scholarly journals Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Kana Tanabe ◽  
Eri Kitagawa ◽  
Misaki Wada ◽  
Atsushi Haraguchi ◽  
Kanami Orihara ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mouse Model ◽  
Light Period ◽  
Allergic Mouse

Anti-allergenic effects of peanut sprouts extract in a systemic anaphylaxis food allergy mouse model

2019 ◽  
Author(s):  
WK Yang ◽  
DS Kim ◽  
E Son ◽  
YM Lee ◽  
DS Lee ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mouse Model ◽  
Systemic Anaphylaxis

Therapeutic Effect of Kakkonto in a Mouse Model of Food Allergy with Gastrointestinal Symptoms

2009 ◽  
Vol 148 (3) ◽  
pp. 175-185 ◽  
Author(s):  
Takeshi Yamamoto ◽  
Kanae Fujiwara ◽  
Minako Yoshida ◽  
Natsuko Kageyama-Yahara ◽  
Hirofumi Kuramoto ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mouse Model ◽  
Therapeutic Effect ◽  
Gastrointestinal Symptoms

scholarly journals Gastric Enzyme Supplementation Inhibits Food Allergy in a BALB/c Mouse Model

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 738
Author(s):  
Nazanin Samadi ◽  
Denise Heiden ◽  
Martina Klems ◽  
Martina Salzmann ◽  
Johanna Rohrhofer ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mouse Model ◽  
Gastric Acid ◽  
Clinical Symptoms ◽  
Acid Suppression ◽  
Gastric Digestion ◽  
Enzyme Solution ◽  
Allergic Symptoms ◽  
Gastric Acid Suppression ◽  
The Impact

Impaired gastric digestion due to suppressed gastric acidity enhances the risk for food allergy development. In the current study, we aimed to evaluate the impact of a supported gastric digestion via application of a pharmaceutical gastric enzyme solution (GES) on food allergy development and allergic reactions in a BALB/c mouse model. The ability of the GES to restore hypoacidic conditions was tested in mice treated with gastric acid suppression medication. To evaluate the impact on allergic symptoms, mice were orally sensitized with ovalbumin (OVA) under gastric acid suppression and subjected to oral challenges with or without GES. The immune response was evaluated by measurement of antibody titers, cytokine levels, mucosal allergy effector cell influx and regulatory T-cell counts. Clinical response was objectified by core body temperature measurements after oral OVA challenge. Supplementation of GES transiently restored physiological pH levels in the stomach after pharmaceutical gastric acid suppression. During oral sensitization, supplementation of gastric enzymes significantly reduced systemic IgE, IgG1 and IgG2a levels and allergic symptoms. In food allergic mice, clinical symptoms were reduced by co-administration of the gastric enzyme solution. Support of gastric digestion efficiently prevents food allergy induction and alleviates clinical symptoms in our food allergy model.

Genetic Ablation of the src Kinase p59fynT Exacerbates Pulmonary Inflammation in an Allergic Mouse Model

2001 ◽  
Vol 24 (4) ◽  
pp. 469-474 ◽  
Author(s):  
Elizabeth M. Kudlacz ◽  
Catharine J. Andresen ◽  
Michelle Salafia ◽  
Carrie A. Whitney ◽  
Barbara Naclerio ◽  
...  
Keyword(s):  
Mouse Model ◽  
Pulmonary Inflammation ◽  
Src Kinase ◽  
Genetic Ablation ◽  
Allergic Mouse

Study on alleviation effect of stachyose on food allergy through TLR2/NF-κB signal pathway in a mouse model

Life Sciences ◽  
2021 ◽  
pp. 120038
Author(s):  
Qian Li ◽  
Xinlei Tang ◽  
Jianghao Xu ◽  
Xingyuan Ren ◽  
Rui Wang ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mouse Model ◽  
Signal Pathway

scholarly journals Structural changes induced by heating affect ovalbumin-antigen processing and reduce allergic response in mouse model of food allergy

2014 ◽  
Vol 4 (S2) ◽  
Author(s):  
Jaroslav Goliáš ◽  
Martin Schwarzer ◽  
Hana Kozáková ◽  
Dagmar Šrùtková ◽  
Ludmila Tuèková
Keyword(s):  
Food Allergy ◽  
Mouse Model ◽  
Antigen Processing ◽  
Structural Changes ◽  
Allergic Response

Blocking ATP releasing channels prevents high extracellular ATP levels and airway hyperreactivity in an asthmatic mouse model

2021 ◽  
Author(s):  
Llilian Arzola Martínez ◽  
Rebeca Benavente ◽  
Génesis Vega ◽  
Mariana Ríos ◽  
Wendy Fonseca ◽  
...  
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Airway Epithelium ◽  
Atp Release ◽  
Specific Inhibitor ◽  
Extracellular Atp ◽  
Airway Hyperreactivity ◽  
Luciferase Assay ◽  
Asthmatic Patients ◽  
Allergic Mouse

Allergic asthma is a chronic airway inflammatory response to different triggers like inhaled allergens. Excessive ATP in fluids from asthmatic patients is considered an inflammatory signal and an important autocrine/paracrine modulator of airway physiology. Here we investigated the deleterious effect of increased extracellular ATP (eATP) concentration on the mucociliary clearance (MCC) effectiveness and determined the role of ATP releasing channels during airway inflammation in an ovalbumin (OVA)-sensitized mouse model. Our allergic mouse model exhibited high levels of eATP measured in the tracheal fluid with a luciferin-luciferase assay and reduced MCC velocity determined by microspheres tracking in the trachea ex vivo. Addition of ATP had a dual effect on MCC, where lower ATP concentration (µM) increased microspheres velocity, while higher concentration (mM) transiently stopped microspheres movement. Also, an augmented ethidium bromide uptake by the allergic tracheal airway epithelium suggests an increase in ATP release channel functionality during inflammatory conditions. The use of carbenoxolone, a non-specific inhibitor of connexin and pannexin1channels reduced the eATP concentration in the allergic mouse tracheal fluid and dye uptake by the airway epithelium, providing evidence that these ATP release channels are facilitating the net flux of ATP to the lumen during airway inflammation. However, only the specific inhibition of pannexin1 with 10Panx peptide significantly reduced eATP in bronchoalveolar lavage and decreased airway hyperresponsiveness in OVA-allergic mouse model. These data provide evidence that blocking eATP may be a pharmacological alternative to be explored in rescue therapy during episodes of airflow restriction in asthmatic patients.

Turmeric (Curcuma longa) attenuates food allergy symptoms by regulating type 1/type 2 helper T cells (Th1/Th2) balance in a mouse model of food allergy

2015 ◽  
Vol 175 ◽  
pp. 21-29 ◽  
Author(s):  
Hee Soon Shin ◽  
Hye-Jeong See ◽  
Sun Young Jung ◽  
Dae Woon Choi ◽  
Da-Ae Kwon ◽  
...  
Keyword(s):  
T Cells ◽  
Food Allergy ◽  
Mouse Model ◽  
Curcuma Longa ◽  
Helper T Cells

Antigen-specific T cell–mediated apoptosis of dendritic cells is impaired in a mouse model of food allergy☆

2004 ◽  
Vol 113 (5) ◽  
pp. 965-972 ◽  
Author(s):  
Angela L. Man ◽  
Eugenio Bertelli ◽  
Mari Regoli ◽  
Stephen J. Chambers ◽  
Claudio Nicoletti
Keyword(s):  
Dendritic Cells ◽  
Food Allergy ◽  
T Cell ◽  
Mouse Model
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