria Smythe ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Proinflammatory Cytokines ◽  
Human Infection ◽  
Lipid Lowering ◽  
Once Daily ◽  
Influenza Virus A ◽  
H5n1 Strain ◽  
Human Use ◽  
Virus Survival ◽  
Lowering Activity

ABSTRACT Gemfibrozil, an agent that inhibits production of proinflammatory cytokines in addition to its clinically useful lipid-lowering activity, increased survival in BALB/c mice that were already ill from infection by influenza virus A/Japan/305/57 (H2N2). Gemfibrozil was administered intraperitoneally once daily from days 4 to 10 after intranasal exposure to the virus. Survival increased from 26% in vehicle-treated mice (n = 50) to 52% in mice given gemfibrozil at 60 mg/kg/day (n = 46) (P = 0.0026). If this principle translates to patients, a drug already approved for human use, albeit by a different route for another purpose, might be adapted relatively fast for use against influenza, conceivably including human infection with a derivative of the avian H5N1 strain.

scholarly journals Corticosteroids for the treatment of human infection with influenza virus: a systematic review and meta-analysis

2015 ◽  
Vol 21 (10) ◽  
pp. 956-963 ◽  
Author(s):  
J.-W. Yang ◽  
L.-C. Fan ◽  
X.-Y. Miao ◽  
B. Mao ◽  
M.-H. Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Influenza Virus ◽  
Meta Analysis ◽  
Human Infection ◽  
Influenza Virus A

1-Acyl-3-cyclooctylguanidines

1980 ◽  
Vol 45 (5) ◽  
pp. 1595-1600 ◽  
Author(s):  
Jaroslav Sluka ◽  
František Šmejkal ◽  
Zdeněk Buděšínský
Keyword(s):  
Influenza Virus ◽  
Herpes Simplex ◽  
Methyl Esters ◽  
Antiviral Effect ◽  
Influenza Virus A

On recation of cyclooctylamine with the sulfate of S-methylisothiourea cyclooctylguanidine was formed which was acylated with the methyl esters of 5-halogeno- and 3,5-dihalogeno-2-alkoxybenzoic acids. The 1-acyl-3-cyclooctylguanidine I-XVII formed were tested for their antiviral effect against the influenza virus A/NWS, A-PR8 and A2 Singapore, and further against the viruses NDV, herpes 2, vaccinia and WEE. In the in vivo test against the influenza virus A2 Singapore and herpes simplex 1-(5-bromo-2-dodecyloxybenzoyl)-3-cyclooctylguanidine is more active and less toxic than cyclooctylamine and 1-cyclooctylguanidine.

scholarly journals Synthesis and Antiviral Evaluation of Nucleoside Analogues Bearing One Pyrimidine Moiety and Two D-Ribofuranosyl Residues

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3678
Author(s):  
Olga V. Andreeva ◽  
Bulat F. Garifullin ◽  
Vladimir V. Zarubaev ◽  
Alexander V. Slita ◽  
Iana L. Yesaulkova ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Antiviral Activity ◽  
Theoretical Calculations ◽  
Nucleoside Analogs ◽  
Coxsackievirus B3 ◽  
Nucleoside Analogues ◽  
Moderate Activity ◽  
Coat Proteins ◽  
Influenza Virus A ◽  
Ic50 Values

A series of 1,2,3-triazolyl nucleoside analogues in which 1,2,3-triazol-4-yl-β-d-ribofuranosyl fragments are attached via polymethylene linkers to both nitrogen atoms of the heterocycle moiety (uracil, 6-methyluracil, thymine, quinazoline-2,4-dione, alloxazine) or to the C-5 and N-3 atoms of the 6-methyluracil moiety was synthesized. All compounds synthesized were evaluated for antiviral activity against influenza virus A/PR/8/34/(H1N1) and coxsackievirus B3. Antiviral assays revealed three compounds, 2i, 5i, 11c, which showed moderate activity against influenza virus A H1N1 with IC50 values of 57.5 µM, 24.3 µM, and 29.2 µM, respectively. In the first two nucleoside analogues, 1,2,3-triazol-4-yl-β-d-ribofuranosyl fragments are attached via butylene linkers to N-1 and N-3 atoms of the heterocycle moiety (6-methyluracil and alloxazine, respectively). In nucleoside analogue 11c, two 1,2,3-triazol-4-yl-2′,3′,5′-tri-O-acetyl-β-d-ribofuranose fragments are attached via propylene linkers to the C-5 and N-3 atoms of the 6-methyluracil moiety. Almost all synthesized 1,2,3-triazolyl nucleoside analogues showed no antiviral activity against the coxsackie B3 virus. Two exceptions are 1,2,3-triazolyl nucleoside analogs 2f and 5f, in which 1,2,3-triazol-4-yl-2′,3′,5′-tri-O-acetyl-β-d-ribofuranose fragments are attached to the C-5 and N-3 atoms of the heterocycle moiety (6-methyluracil and alloxazine respectively). These compounds exhibited high antiviral potency against the coxsackie B3 virus with IC50 values of 12.4 and 11.3 µM, respectively, although both were inactive against influenza virus A H1N1. According to theoretical calculations, the antiviral activity of the 1,2,3-triazolyl nucleoside analogues 2i, 5i, and 11c against the H1N1 (A/PR/8/34) influenza virus can be explained by their influence on the functioning of the polymerase acidic protein (PA) of RNA-dependent RNA polymerase (RdRp). As to the antiviral activity of nucleoside analogs 2f and 5f against coxsackievirus B3, it can be explained by their interaction with the coat proteins VP1 and VP2.

scholarly journals hFUT1-Based Live-Cell Assay To Profile α1-2-Fucoside-Enhanced Influenza Virus A Infection

2020 ◽  
Vol 15 (4) ◽  
pp. 819-823 ◽  
Author(s):  
Senlian Hong ◽  
Geramie Grande ◽  
Chenhua Yu ◽  
Digantkumar G. Chapla ◽  
Natalie Reigh ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Live Cell ◽  
Influenza Virus A ◽  
Cell Assay
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