scholarly journals Intake of Diet Including 1% Ovomucoid for 4 Weeks Induces Oral Desensitization in Ovomucoid-Specific Allergic Mouse Model

2017 ◽  
Vol 63 (2) ◽  
pp. 104-110 ◽  
Author(s):  
Akihiro MAETA ◽  
Yoko SAKAMOTO ◽  
Sayo YUKI ◽  
Kyoko TAKAHASHI
Keyword(s):  
Mouse Model ◽  
Allergic Mouse ◽  
Oral Desensitization

Diets Supplemented with 1% Egg White Induce Oral Desensitization and Immune Tolerance in an Egg White-Specific Allergic Mouse Model

2018 ◽  
Vol 176 (3-4) ◽  
pp. 205-214 ◽  
Author(s):  
Akihiro Maeta ◽  
Marin Matsushima ◽  
Risako Katahira ◽  
Natsumi Sakamoto ◽  
Kyoko Takahashi
Keyword(s):  
Mouse Model ◽  
Immune Tolerance ◽  
Egg White ◽  
Allergic Mouse ◽  
Oral Desensitization

Genetic Ablation of the src Kinase p59fynT Exacerbates Pulmonary Inflammation in an Allergic Mouse Model

2001 ◽  
Vol 24 (4) ◽  
pp. 469-474 ◽  
Author(s):  
Elizabeth M. Kudlacz ◽  
Catharine J. Andresen ◽  
Michelle Salafia ◽  
Carrie A. Whitney ◽  
Barbara Naclerio ◽  
...  
Keyword(s):  
Mouse Model ◽  
Pulmonary Inflammation ◽  
Src Kinase ◽  
Genetic Ablation ◽  
Allergic Mouse

Blocking ATP releasing channels prevents high extracellular ATP levels and airway hyperreactivity in an asthmatic mouse model

2021 ◽  
Author(s):  
Llilian Arzola Martínez ◽  
Rebeca Benavente ◽  
Génesis Vega ◽  
Mariana Ríos ◽  
Wendy Fonseca ◽  
...  
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Airway Epithelium ◽  
Atp Release ◽  
Specific Inhibitor ◽  
Extracellular Atp ◽  
Airway Hyperreactivity ◽  
Luciferase Assay ◽  
Asthmatic Patients ◽  
Allergic Mouse

Allergic asthma is a chronic airway inflammatory response to different triggers like inhaled allergens. Excessive ATP in fluids from asthmatic patients is considered an inflammatory signal and an important autocrine/paracrine modulator of airway physiology. Here we investigated the deleterious effect of increased extracellular ATP (eATP) concentration on the mucociliary clearance (MCC) effectiveness and determined the role of ATP releasing channels during airway inflammation in an ovalbumin (OVA)-sensitized mouse model. Our allergic mouse model exhibited high levels of eATP measured in the tracheal fluid with a luciferin-luciferase assay and reduced MCC velocity determined by microspheres tracking in the trachea ex vivo. Addition of ATP had a dual effect on MCC, where lower ATP concentration (µM) increased microspheres velocity, while higher concentration (mM) transiently stopped microspheres movement. Also, an augmented ethidium bromide uptake by the allergic tracheal airway epithelium suggests an increase in ATP release channel functionality during inflammatory conditions. The use of carbenoxolone, a non-specific inhibitor of connexin and pannexin1channels reduced the eATP concentration in the allergic mouse tracheal fluid and dye uptake by the airway epithelium, providing evidence that these ATP release channels are facilitating the net flux of ATP to the lumen during airway inflammation. However, only the specific inhibition of pannexin1 with 10Panx peptide significantly reduced eATP in bronchoalveolar lavage and decreased airway hyperresponsiveness in OVA-allergic mouse model. These data provide evidence that blocking eATP may be a pharmacological alternative to be explored in rescue therapy during episodes of airflow restriction in asthmatic patients.

Characterization of adenosine receptor(s) involved in adenosine-induced bronchoconstriction in an allergic mouse model

2003 ◽  
Vol 284 (6) ◽  
pp. L1012-L1019 ◽  
Author(s):  
Ming Fan ◽  
Weixi Qin ◽  
S. Jamal Mustafa
Keyword(s):  
Mouse Model ◽  
Adenosine Receptor ◽  
Receptor Subtypes ◽  
Dependent Manner ◽  
Transcript Levels ◽  
Allergen Sensitization ◽  
Selective Agonist ◽  
Dose Dependent ◽  
Allergic Mouse

We recently reported that adenosine caused bronchoconstriction and enhanced airway inflammation in an allergic mouse model. In this study, we further report the characterization of the subtype of adenosine receptor(s) involved in bronchoconstriction. 5′-( N-ethylcarboxamido)adenosine (NECA), a nonselective adenosine agonist, elicited bronchoconstriction in a dose-dependent manner. Little effects of N 6-cyclopentyladenosine (A1-selective agonist) and 2- p-(2-carboxyethyl)phenethylamino-5′- N-ethylcarboxamidoadenosine (A2A-selective agonist) compared with NECA were observed in this model. 2-Chloro- N 6-(3-iodobenzyl)-9-[5-(methylcarbamoyl)-β-d-ribofuranosyl]adenosine, an A3-selective receptor agonist, produced a dose-dependent bronchoconstrictor response, which was blocked by selective A3 antagonist 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate (MRS1523). However, MRS1523 only partially inhibited NECA-induced bronchoconstriction. Neither selective A1 nor A2A antagonists affected NECA-induced bronchoconstriction. Enprofylline, a relatively selective A2B receptor antagonist, blocked partly NECA-induced bronchoconstriction. Furthermore, a combination of enprofylline and MRS1523 completely abolished NECA-induced bronchoconstrictor response. Using RT-PCR, we found that all four adenosine receptor subtypes are expressed in control lungs. Allergen sensitization and challenge significantly increased transcript levels of the A2B and A3receptors, whereas the A1 receptor message decreased. No change in transcript levels of A2A receptors was observed after allergen sensitization and challenge. These findings suggest that A2B and A3 adenosine receptors play an important role in adenosine-induced bronchoconstriction in our allergic mouse model. Finally, whether the airway effects of the receptor agonists/antagonists are direct or indirect needs further investigations.

scholarly journals Absence of Angiotensin ll type 2 (AT 2 ) Receptors Increases Airway Inflammation and Responsiveness in an Allergic Mouse Model of Asthma

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Riyakumar Bhavsar ◽  
Sahith Rajalingam ◽  
Mehaben Patel ◽  
Praveena Prasad ◽  
Dovenia S Ponnoth
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Allergic Mouse

Differential Effects of Particulate Matter Upwind and Downwind of an Urban Freeway in an Allergic Mouse Model

2015 ◽  
Vol 49 (6) ◽  
pp. 3930-3939 ◽  
Author(s):  
Marie A. McGee ◽  
Ali S. Kamal ◽  
John K. McGee ◽  
Charles E. Wood ◽  
Janice A. Dye ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Mouse Model ◽  
Differential Effects ◽  
Urban Freeway ◽  
Allergic Mouse

scholarly journals Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Kana Tanabe ◽  
Eri Kitagawa ◽  
Misaki Wada ◽  
Atsushi Haraguchi ◽  
Kanami Orihara ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mouse Model ◽  
Light Period ◽  
Allergic Mouse
Sign in / Sign up

Export Citation Format

Share Document