Interleukin-10-Overexpressing Mesenchymal Stromal Cells Induce a Series of Regulatory Effects in the Inflammatory System and Promote the Survival of Endotoxin-Induced Acute Lung Injury in Mice Model

2018 ◽  
Vol 37 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Chenfei Wang ◽  
Dan Lv ◽  
Xiaobin Zhang ◽  
Zhu-ang Ni ◽  
Xiaofan Sun ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Interleukin 10 ◽  
Mice Model ◽  
Regulatory Effects ◽  
Inflammatory System

scholarly journals Human mesenchymal stromal cells decrease the severity of acute lung injury induced by E. coli in the rat

Thorax ◽  
2015 ◽  
Vol 70 (7) ◽  
pp. 625-635 ◽  
Author(s):  
J. Devaney ◽  
S. Horie ◽  
C. Masterson ◽  
S. Elliman ◽  
F. Barry ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
E Coli ◽  
Human Mesenchymal Stromal Cells

scholarly journals Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo

2016 ◽  
Vol 113 (13) ◽  
pp. 3621-3626 ◽  
Author(s):  
Michael C. W. Chan ◽  
Denise I. T. Kuok ◽  
Connie Y. H. Leung ◽  
Kenrie P. Y. Hui ◽  
Sophie A. Valkenburg ◽  
...  
Keyword(s):  
Hong Kong ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Influenza A ◽  
Alveolar Fluid Clearance ◽  
Protein Permeability

Influenza can cause acute lung injury. Because immune responses often play a role, antivirals may not ensure a successful outcome. To identify pathogenic mechanisms and potential adjunctive therapeutic options, we compared the extent to which avian influenza A/H5N1 virus and seasonal influenza A/H1N1 virus impair alveolar fluid clearance and protein permeability in an in vitro model of acute lung injury, defined the role of virus-induced soluble mediators in these injury effects, and demonstrated that the effects are prevented or reduced by bone marrow-derived multipotent mesenchymal stromal cells. We verified the in vivo relevance of these findings in mice experimentally infected with influenza A/H5N1. We found that, in vitro, the alveolar epithelium’s protein permeability and fluid clearance were dysregulated by soluble immune mediators released upon infection with avian (A/Hong Kong/483/97, H5N1) but not seasonal (A/Hong Kong/54/98, H1N1) influenza virus. The reduced alveolar fluid transport associated with down-regulation of sodium and chloride transporters was prevented or reduced by coculture with mesenchymal stromal cells. In vivo, treatment of aged H5N1-infected mice with mesenchymal stromal cells increased their likelihood of survival. We conclude that mesenchymal stromal cells significantly reduce the impairment of alveolar fluid clearance induced by A/H5N1 infection in vitro and prevent or reduce A/H5N1-associated acute lung injury in vivo. This potential adjunctive therapy for severe influenza-induced lung disease warrants rapid clinical investigation.

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