scholarly journals IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice

Hepatology ◽  
2007 ◽  
Vol 45 (2) ◽  
pp. 475-485 ◽  
Author(s):  
Annette Erhardt ◽  
Markus Biburger ◽  
Thomas Papadopoulos ◽  
Gisa Tiegs
Keyword(s):  
T Cells ◽  
Liver Injury ◽  
Regulatory T Cells ◽  
Kupffer Cells ◽  
Concanavalin A

Dregea volubilisAmeliorates Concanavalin A-Induced Liver Injury by Facilitating Apoptosis of Activated T Cells

2008 ◽  
Vol 233 (9) ◽  
pp. 1124-1132 ◽  
Author(s):  
Fangyuan Gong ◽  
Yan Shen ◽  
Chaofeng Zhang ◽  
Jianliang Xu ◽  
Xuefeng Wu ◽  
...  
Keyword(s):  
T Cells ◽  
Liver Injury ◽  
Concanavalin A ◽  
Activated T Cells

scholarly journals CD4+CD25+ Regulatory T Cells Inhibit Natural Killer Cell Hepatocytotoxicity of Hepatitis B Virus Transgenic Mice via Membrane-Bound TGF-β and OX40

2015 ◽  
Vol 8 (1) ◽  
pp. 30-42 ◽  
Author(s):  
Yongyan Chen ◽  
Rui Sun ◽  
Xunyao Wu ◽  
Min Cheng ◽  
Haiming Wei ◽  
...  
Keyword(s):  
T Cells ◽  
Hepatitis B Virus ◽  
Liver Injury ◽  
Hepatitis B ◽  
Regulatory T Cells ◽  
Natural Killer ◽  
Nk Cell ◽  
Cell Contact ◽  
B Virus ◽  
Membrane Bound

CD4+CD25+ regulatory T cells (Tregs) are involved in the regulation of physiological and pathological hepatic immune responses, but the roles are not well explored in natural killer (NK) cell-mediated liver diseases. In this study, using the NK cell-mediated oversensitive liver injury model of hepatitis B virus transgenic (HBs-Tg) mice triggered by a low dose of concanavalin A, it was observed that an increased number of CD4+CD25+Foxp3+ Tregs were accumulated in the liver, along with the recovery of liver injury. Adoptive transfer of hepatic Tregs from HBs-Tg mice but not wild B6 mice could significantly attenuate the oversensitive liver injury via inhibiting liver accumulation and decreasing NK cell group 2D-mediated activation of NK cells in the recipient HBs-Tg mice. Furthermore, upregulated expression of membrane-bound TGF-β (mTGF-β) and OX40 on hepatic Tregs were demonstrated to account for inhibiting the NK cell-mediated hepatic injury in HBs-Tg mice through cell-cell contact, confirmed by antibody blockade and cell Transwell experiments in vivo and in vitro. Our findings for the first time indicated that CD4+CD25+ Tregs directly suppressed NK cell-mediated hepatocytotoxicity through mTGF-β and OX40/OX40L interaction in a cell-cell contact manner in HBV-associated liver disease.

scholarly journals Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver

Hepatology ◽  
2009 ◽  
Vol 50 (2) ◽  
pp. 612-621 ◽  
Author(s):  
Ekaterina Breous ◽  
Suryanarayan Somanathan ◽  
Luk H. Vandenberghe ◽  
James M. Wilson
Keyword(s):  
T Cells ◽  
T Cell ◽  
Regulatory T Cells ◽  
Kupffer Cells ◽  
T Cell Tolerance ◽  
Cell Tolerance ◽  
Murine Liver

Regulatory T cells ameliorate acetaminophen-induced immune-mediated liver injury

2015 ◽  
Vol 25 (2) ◽  
pp. 293-301 ◽  
Author(s):  
Xuefu Wang ◽  
Rui Sun ◽  
Yongyan Chen ◽  
Zhe-Xiong Lian ◽  
Haiming Wei ◽  
...  
Keyword(s):  
T Cells ◽  
Liver Injury ◽  
Regulatory T Cells ◽  
Immune Mediated
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