scholarly journals Protective Effects of Grape Seed Proanthocyanidin Extracts on Cerebral Cortex of Streptozotocin-Induced Diabetic Rats through Modulating AGEs/RAGE/NF-κB Pathway

2010 ◽  
Vol 56 (2) ◽  
pp. 87-97 ◽  
Author(s):  
Mei LU ◽  
Ling XU ◽  
Baoying LI ◽  
Weidong ZHANG ◽  
Chengmei ZHANG ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Grape Seed ◽  
Diabetic Rats ◽  
Protective Effects ◽  
Grape Seed Proanthocyanidin

scholarly journals Grape Seed Proanthocyanidin Extract Prevents Ovarian Aging by Inhibiting Oxidative Stress in the Hens

2018 ◽  
Vol 2018 ◽  
pp. 1-16 ◽  
Author(s):  
Xingting Liu ◽  
Xin Lin ◽  
Yuling Mi ◽  
Jian Li ◽  
Caiqiao Zhang
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Capacity ◽  
Chromatin Condensation ◽  
Natural Aging ◽  
Grape Seed ◽  
Protective Effects ◽  
Ovarian Aging ◽  
Grape Seed Proanthocyanidin Extract ◽  
Age Related ◽  
Grape Seed Proanthocyanidin

Oxidative stress is an important inducement in ovarian aging which results in fecundity decline in human and diverse animals. As a potent antioxidant, grape seed proanthocyanidin extract (GSPE) was investigated to ameliorate chicken ovarian aging in this study. Firstly, ovarian antioxidant capacity of hens at different ages (90, 150, 280, and 580 days old) was compared to elucidate its age-related changes. Subsequently, a D-gal-induced (2.5 mg/mL) aging ovarian model was established and the cultured ovarian tissues were treated with GSPE at 5 μg/mL for 72 h to evaluate the putative attenuating effects of GSPE on ovarian aging. Meanwhile, ovaries of D280 (young) and D580 (old) were treated with GSPE for 72 h in culture to verify the protective effects of GSPE on natural aging ovary. The results showed that GSPE could rescue the antioxidant capacity decline by increasing the antioxidase activities and their gene expression in either D-gal-induced or natural aging ovaries. Moreover, GSPE could maintain the homeostasis between cell proliferation and apoptosis in the D-gal-induced and natural aging ovaries, as well as alleviate D-gal-induced nucleus chromatin condensation in the ovarian granulosa cells. In conclusion, GSPE treatment can effectively prevent the ovarian aging process in hens by reducing oxidative stress.

scholarly journals Effects of Grape Seed Proanthocyanidin Extracts on Peripheral Nerves in Streptozocin-Induced Diabetic Rats

2008 ◽  
Vol 54 (4) ◽  
pp. 321-328 ◽  
Author(s):  
Xiao-pei CUI ◽  
Bao-ying LI ◽  
Hai-qing GAO ◽  
Na WEI ◽  
Wei-ling WANG ◽  
...  
Keyword(s):  
Peripheral Nerves ◽  
Grape Seed ◽  
Diabetic Rats ◽  
Grape Seed Proanthocyanidin

scholarly journals Effects of grape seed proanthocyanidin extract on renal injury in type 2 diabetic rats

2014 ◽  
Vol 11 (1) ◽  
pp. 645-652 ◽  
Author(s):  
LEI BAO ◽  
ZHAOFENG ZHANG ◽  
XIAOQIAN DAI ◽  
YE DING ◽  
YANFEI JIANG ◽  
...  
Keyword(s):  
Renal Injury ◽  
Grape Seed ◽  
Diabetic Rats ◽  
Grape Seed Proanthocyanidin Extract ◽  
Grape Seed Proanthocyanidin ◽  
Type 2 Diabetic

Cardioprotective roles of aged garlic extract, grape seed proanthocyanidin, and hazelnut on doxorubicin-induced cardiotoxicity

2009 ◽  
Vol 87 (8) ◽  
pp. 633-640 ◽  
Author(s):  
Erkan Demirkaya ◽  
Aslıhan Avci ◽  
Vural Kesik ◽  
Yıldırım Karslioglu ◽  
Emin Oztas ◽  
...  
Keyword(s):  
Grape Seed ◽  
Garlic Extract ◽  
Natural Antioxidant ◽  
Male Rats ◽  
Free Oxygen Radicals ◽  
Protective Effects ◽  
Aged Garlic Extract ◽  
Positive Effects ◽  
Grape Seed Proanthocyanidin ◽  
Aged Garlic

Doxorubicin (DXR) is a chemotherapeutic agent used effectively in the treatment of several childhood malignancies. During treatment, cardiotoxicity caused by cell damage due to the free oxygen radicals that are generated is a major limiting factor. This study was undertaken to determine whether DXR-induced cardiotoxicity could be prevented by natural foods with antioxidant properties such as aged garlic extract (AGEX), grape seed proanthocyanidin (PA), and hazelnut. Wistar albino male rats were assigned randomly to 9 groups each consisting of 15 rats. AGEX, PA, and hazelnut groups received these antioxidants in addition to their standard rat diet. They were also treated with cumulative intraperitoneal (i.p.) injections according to 2 different regimens: either a high-dose of 15 mg/kg DXR (3.75 mg/kg per week for 4 weeks) or a low-dose of 7.5 mg/kg DXR (1.875 mg/kg per week for 4 weeks). The control group received i.p. 0.9% saline. AGEX, PA, or hazelnut supplements were given orally to the groups for a 6-week period starting 1 week before the DXR treatment and ending 1 week after the treatment. One week after the last DXR injection, heart tissue samples were analyzed to determine malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and xanthine oxidase (XO) levels, and serum samples were taken for creatine kinase (CK). There were no significant changes in MDA levels among the control, DXR-treated groups, or supplemented groups that received additional natural antioxidant foods. SOD enzyme levels were decreased in rats treated with DXR. PA prevented the decrease at low doses of DXR. DXR treatment decreased CAT enzyme levels, but additional PA and hazelnut consumption increased these levels at low cumulative doses. XO enzyme levels were decreased in AGEX and hazelnut groups, but PA prevented the decrease. CK levels were elevated after DXR administration, indicating myocardial injury, but PA significantly reversed this. Although there were no differences histopathologically between AGEX, PA, and hazelnut groups, the protective effects of AGEX and PA were evident in electron microscopy. In conclusion, the positive effects of natural antioxidant foods on the prevention of DXR-induced cardiac injury could not be clearly shown on the basis of antioxidant enzymes. However, the electron microscopic changes clearly demonstrated the protective effects of AGEX and PA. The supplementation of these antioxidant foods over longer periods may show more definitive results. Human studies with different doses are needed to evaluate the effects of these foods on the human heart.

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