Oral Administration of Grape Seed Proanthocyanidin Extracts Downregulate RAGE Dependant Nuclear Factor- Kappa BP65 Expression in the Hippocampus of Streptozotocin Induced Diabetic Rats

2008 ◽  
Vol 116 (04) ◽  
pp. 215-224 ◽  
Author(s):  
L. Xu ◽  
B. Li ◽  
M. Cheng ◽  
W. Zhang ◽  
J. Pan ◽  
...  
Keyword(s):  
Oral Administration ◽  
Grape Seed ◽  
Diabetic Rats ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Grape Seed Proanthocyanidin

Lycopsamine Attenuates Diabetes Mellitus via The Nuclear Factor Kappa B-Induced 5′ Adenosine Monophosphate-Activated Protein Kinase Signal Pathway

2021 ◽  
Vol 20 (1) ◽  
pp. 169-176
Author(s):  
Jingfang Hu ◽  
Jie Jin ◽  
Yan Chen ◽  
Jinyi Wei ◽  
Hanbei Chen
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Protein Kinase ◽  
Nuclear Factor Kappa B ◽  
Adenosine Monophosphate ◽  
Interleukin 10 ◽  
Diabetic Rats ◽  
Nuclear Factor ◽  
Nonesterified Fatty Acids ◽  
Nuclear Factor Kappa

Diabetes mellitus is a metabolic disorder characterized by inflammation, abnormal glycolipid metabolism, insulin resistance, and mitochondrial dysfunction leading to hyperglycemia. The aim of the present investigation was to determine the efficacy of lycopsamine in a rat model of diabetes mellitus to understand its mechanism. Lycopsamine treatment markedly lowered the level of total cholesterol, triglyceride, nonesterified fatty acids, and low-density lipoprotein in diabetic rats. There was also a reduction in interleukin-6, interleukin-10, C-reactive protein, and tumor necrosis factor-α levels. Lycopsamine treatment normalized the metabolism of lipid and glucose, insulin resistance, and body weight of diabetic rats. Findings of immunohistochemical analyses exhibited rise in precipitation of immunocytes in renal cells. Results potentially demonstrated that lycopsamine treatment remarkably reduced the nuclear factor-kappa B level and enhanced the 5′ adenosine monophosphate-activated protein kinase expression. Altogether, administration of lycopsamine suppressed the expression of inflammatory cytokines and attenuated the metabolic symptoms in diabetes mellitus experimental rats.

scholarly journals Effects of Grape Seed Proanthocyanidin Extracts on Peripheral Nerves in Streptozocin-Induced Diabetic Rats

2008 ◽  
Vol 54 (4) ◽  
pp. 321-328 ◽  
Author(s):  
Xiao-pei CUI ◽  
Bao-ying LI ◽  
Hai-qing GAO ◽  
Na WEI ◽  
Wei-ling WANG ◽  
...  
Keyword(s):  
Peripheral Nerves ◽  
Grape Seed ◽  
Diabetic Rats ◽  
Grape Seed Proanthocyanidin

scholarly journals Effects of grape seed proanthocyanidin extract on renal injury in type 2 diabetic rats

2014 ◽  
Vol 11 (1) ◽  
pp. 645-652 ◽  
Author(s):  
LEI BAO ◽  
ZHAOFENG ZHANG ◽  
XIAOQIAN DAI ◽  
YE DING ◽  
YANFEI JIANG ◽  
...  
Keyword(s):  
Renal Injury ◽  
Grape Seed ◽  
Diabetic Rats ◽  
Grape Seed Proanthocyanidin Extract ◽  
Grape Seed Proanthocyanidin ◽  
Type 2 Diabetic

scholarly journals Grape Seed Proanthocyanidin Extract Prevents Bone Loss via Regulation of Osteoclast Differentiation, Apoptosis, and Proliferation

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3164
Author(s):  
Sung Chul Kwak ◽  
Yoon-Hee Cheon ◽  
Chang Hoon Lee ◽  
Hong Young Jun ◽  
Kwon-Ha Yoon ◽  
...  
Keyword(s):  
Bone Loss ◽  
Osteoclast Differentiation ◽  
Grape Seed ◽  
Mitogen Activated Protein Kinase ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Nuclear Factor ◽  
Systemic Injection ◽  
Grape Seed Proanthocyanidin Extract ◽  
Grape Seed Proanthocyanidin

Dietary procyanidin has been shown to be an important bioactive component that regulates various pharmacological activities to maintain metabolic homeostasis. In particular, grape seed proanthocyanidin extract (GSPE) is a commercially available medicine for the treatment of venous and lymphatic dysfunction. This study aimed to investigate whether GSPE protects against lipopolysaccharide (LPS)-induced bone loss in vivo and the related mechanism of action in vitro. The administration of GSPE restored the inflammatory bone loss phenotype stimulated by acute systemic injection of LPS in vivo. GSPE strongly suppressed receptor activator of nuclear factor kappa-B ligand (RANKL)-induced osteoclast differentiation and bone resorption activity of mature osteoclasts by decreasing the RANKL-induced nuclear factor-κB transcription activity. GSPE mediates this effect through decreased phosphorylation and degradation of NF-κB inhibitor (IκB) by IκB kinaseβ, subsequently inhibiting proto-oncogene cellular Fos and nuclear factor of activated T cells. Additionally, GSPE promotes osteoclast proliferation by increasing the phosphorylation of components of the Akt and mitogen-activated protein kinase signaling pathways and it also inhibits apoptosis by decreasing the activity of caspase-8, caspase-9, and caspase-3, as corroborated by a decrease in the Terminal deoxynucleotidyl transferase dUTP nick end labeling -positive cells. Our study suggests a direct effect of GSPE on the proliferation, differentiation, and apoptosis of osteoclasts and reveals the mechanism responsible for the therapeutic potential of GSPE in osteoclast-associated bone metabolism disease.

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