Dregea volubilisAmeliorates Concanavalin A-Induced Liver Injury by Facilitating Apoptosis of Activated T Cells

2008 ◽  
Vol 233 (9) ◽  
pp. 1124-1132 ◽  
Author(s):  
Fangyuan Gong ◽  
Yan Shen ◽  
Chaofeng Zhang ◽  
Jianliang Xu ◽  
Xuefeng Wu ◽  
...  
Keyword(s):  
T Cells ◽  
Liver Injury ◽  
Concanavalin A ◽  
Activated T Cells

scholarly journals IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice

Hepatology ◽  
2007 ◽  
Vol 45 (2) ◽  
pp. 475-485 ◽  
Author(s):  
Annette Erhardt ◽  
Markus Biburger ◽  
Thomas Papadopoulos ◽  
Gisa Tiegs
Keyword(s):  
T Cells ◽  
Liver Injury ◽  
Regulatory T Cells ◽  
Kupffer Cells ◽  
Concanavalin A

scholarly journals Involvement of Up-Regulated CXC Chemokine Ligand 16/Scavenger Receptor That Binds Phosphatidylserine and Oxidized Lipoprotein in Endotoxin-Induced Lethal Liver Injury via Regulation of T-Cell Recruitment and Adhesion

2005 ◽  
Vol 73 (7) ◽  
pp. 4007-4016 ◽  
Author(s):  
Huanbin Xu ◽  
Wei Xu ◽  
Yiwei Chu ◽  
Yanping Gong ◽  
Zhenggang Jiang ◽  
...  
Keyword(s):  
T Cells ◽  
Liver Injury ◽  
Vascular Endothelium ◽  
Scavenger Receptor ◽  
Activated T Cells ◽  
Necrosis Factor Alpha ◽  
Lps Challenge ◽  
Cxc Chemokine ◽  
Chemokine Ligand ◽  
Oxidized Lipoprotein

ABSTRACT A murine model of endotoxin-induced lethal liver injury induced by Mycobacterium bovis BCG plus lipopolysaccharide (LPS) has been widely accepted and used. It has been reported that T cells play an important role in the pathogenesis of liver damage in this model. However, the precise mechanisms involved in regulation of the trafficking of effector T cells need to be elucidated. In the present study, we first reported that CXCL16/SR-PSOX (CXC chemokine ligand 16/scavenger receptor that binds phosphatidylserine and oxidized lipoprotein), a chemokine containing both membrane-anchored and soluble forms, was strongly up-regulated and predominantly distributed in the vascular endothelium in the injured liver tissue in the model. The secretory and membrane-anchored CXCL16/SR-PSOX functioned as a chemokine and an adhesive molecule, respectively, to attract T cells to a tumor necrosis factor alpha-activated endothelial cell line (SVEC) in vitro. To further identify the pathophysiological roles of CXCL16/SR-PSOX in the liver injury, the anti-CXCL16 antibody was administered to the BCG-primed mice before LPS challenge in vivo. Significant protection effects were observed with 70% of mice regarding lethality, the massive necrosis in the liver was reduced, and the intrahepatic infiltrating T cells were significantly inhibited. Taken together, these findings strongly suggest that functional CXCL16/SR-PSOX, as both a chemokine and an adhesion molecule, may be involved in the pathogenesis of the endotoxin-induced lethal liver injury via recruitment and adhesion of activated T cells to the vascular endothelium.

Mitomycin C-treated or irradiated concanavalin A-activated T cells augment the activation of cytotoxic T cells in vivo

1984 ◽  
Vol 88 (1) ◽  
pp. 123-128 ◽  
Author(s):  
Cornelia Moyers ◽  
Christiane Pottmeyer-Gerber ◽  
Martin Gerber ◽  
Heinz Buszello ◽  
Wulf Dröge
Keyword(s):  
T Cells ◽  
Mitomycin C ◽  
Concanavalin A ◽  
Cytotoxic T Cells ◽  
Activated T Cells

Deficiency of O-linked-glycosylation regulates activation of T cells and aggravates Concanavalin A-induced liver injury

Toxicology ◽  
2020 ◽  
Vol 433-434 ◽  
pp. 152411
Author(s):  
Xiaohua Hao ◽  
Meixin Gao ◽  
Lingling He ◽  
Xiaohui Ye ◽  
Junru Yang ◽  
...  
Keyword(s):  
T Cells ◽  
Liver Injury ◽  
Concanavalin A

IL-6, IFN-γ and TNF-α production by liver-associated T cells and acute liver injury in rats administered concanavalin A

1998 ◽  
Vol 76 (6) ◽  
pp. 542-549 ◽  
Author(s):  
Qi Cao ◽  
Robert Batey ◽  
Gerald Pang ◽  
Adrian Russell ◽  
Robert Clancy
Keyword(s):  
T Cells ◽  
Liver Injury ◽  
Concanavalin A ◽  
Acute Liver Injury ◽  
Tnf Α ◽  
Ifn Γ

scholarly journals In vitro studies of the rabbit immune system. V. Suppressor T cells activated by concanavalin A block the proliferation, not the induction of antierythrocyte plaque-forming cells.

1976 ◽  
Vol 143 (4) ◽  
pp. 919-936 ◽  
Author(s):  
D Redelman ◽  
C B Scott ◽  
H W Sheppard ◽  
S Sell
Keyword(s):  
T Cells ◽  
B Cells ◽  
Concanavalin A ◽  
Peripheral Blood ◽  
Suppressor Cells ◽  
Spleen Cells ◽  
Suppressor T Cells ◽  
Con A ◽  
Activated T Cells

The late B-cell proliferative phase of the in vitro antibody response by rabbit spleen cells is highly susceptible to suppression by activated T cells. The in vitro antisheep erythrocyte plaque-forming cell (PFC) response by spleen cells from normal or primed rabbits can be suppressed by adding concanavalin A (Con A), Con A-prestimulated peripheral blood or spleen lymphocytes, or supernates from Con A-prestimulated peripheral blood lymphocytes. The suppression is not mediated by a direct interaction of Con A with responding cells as shown by the effectiveness of prestimulated cells. Primed spleen cultures remain sensitive to Con A suppression as late as 72 h after initiation, and the addition of Con A after 24-72 h rapidly stops the increase in the number of PFC. T cells are required for Con A addition to be effective but the suppression can be induced at a time when T-helper cells are no longer necessary. Further, the suppressive effect of Con A addition is abrogated by specific antisera to rabbit T cells. We propose that Con A activates suppressor T cells which then exert their effects on proliferating PFC or their immediate precursor B cells. The early inductive or recruitment phase of the response is probably not blocked by suppressor cells. Also, there is an apparent relationship between the number of proliferating B cells and the number of suppressor cells required. Finally, the difficulties in inducing a stimulatory effect by Con A and the prolonged period that Con A addition is suppressive suggests that the rabbit has relatively more and/or longer-lived suppressor cells than the mouse and may be a particularly useful species for studying suppressive phenomena and their mechanisms.

Selective triggering of apoptosis of concanavalin A-activated T cells by fraxinellone for the treatment of T-cell-dependent hepatitis in mice

2009 ◽  
Vol 77 (11) ◽  
pp. 1717-1724 ◽  
Author(s):  
Yang Sun ◽  
Yu Qin ◽  
Fang-Yuan Gong ◽  
Xue-Feng Wu ◽  
Zi-Chun Hua ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Concanavalin A ◽  
Activated T Cells
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