Regulatory Effects of Hydrogen Sulfide on IL-6, IL-8 and IL-10 Levels in the Plasma and Pulmonary Tissue of Rats with Acute Lung Injury

2008 ◽  
Vol 233 (9) ◽  
pp. 1081-1087 ◽  
Author(s):  
Tianshui Li ◽  
Bin Zhao ◽  
Cong Wang ◽  
Haiying Wang ◽  
Zhiwei Liu ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Pulmonary Tissue ◽  
Regulatory Effects

scholarly journals H2S in acute lung injury: a therapeutic dead end(?)

2020 ◽  
Vol 8 (S1) ◽  
Author(s):  
Tamara Merz ◽  
Nicole Denoix ◽  
Martin Wepler ◽  
Holger Gäßler ◽  
David A. C. Messerer ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Circulatory Shock ◽  
Therapeutic Window ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Clinical Reality ◽  
Dead End

AbstractThis review addresses the plausibility of hydrogen sulfide (H2S) therapy for acute lung injury (ALI) and circulatory shock, by contrasting the promising preclinical results to the present clinical reality. The review discusses how the narrow therapeutic window and width, and potentially toxic effects, the route, dosing, and timing of administration all have to be balanced out very carefully. The development of standardized methods to determine in vitro and in vivo H2S concentrations, and the pharmacokinetics and pharmacodynamics of H2S-releasing compounds is a necessity to facilitate the safety of H2S-based therapies. We suggest the potential of exploiting already clinically approved compounds, which are known or unknown H2S donors, as a surrogate strategy.

Hydrogen sulfide attenuates ferroptosis and stimulates autophagy by blocking mTOR signaling in sepsis-induced acute lung injury

2022 ◽  
Vol 141 ◽  
pp. 318-327
Author(s):  
Jianhua Li ◽  
Mengyu Li ◽  
Ling Li ◽  
Jiamin Ma ◽  
Chengye Yao ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Mtor Signaling

Treatment with exogenous hydrogen sulfide attenuates hyperoxia-induced acute lung injury in mice

2013 ◽  
Vol 113 (6) ◽  
pp. 1555-1563 ◽  
Author(s):  
Huai-Dong Li ◽  
Zhao-Rui Zhang ◽  
Qing-Xiang Zhang ◽  
Zhi-Chu Qin ◽  
Deng-Ming He ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Acute Lung Injury ◽  
Lung Injury

Punicalagin exhibits negative regulatory effects on LPS-induced acute lung injury

2014 ◽  
Vol 239 (5) ◽  
pp. 837-845 ◽  
Author(s):  
Shuang Guan ◽  
Zhenning Wang ◽  
Yixuan Huang ◽  
Guoren Huang ◽  
Yuekai Guan ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Regulatory Effects

Protective effect of hydrogen sulfide in a murine model of acute lung injury induced by combined burn and smoke inhalation

2008 ◽  
Vol 115 (3) ◽  
pp. 91-97 ◽  
Author(s):  
Aimalohi Esechie ◽  
Levente Kiss ◽  
Gabor Olah ◽  
Eszter M. Horváth ◽  
Hal Hawkins ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Murine Model ◽  
Smoke Inhalation ◽  
In Vivo Studies ◽  
Protective Effects ◽  
Pulmonary Endothelium ◽  
Anti Inflammatory

Acute lung injury results in a severe inflammatory response, which leads to priming and activation of leucocytes, release of reactive oxygen and reactive nitrogen species, destruction of pulmonary endothelium, extravasation of protein-rich fluid into the interstitium and formation of oedema. Recently, H2S (hydrogen sulfide) has been shown to decrease the synthesis of pro-inflammatory cytokines, reduce leucocyte adherence to the endothelium and subsequent diapedesis of these cells from the microvasculature in in vivo studies, and to protect cells in culture from oxidative injury. In the present study, we hypothesized that a parenteral formulation of H2S would reduce the lung injury induced by burn and smoke inhalation in a novel murine model. H2S post-treatment significantly decreased mortality and increased median survival in mice. H2S also inhibited IL (interleukin)-1β levels and significantly increased the concentration of the anti-inflammatory cytokine IL-10 in lung tissue. Additionally, H2S administration attenuated protein oxidation following injury and improved the histological condition of the lung. In conclusion, these results suggest that H2S exerts protective effects in acute lung injury, at least in part through the activation of anti-inflammatory and antioxidant pathways.

scholarly journals Hydrogen Sulfide Exerts Anti-oxidative and Anti-inflammatory Effects in Acute Lung Injury

Inflammation ◽  
2017 ◽  
Vol 41 (1) ◽  
pp. 249-259 ◽  
Author(s):  
Kornelia K. Zimmermann ◽  
Sashko G. Spassov ◽  
Karl M. Strosing ◽  
Paul M. Ihle ◽  
Helen Engelstaedter ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Anti Inflammatory
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